Structural characterization of the membrane mimetic interactions of the FATC domains of the protein kinase 'target of rapamycin' and related kinases

Autor: Sommer, Lisa A. M.

The phosphatidylinositol-3 kinase-related kinases (PIKKs) regulate metabolism and stress responses. The FATC domain has been shown to regulate their function. The immersion depth and orientation of the 'target of rapamycin' FATC domain in membranes a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______518::bbed8d6d0967aa4bb1dcee4a283d2105
https://mediatum.ub.tum.de/doc/1172466/document.pdf

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¹ H, ¹⁵ N, and ¹³ C chemical shift assignments of the micelle immersed FAT C-terminal (FATC) domains of the human protein kinases ataxia-telangiectasia mutated (ATM) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) fused to the B1 domain of streptococcal protein G (GB1).

Autor: Rahim MSA; Department of Chemistry, Biomolecular NMR Spectroscopy, Technische Universität München, Lichtenbergstr. 4, 85747, Garching, Germany., Sommer LAM; Department of Chemistry, Biomolecular NMR Spectroscopy, Technische Universität München, Lichtenbergstr. 4, 85747, Garching, Germany.; Roche Diagnostics GmbH, Centralised and Point of Care Solutions, Nonnenwald 2, 82377, Penzberg, Germany., Wacker A; Department of Chemistry, Biomolecular NMR Spectroscopy, Technische Universität München, Lichtenbergstr. 4, 85747, Garching, Germany.; Division of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Schaad M; Quintiles AG, Hochstrasse 50, 4053, Basel, Switzerland., Dames SA; Department of Chemistry, Biomolecular NMR Spectroscopy, Technische Universität München, Lichtenbergstr. 4, 85747, Garching, Germany. sonja.dames@tum.de.; Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany. sonja.dames@tum.de.

Publikováno v: Biomolecular NMR assignments [Biomol NMR Assign] 2018 Apr; Vol. 12 (1), pp. 149-154. Date of Electronic Publication: 2018 Jan 18.