Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Somayah S. Elsayed"'
Autor:
Isabel Nuñez Santiago, Nataliia V. Machushynets, Marija Mladic, Doris A. van Bergeijk, Somayah S. Elsayed, Thomas Hankemeier, Gilles P. van Wezel
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Microbial natural products form the basis of most of the antibiotics used in the clinic. The vast majority has not yet been discovered, among others because the hidden chemical space is obscured by previously identified (and typically abunda
Externí odkaz:
https://doaj.org/article/0c87ac983fb441bc8d63c0baaabb8440
Autor:
Somayah S. Elsayed, Helga U. van der Heul, Xiansha Xiao, Aleksi Nuutila, Laura R. Baars, Changsheng Wu, Mikko Metsä-Ketelä, Gilles P. van Wezel
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Angucyclines are type II polyketide natural products, often characterized by unusual structural rearrangements through B- or C-ring cleavage of their tetracyclic backbone. While the enzymes involved in B-ring cleavage have been extensively s
Externí odkaz:
https://doaj.org/article/552e4cdb804544a5861a5f3671f524ed
Autor:
Mandy B. Hulst, Le Zhang, Helga U. van der Heul, Chao Du, Somayah S. Elsayed, Arina Koroleva, Thadee Grocholski, Dennis P. A. Wander, Mikko Metsä-Ketelä, Jacques J. C. Neefjes, Gilles P. van Wezel
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Introduction: Daunorubicin and doxorubicin, two anthracycline polyketides produced by S. peucetius, are potent anticancer agents that are widely used in chemotherapy, despite severe side effects. Recent advances have highlighted the potential of prod
Externí odkaz:
https://doaj.org/article/4df9c2d97b6a46d0a40d7261af1249f7
Autor:
Jack Jansma, Nicola U. Thome, Markus Schwalbe, Anastasia Chrysovalantou Chatziioannou, Somayah S. Elsayed, Gilles P. van Wezel, Pieter van den Abbeele, Saskia van Hemert, Sahar El Aidy
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTThe gut microbiota plays a pivotal role in health and disease. The use of probiotics as microbiota-targeted therapies is a promising strategy to improve host health. However, the molecular mechanisms involved in such therapies are often not w
Externí odkaz:
https://doaj.org/article/aefc9eaf089d4395beb16aea36d020a3
Autor:
Doris A. van Bergeijk, Somayah S. Elsayed, Chao Du, Isabel Nuñez Santiago, Anna M. Roseboom, Le Zhang, Victor J. Carrión, Herman P. Spaink, Gilles P. van Wezel
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-12 (2022)
The biosynthetic gene clusters of Actinobacteria are poorly expressed in the laboratory, necessitating a better understanding of the signals that promote their expression in order to exploit their full biosynthetic potential. Here, the authors show t
Externí odkaz:
https://doaj.org/article/38cafff306da48aa90a4c69594586c68
Autor:
Nataliia V. Machushynets, Somayah S. Elsayed, Chao Du, Maxime A. Siegler, Mercedes de la Cruz, Olga Genilloud, Thomas Hankemeier, Gilles P. van Wezel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Streptomycetes are major producers of bioactive natural products, including the majority of the naturally produced antibiotics. While much of the low-hanging fruit has been discovered, it is predicted that less than 5% of the chemical space
Externí odkaz:
https://doaj.org/article/936e287858154edda7e76a3907273f6b
Autor:
Karol Al Ayed, Denise Zamarbide Losada, Nataliia V. Machushynets, Barbara Terlouw, Somayah S. Elsayed, Julian Schill, Vincent Trebosc, Michel Pieren, Marnix H. Medema, Gilles P. van Wezel, Nathaniel I. Martin
Publikováno v:
ACS Infectious Diseases 9 (2023) 4
ACS Infectious Diseases, 9(4), 739-748
ACS Infectious Diseases, 9(4), 739-748
The unabated rise of antibiotic resistance has raised the specter of a post-antibiotic era and underscored the importance of developing new classes of antibiotics. The relacidines are a recently discovered group of nonribosomal lipopeptide antibiotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8b1f8dc30b226e87fcbcb3a89f3277
https://doi.org/10.1021/acsinfecdis.3c00043
https://doi.org/10.1021/acsinfecdis.3c00043
Autor:
Jack Jansma, Nicola U. Thome, Markus Schwalbe, Anastasia Chrysovalantou Chatziioannou, Somayah S. Elsayed, Gilles P. van Wezel, Pieter van den Abbeele, Saskia van Hemert, Sahar El Aidy
The gut microbiota plays a pivotal role in health and disease. The use of probiotics as microbiota-targeted therapies is a promising strategy to improve host health. However, dynamic molecular mechanisms are often not elucidated, especially when targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ade563a261d3a11f36325f0a8d1aceb
https://doi.org/10.1101/2023.01.29.525861
https://doi.org/10.1101/2023.01.29.525861
Autor:
Doris A. van Bergeijk, Hannah E. Augustijn, Somayah S. Elsayed, Joost Willemse, Victor J. Carrión, Mia Urem, Lena V. Grigoreva, Maksim Y. Cheprasov, Semyon Grigoriev, Bas Wintermans, Andries E. Budding, Herman P. Spaink, Marnix H. Medema, Gilles P. van Wezel
Ancient microbial communities of permafrost soils and frozen animal remains represent an archive that has barely been explored. This yet unexplored microbial world is a vast resource that can provide us with new evolutionary insights, metabolic pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::432c94bcb012bd24ecbbf14af8e41485
https://doi.org/10.1101/2022.12.22.521380
https://doi.org/10.1101/2022.12.22.521380
Autor:
Peter H. Nibbering, Somayah S. Elsayed, Wietse de Boer, Gilles P. van Wezel, Maxime A. Siegler, Thomas Hankemeier, Grégory Genta-Jouve, Víctor J. Carrión
Publikováno v:
The Journal of Organic Chemistry
Journal of organic chemistry, 85(16), 10648-10657. American Chemical Society
Journal Of Organic Chemistry (0022-3263) (Amer Chemical Soc), 2020-08, Vol. 85, N. 16, P. 10648-10657
Journal of Organic Chemistry 85 (2020) 16
Journal of Organic Chemistry, 85(16), 10648-10657. AMER CHEMICAL SOC
Journal of Organic Chemistry, 85(16), 10648-10657
Journal of organic chemistry, 85(16), 10648-10657. American Chemical Society
Journal Of Organic Chemistry (0022-3263) (Amer Chemical Soc), 2020-08, Vol. 85, N. 16, P. 10648-10657
Journal of Organic Chemistry 85 (2020) 16
Journal of Organic Chemistry, 85(16), 10648-10657. AMER CHEMICAL SOC
Journal of Organic Chemistry, 85(16), 10648-10657
More than half of all antibiotics and many other bioactive compounds are produced by the actinobacterial members of the genus Streptomyces. It is therefore surprising that virtually no natural products have been described for its sister genus Strepta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a509269b41a568abbc93d4a812790da
http://europepmc.org/articles/PMC7497648
http://europepmc.org/articles/PMC7497648