Zobrazeno 1 - 10
of 3 772
pro vyhledávání: '"Somatic evolution"'
Publikováno v:
eLife, Vol 12 (2024)
In asexual populations that don’t undergo recombination, such as cancer, deleterious mutations are expected to accrue readily due to genome-wide linkage between mutations. Despite this mutational load of often thousands of deleterious mutations, ma
Externí odkaz:
https://doaj.org/article/fdb8cd79eb9c48c1b55d351cb94b5f02
Akademický článek
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Autor:
Fabio Marongiu, James DeGregori
Publikováno v:
Molecular Oncology, Vol 16, Iss 18, Pp 3238-3258 (2022)
Aging represents the major risk factor for the development of cancer and many other diseases. Recent findings show that normal tissues become riddled with expanded clones that are frequently driven by cancer‐associated mutations in an aging‐depen
Externí odkaz:
https://doaj.org/article/4b794a98bd4d4e10a91080afb90bc231
Publikováno v:
Physics, Vol 4, Iss 3, Pp 812-832 (2022)
We consider spatial population dynamics on a lattice, following a type of a contact (birth–death) stochastic process. We show that simple mathematical approximations for the density of cells can be obtained in a variety of scenarios. In the case of
Externí odkaz:
https://doaj.org/article/b081ea07f8854006a1282b1b3cfa3344
Autor:
Lisa Dressler, Michele Bortolomeazzi, Mohamed Reda Keddar, Hrvoje Misetic, Giulia Sartini, Amelia Acha-Sagredo, Lucia Montorsi, Neshika Wijewardhane, Dimitra Repana, Joel Nulsen, Jacki Goldman, Marc Pollitt, Patrick Davis, Amy Strange, Karen Ambrose, Francesca D. Ciccarelli
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-22 (2022)
Abstract Background Genetic alterations of somatic cells can drive non-malignant clone formation and promote cancer initiation. However, the link between these processes remains unclear and hampers our understanding of tissue homeostasis and cancer d
Externí odkaz:
https://doaj.org/article/4b436b928b4743e792fdece120c80bb3
Autor:
Artem Mikelov, Evgeniia I Alekseeva, Ekaterina A Komech, Dmitry B Staroverov, Maria A Turchaninova, Mikhail Shugay, Dmitriy M Chudakov, Georgii A Bazykin, Ivan V Zvyagin
Publikováno v:
eLife, Vol 11 (2022)
The stability and plasticity of B cell-mediated immune memory ensures the ability to respond to the repeated challenges. We have analyzed the longitudinal dynamics of immunoglobulin heavy chain repertoires from memory B cells, plasmablasts, and plasm
Externí odkaz:
https://doaj.org/article/abfef42b83a945a8a9be7f4644f92e8d
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/1997e13562cc4ba6a24fffd08587dd8f
Autor:
James DeGregori
Publikováno v:
Evolutionary Applications, Vol 13, Iss 7, Pp 1784-1790 (2020)
Abstract This special issue of evolutionary applications focused on the evolution of cancer has provided a wealth of different viewpoints and results from leaders in the field. Together, these papers emphasize the importance of a broad perspective in
Externí odkaz:
https://doaj.org/article/dc5e8a49a32e4387baa8903d94eb0518
Publikováno v:
Evolutionary Applications, Vol 13, Iss 7, Pp 1550-1557 (2020)
Abstract Precision medicine relies on targeting specific somatic alterations present in a patient's tumor. However, the extent to which germline ancestry may influence the somatic burden of disease has received little attention. We estimated the gene
Externí odkaz:
https://doaj.org/article/9cb6b161812942a09a54248b8af6d820
Autor:
Andrii I. Rozhok, James DeGregori
Publikováno v:
Evolutionary Applications, Vol 13, Iss 7, Pp 1569-1580 (2020)
Abstract Tumors result from genetic and epigenetic alterations that change cellular survival and differentiation probabilities, promoting clonal dominance. Subsequent genetic and selection processes in tumors allow cells to lose their tissue fidelity
Externí odkaz:
https://doaj.org/article/1b368865b3f64151ac4c8aab21838ae3