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Autor:
Susan Krueger, Yuzhuo Chu, Cynthia B. Peterson, Vladimir N. Uversky, Christopher B. Stanley, Joseph E. Curtis, Letitia O Puster
Publikováno v:
Biochemistry
Small-angle neutron scattering (SANS) measurements were pursued to study human vitronectin, a protein found in tissues and the circulation that regulates cell adhesion/migration and proteolytic cascades that govern hemostasis and pericellular proteol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68437bd301401987b0451b3c505deeb4
https://doi.org/10.1021/acs.biochem.9b00605
https://doi.org/10.1021/acs.biochem.9b00605
Publikováno v:
Protein Sci
The serine protease inhibitor, plasminogen activator inhibitor Type‐1 (PAI‐1) is a metastable protein that undergoes an unusual transition to an inactive conformation with a short half‐life of only 1–2 hr. Circulating PAI‐1 is bound to a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7280981b72529c03f1cc8a6e43ac758a
https://doi.org/10.1002/pro.3770
https://doi.org/10.1002/pro.3770
Autor:
Deepa Suhag, Jahangeer Ahmed, Sonu Gandhi, Saad M. Alshehri, Veerbhan Kesarwani, Deepshikha Shahdeo
Publikováno v:
Carbohydrate polymers. 266
Targeting cell surface receptors for specific drug delivery in cancer has garnered lot of attention. Urokinase plasminogen activator receptor (uPAR), a surface biomarker, is overexpressed on many tumours including breast, colorectal, prostate, and ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1af1c388fcb10830d64cb133a4f19b5
https://pubmed.ncbi.nlm.nih.gov/35287884
https://pubmed.ncbi.nlm.nih.gov/35287884
Autor:
Cynthia B. Peterson, Yuzhuo Chu, Gregory L. Ware, Carlee S. McClintock, Joseph P. Emerson, Kayla D. McConnell, Joel C. Bucci
Publikováno v:
Journal of Biological Inorganic Chemistry
Components of the fibrinolytic system are subjected to stringent control to maintain proper hemostasis. Central to this regulation is the serpin plasminogen activator inhibitor-1 (PAI-1), which is responsible for specific and rapid inhibition of fibr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee8bb773c7a0f89278d23551fbd29a2
https://doi.org/10.1007/s00775-017-1489-5
https://doi.org/10.1007/s00775-017-1489-5
Publikováno v:
Fish & Shellfish Immunology. 65:9-16
Vitronectin (Vtn) is a multifunctional protein that plays significant roles in cell adhesion, migration, spreading and survival, and in the regulation of membrane attack complex formation and the terminal pathway of complement activation in innate im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0523370de77402ed9bb33f9b4b3b0ac4
https://doi.org/10.1016/j.fsi.2017.03.055
https://doi.org/10.1016/j.fsi.2017.03.055
Publikováno v:
Toxins
Volume 11
Issue 11
Toxins, Vol 11, Iss 11, p 625 (2019)
Volume 11
Issue 11
Toxins, Vol 11, Iss 11, p 625 (2019)
(1) Background. Snake venom phosphodiesterases (SVPDEs) are among the least studied venom enzymes. In envenomation, they display various pathological effects, including induction of hypotension, inhibition of platelet aggregation, edema, and paralysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157df14fa557cbe0a701118b7a244e17
Autor:
Mairead Kiely, Louise C. Kenny, Babette S. Zemel, Michael P. Caulfield, Michael J. McPhaul, Jonathan O'b Hourihane, Deirdre M. Murray, Alan D. Irvine, Colin P. Hawkes, Adda Grimberg
Publikováno v:
Pediatric research
Background: Insulin-like growth factor (IGF)-I and -II play an important role in prenatal growth. During the first 2 months from birth, body fat doubles, and rapid weight gain during this time increases future risk of cardiometabolic disease. The aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66087c4d2f421c283133977c3dfc4d7a
https://pubmed.ncbi.nlm.nih.gov/30745570
https://pubmed.ncbi.nlm.nih.gov/30745570
Autor:
Nicolai Sidenius, Baoyu Zhao, Zhipu Luo, Rui Li, Sonu Gandhi, Valentina De Lorenzi, Michael Ploug, Mingdong Huang, Henrik Gårdsvoll, Cai Yuan
Publikováno v:
Journal of Molecular Biology. 427:1389-1403
The urokinase-type plasminogen activator receptor (uPAR) is a multidomain glycolipid-anchored membrane protein, which facilitates extracellular matrix remodeling by focalizing plasminogen activation to cell surfaces via its high-affinity interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816400add6fed04285847c97c42fcec0
https://doi.org/10.1016/j.jmb.2015.01.022
https://doi.org/10.1016/j.jmb.2015.01.022
Autor:
Irene Martín-Estal, Elena Ávila-Gallego, José Luis González-Guerra, Gabriel A. Aguirre, Miriam Granado, Inma Castilla-Cortázar, Juan E. Puche, Angel Luis García-Villalón, Úrsula Muñoz
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181760 (2017)
PLoS ONE
PLoS ONE
Circulating levels of IGF-1 may decrease under several circumstances like ageing, metabolic syndrome, and advanced cirrhosis. This reduction is associated with insulin resistance, dyslipidemia, progression to type 2 diabetes, and increased risk for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05900d0b612515aa920927d1bd2edd1
http://europepmc.org/articles/PMC5555709?pdf=render
http://europepmc.org/articles/PMC5555709?pdf=render