Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Somayya Manzoor"'
Autor:
Alastair Hotblack, Evangelia K. Kokalaki, Morgan J. Palton, Gordon Weng-Kit Cheung, Iwan P. Williams, Somayya Manzoor, Thomas I. Grothier, Alice Piapi, Valeria Fiaccadori, Patrycja Wawrzyniecka, Harriet A. Roddy, Giulia Agliardi, Claire Roddie, Shimobi Onuoha, Simon Thomas, Shaun Cordoba, Martin Pule
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Chimeric antigen receptor (CAR) T cells are a promising form of cancer immunotherapy, although they are often associated with severe toxicities. Here, we present a split-CAR design incorporating separate antigen recognition and intracellular
Externí odkaz:
https://doaj.org/article/dee4a8da64cb4a34bd085ebded529484
Autor:
Evangelia Kokalaki, Biao Ma, Mathieu Ferrari, Thomas Grothier, Warren Hazelton, Somayya Manzoor, Eren Costu, Julia Taylor, Anna Bulek, Saket Srivastava, Isaac Gannon, Ram Jha, Rosalind Gealy, Lukas Stanczuk, Tatiana Rizou, Mathew Robson, Mohamed El-Kholy, Vania Baldan, Matteo Righi, James Sillibourne, Simon Thomas, Shimobi Onuoha, Shaun Cordoba, Martin Pule
Publikováno v:
Molecular Therapy.
Autor:
Valeria Fiaccadori, Morgan J. Palton, Evangelia Kokalaki, Shaun Cordoba, Harriet Roddy, Shimobi Onuoha, Gordon Cheung, Iwan P. Williams, Claire Roddie, Alastair Hotblack, Giulia Agliardi, Thomas Grothier, Martin Pule, Patrycja Wawrzyniecka, Somayya Manzoor, Simon Thomas, Alice Piapi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Chimeric antigen receptor (CAR) T cells are a promising form of cancer immunotherapy, although they are often associated with severe toxicities. Here, we present a split-CAR design incorporating separate antigen recognition and intracellular signalin
Autor:
Anne Marijn Kramer, Juliana Silva, Rachel Richardson, Andre Lopes, Patrycja Wawrzyniecka, Robert Wynn, Kanchan Rao, Bilyana Popova, Shimobi Onuoha, Gulrukh Ahsan, Paul Veys, Jenny Yeung, Aleks Guvenel, Gary Wright, Giovanna Lucchini, Krystle Villanueva, Mathieu Ferrari, Farzin Farzaneh, Winston Vetharoy, Denise Bonney, Jack Bartram, Fernanda Castro, Leila Mekkaoui, Sara Ghorashian, Joan Casanovas-Company, Somayya Manzoor, Persis Amrolia, Jan Chu, Tony Brooks, Danielle Pinner, Kim Champion, Rachael Hough, Sarah J. Albon, Ajay Vora, Robert Chiesa, Nicholas Goulden, Arina Lazareva, Martin Pule, Kimberly Gilmour, Oana Ciocarlie, Sujith Samarasinghe, Gordon Weng-Kit Cheung, Sarah Inglott, Allan Hackshaw
Publikováno v:
Nature Medicine. 25:1408-1414
Chimeric antigen receptor (CAR)-modified T cells targeting CD19 demonstrate unparalleled responses in relapsed/refractory acute lymphoblastic leukemia (ALL)1–5, but toxicity, including cytokine-release syndrome (CRS) and neurotoxicity, limits broad
Autor:
Sara, Ghorashian, Anne Marijn, Kramer, Shimobi, Onuoha, Gary, Wright, Jack, Bartram, Rachel, Richardson, Sarah J, Albon, Joan, Casanovas-Company, Fernanda, Castro, Bilyana, Popova, Krystle, Villanueva, Jenny, Yeung, Winston, Vetharoy, Aleks, Guvenel, Patrycja A, Wawrzyniecka, Leila, Mekkaoui, Gordon Weng-Kit, Cheung, Danielle, Pinner, Jan, Chu, Giovanna, Lucchini, Juliana, Silva, Oana, Ciocarlie, Arina, Lazareva, Sarah, Inglott, Kimberly C, Gilmour, Gulrukh, Ahsan, Mathieu, Ferrari, Somayya, Manzoor, Kim, Champion, Tony, Brooks, Andre, Lopes, Allan, Hackshaw, Farzin, Farzaneh, Robert, Chiesa, Kanchan, Rao, Denise, Bonney, Sujith, Samarasinghe, Nicholas, Goulden, Ajay, Vora, Paul, Veys, Rachael, Hough, Robert, Wynn, Martin A, Pule, Persis J, Amrolia
Publikováno v:
Nature medicine. 25(9)
Chimeric antigen receptor (CAR)-modified T cells targeting CD19 demonstrate unparalleled responses in relapsed/refractory acute lymphoblastic leukemia (ALL)
Autor:
Thomas Grothier, Shimobi Onuoha, Biao Ma, Somayya Manzoor, Martin Pule, Shaun Cordoba, Evangelia Kokalaki, Eren Costu, Ram Jha, Warren Hazelton, Simon Thomas
Publikováno v:
Blood. 134:5747-5747
Background: CD22 is an attractive target for Chimeric Antigen Receptor (CAR) since it is expressed by most B-cell malignancies. However, CAR targeting of CD22 is challenging since CD22 has a long ectodomain of 300 Å, which is several times wider tha
Autor:
Rajesh Karattil, Anna Marta Bulek, Martin Pule, Reyisa Bughda, Mathieu Ferrari, Simon Thomas, Shaun Cordoba, Paul Maciocia, Somayya Manzoor, Biao Ma, Shimobi Onuoha, Patrycja Wawrzyniecka, Alex Kinna, Saket Srivastava
Publikováno v:
Blood. 132:1661-1661
Introduction Mature T cell lymphomas are aggressive, treatment resistant cancers that are associated with poor prognosis. Clinical application of immunotherapeutic approaches has been limited by a lack of target antigens that discriminate malignant f