Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Somatic mutation analysis"'
Autor:
Xinglin Wen, Beining Yin, Li Lin, Long Liu, Siyuan Weng, Hui Xu, Yuyuan Zhang, Jinhai Deng, Ruiying Liao, Cungeng Fan
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Background Immune checkpoint inhibitors (ICIs) have greatly improved cancer treatment, but the role of genes related to T cell-mediated tumor killing (TTK) sensitivity in ovarian cancer (OV) is unclear. Methods This study analyzed 1367 OV pa
Externí odkaz:
https://doaj.org/article/b7a2682a1af34873bc976ad56db2b1ae
Autor:
Haiyu Zhang, Weisheng Huang, Mutong Chen, Yuhan Liu, Bing Yan, Shuanzhu Mou, Wendong Jiang, Hongbing Mei
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Genes involved in drug absorption, distribution, metabolism, and excretion (ADME) are named ADME genes. However, the comprehensive role of ADME genes in kidney renal clear cell carcinoma (KIRC) remains unclear. Using the clinical and gene ex
Externí odkaz:
https://doaj.org/article/e6886460a42a4c2abd55f8e3799542a2
Akademický článek
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Akademický článek
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Autor:
Rostislav Skitchenko, Yulia Dinikina, Sergey Smirnov, Mikhail Krapivin, Anna Smirnova, Daria Morgacheva, Mykyta Artomov
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
Medulloblastoma (MB) is the most common pediatric brain tumor which accounts for about 20% of all pediatric brain tumors and 63% of intracranial embryonal tumors. MB is considered to arise from precursor cell populations present during an early brain
Externí odkaz:
https://doaj.org/article/f9c9462376b140498df088ed230390c8
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundIn the regulation of tumor-related immunity, dendritic cells (DCs) are crucial sentinel cells; they are powerful to present antigens and initiate immune responses. Therefore, we concentrated on investigating the DC-related gene profile, pro
Externí odkaz:
https://doaj.org/article/318169b5a0a54e628ff70d5d84694c8b
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Accurate and robust somatic mutation detection is essential for cancer treatment, diagnostics and research. Various analysis pipelines give different results and thus should be systematically evaluated. In this study, we benchmarked 5 commonly-used s
Externí odkaz:
https://doaj.org/article/1a3b7a3c82094670accfc4c7d64e7ffb
Autor:
Brigitte Pelzmann, Ahmed Hatab, Susanne Scheruebel, Sonja Langthaler, Theresa Rienmueller, Armin Sokolowski, Astrid Gorischek, Dieter Platzer, Klaus Zorn-Pauly, Stephan W. Jahn, Thomas Bauernhofer, Wolfgang Schreibmayer
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
A search in the GDC Data Portal revealed 304 documented somatic mutations of the KCNJ3 gene in primary tumors (out of 10.202 cases). Most affected tumor types were carcinomas from uterus, skin and lung, while breast cancer exerted the lowest number o
Externí odkaz:
https://doaj.org/article/25e751d727e649c9b262bb838d06b3f1
Autor:
Alice Debernardi, Aurélia Meurisse, Jean-Luc Prétet, David Guenat, Franck Monnien, Laurie Spehner, Angélique Vienot, Patrick Roncarati, Thierry André, Laurent Abramowitz, Chloé Molimard, Christiane Mougin, Michael Herfs, Stefano Kim, Christophe Borg
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Squamous Cell Carcinoma of the Anal canal (SCCA) is a rare disease associated with a Human Papillomavirus (HPV) infection in most cases, predominantly the HPV16 genotype. About 15% of SCCA are diagnosed in metastatic stage and some will relapse after
Externí odkaz:
https://doaj.org/article/7ae7ddd728064f5fa3ee2a3a4e2107d0
Autor:
Wei-feng Hong, Mou-yuan Liu, Li Liang, Yang Zhang, Zong-juan Li, Keqi Han, Shi-suo Du, Yan-jie Chen, Li-heng Ma
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundAlthough checkpoint blockade is a promising approach for the treatment of hepatocellular carcinoma (HCC), subsets of patients expected to show a response have not been established. As T cell-mediated tumor killing (TTK) is the fundamental p
Externí odkaz:
https://doaj.org/article/118ff0155b4f4d7ba059f8f09f153fca