Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Somenath Roy Chowdhury"'
Autor:
Somenath Roy Chowdhury, Subhendu K. Das, Bijoylaxmi Banerjee, Srijita Paul Chowdhuri, Hemanta K. Majumder, Benu Brata Das
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 36(4)
Leishmania donovani, a unicellular protozoan parasite, causes a wide range of human diseases including fatal visceral leishmaniasis. Tyrosyl DNA-phosphodiesterase 1 (TDP1) hydrolyzes the phosphodiester bond between DNA 3'-end and a tyrosyl moiety of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e36bfccfd10a24d3acebf04a95a7d5
https://pubmed.ncbi.nlm.nih.gov/35319800
https://pubmed.ncbi.nlm.nih.gov/35319800
Publikováno v:
Acta Tropica. 234:106613
Diseases caused by trypanosomatid parasites have no commercially available vaccines for human application. Treatment modalities completely rely on chemotherapeutics strategies that often exhibit clinical drawbacks, like host toxicity, side effects an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5ab3149a0923ef5b9a9d6975e6e338
https://doi.org/10.1016/j.actatropica.2022.106613
https://doi.org/10.1016/j.actatropica.2022.106613
Autor:
Elangovan Vellaichamy, Hemanta K. Majumder, Jayachandran Karunakaran, Saleem Iqbal, Nachiappan Dhatchana Moorthy, Arasambattu K. Mohanakrishnan, Somenath Roy Chowdhury, Krishnasamy Gunasekaran
Publikováno v:
ChemMedChem. 14:1418-1430
A new series of 3,4-ethylenedioxythiophene (EDOT)-appended propenones were prepared by condensation reaction and their in vitro cytotoxicity effects were evaluated against five human cancer cell lines. Preliminary structure-activity relationships of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54e2e4b2d15a0e4b04fe29fde6b8bd2
https://doi.org/10.1002/cmdc.201900225
https://doi.org/10.1002/cmdc.201900225
Publikováno v:
Trends in Biochemical Sciences. 44:415-432
All organisms, including unicellular pathogens, compulsorily possess DNA topoisomerases for successful nucleic acid metabolism. But particular subtypes of topoisomerases exist, in all prokaryotes and in some unicellular eukaryotes, that are absent in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32568c026cea274eeba36e6f21059ca
https://doi.org/10.1016/j.tibs.2018.12.001
https://doi.org/10.1016/j.tibs.2018.12.001
Publikováno v:
Current Issues in Molecular Biology
Volume 31
Issue 1
Pages 45-62
Volume 31
Issue 1
Pages 45-62
Topoisomerases are a group of enzymes that resolve DNA topological problems and aid in different DNA transaction processes viz. replication, transcription, recombination, etc. inside cells. These proteins accomplish their feats by steps of DNA strand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8621e1f747c8c9f94fd9ce248a473fa4
https://doi.org/10.21775/cimb.031.045
https://doi.org/10.21775/cimb.031.045
Infections caused by parasitic protozoa pose significant health problems in vertebrates including humans. Unlike bacterial and viral pathogens, the clinical combat against protozoan pathogens is primarily aided by chemotherapeutics because of the una
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fec7facc0eaf09fd9ac6b9b19cbdde1
https://doi.org/10.1016/b978-0-12-819483-6.00011-4
https://doi.org/10.1016/b978-0-12-819483-6.00011-4
Autor:
Hemanta K. Majumder, Nachiappan Dhatchana Moorthy, Thiyagarajan Mageshwaran, Ramamoorthy Siva, Somenath Roy Chowdhury, Karthikeyan Ganesan, Bose Muthu Ramalingam, Krishnasamy Gunasekaran, Saleem Iqbal, Sourav Saha, B. Navin Rajesh, Elangovan Vellaichamy, Arasambattu K. Mohanakrishnan
Publikováno v:
Journal of Medicinal Chemistry. 61:1285-1315
A series of calothrixin B (2) analogues bearing substituents at the ‘E’ ring and their corresponding deoxygenated quinocarbazoles lacking quinone unit were synthesized. The cytotoxicities of calothrixins 1, 2, and 15b–p and quinocarbazole analo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3474468146bf65dd0124afe32d42426
https://doi.org/10.1021/acs.jmedchem.7b01797
https://doi.org/10.1021/acs.jmedchem.7b01797
Autor:
Hemanta K. Majumder, Aline Araujo Zuma, Sara Teixeira de Macedo Silva, Neha Kumari, Sibabrata Mukhopadhyay, Ashok Kumar, Jean-Claude Dujardin, Juliany Cola Fernandes Rodrigues, Joseane Lima Prado Godinho, Syamal Roy, Somenath Roy Chowdhury, Shyam Sundar, Wanderley de Souza, Sourav Saha
Publikováno v:
Biochemical pharmacology
Indole alkaloids possess a large spectrum of biological activities including anti-protozoal action. Here we report for the first time that voacamine, isolated from the plant Tabernaemontana coronaria, is an antiprotozoal agent effective against a lar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b59bdef5c9bca75290344499f97e3f
https://doi.org/10.1016/j.bcp.2017.05.002
https://doi.org/10.1016/j.bcp.2017.05.002
Autor:
Joseane Lima Prado Godinho, Parasuraman Jaisankar, Jayaraman Vinayagam, Sara Teixeira de Macedo Silva, Hemanta K. Majumder, Aline Araujo Zuma, Juliany Cola Fernandes Rodrigues, Somenath Roy Chowdhury, Wanderley de Souza
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Kinetoplast DNA (kDNA) bearing unusual mitochondrion of trypanosomatid parasites offers a new paradigm in chemotherapy modality. Topoisomerase II of Leishmania donovani (LdTopII), a key enzyme associated with kDNA replication, is emerging as a potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633b73781ac61dd3a0dd874841846979
http://europepmc.org/articles/PMC6085290
http://europepmc.org/articles/PMC6085290
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80a8f9f89102c9159ea0f229058201dc
https://doi.org/10.1096/fasebj.2018.32.1_supplement.828.1
https://doi.org/10.1096/fasebj.2018.32.1_supplement.828.1