Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Somasish Ghosh Dastidar"'
Autor:
Shuo-Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Lim, Hristelina Ilieva, Philippe A Parone, Sheue-Houy Tyan, Tsemay M Tse, Jer-Cherng Chang, Oleksandr Platoshyn, Ngoc B Bui, Anh Bui, Anne Vetto, Shuying Sun, Melissa McAlonis-Downes, Joo Seok Han, Debbie Swing, Katannya Kapeli, Gene W Yeo, Lino Tessarollo, Martin Marsala, Christopher E Shaw, Greg Tucker-Kellogg, Albert R La Spada, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Don W Cleveland
Publikováno v:
eLife, Vol 8 (2019)
Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation. We show here that broad expression within the nervous system of wild-type or either o
Externí odkaz:
https://doaj.org/article/04213ee8809d4946acefc96cd36ba9b2
Autor:
Don W. Cleveland, Amy Taylor, Albert R. La Spada, Clotilde Lagier-Tourenne, Jie Jiang, Tania F. Gendron, Sandra Diaz Garcia, Huaxi Xu, John Ravits, Somasish Ghosh Dastidar, Lu-Lin Jiang, Leonard Petrucelli, Melissa McAlonis-Downes, María José Cubillas Rodríguez, Patrick King, Sandrine Da Cruz, Qiang Zhu, Yong Jie Zhang
Publikováno v:
Nature Neuroscience. 23:615-624
Hexanucleotide expansions in C9orf72, which encodes a predicted guanine exchange factor, are the most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although repeat expansion has been established to g
Autor:
Sarah Jordan, Steven G. Yeom, Bryce L. Sopher, Matthew B. Mitchell, Angela Chang, Michael T. Pham, Somasish Ghosh Dastidar, Albert R. La Spada
Publikováno v:
J Neurosci
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 40, iss 45
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 40, iss 45
Decline of protein quality control in neurons contributes to age-related neurodegenerative disorders caused by misfolded proteins. 4E-BP1 is a key node in the regulation of protein synthesis, as activated 4E-BP1 represses global protein translation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02cb92b2edf9b98c884389495087ae27
https://europepmc.org/articles/PMC7643294/
https://europepmc.org/articles/PMC7643294/
Autor:
Mandheer Wadhwa, Craig L. Bennett, Albert R. La Spada, Somasish Ghosh Dastidar, Shuo-Chien Ling, Matthew B. Mitchell, Yingzhang Chen, Michael A. van Es, Linda Greensmith, Travis D. Ashe, Bilal Malik, Changwoo Lee, Christopher Grunseich, Bryce L. Sopher, Derek B. Miller, Don W. Cleveland
Publikováno v:
Acta Neuropathologica. 136:425-443
Amyotrophic lateral sclerosis type 4 (ALS4) is a rare, early-onset, autosomal dominant form of ALS, characterized by slow disease progression and sparing of respiratory musculature. Dominant, gain-of-function mutations in the senataxin gene (SETX) ca
Autor:
Qiang, Zhu, Jie, Jiang, Tania F, Gendron, Melissa, McAlonis-Downes, Lulin, Jiang, Amy, Taylor, Sandra, Diaz Garcia, Somasish, Ghosh Dastidar, Maria J, Rodriguez, Patrick, King, Yongjie, Zhang, Albert R, La Spada, Huaxi, Xu, Leonard, Petrucelli, John, Ravits, Sandrine, Da Cruz, Clotilde, Lagier-Tourenne, Don W, Cleveland
Publikováno v:
Nature neuroscience. 23(5)
Hexanucleotide expansions in C9orf72, which encodes a predicted guanine exchange factor, are the most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although repeat expansion has been established to g
Autor:
Michael J. MacCoss, Somasish Ghosh Dastidar, Tony Chen, Nathan Basisty, Albert R. La Spada, Michael T. Chin, Dao-Fu Dai, Ying Ann Chiao, Richard P. Beyer, Peter S. Rabinovitch, Yonggang Liu, Pabalu P. Karunadharma
Publikováno v:
GeroScience. 41(6)
Inhibition of mammalian target of rapamycin complex I (mTORC1) by rapamycin improves cardiac function in both aging and heart failure. While the protective mechanisms are not fully understood in mammals, they are presumably mediated through metabolic
Autor:
Martin Marsala, Shuying Sun, Ngoc B. Bui, Tsemay M. Tse, Shuo-Chien Ling, Greg Tucker-Kellogg, Gene W. Yeo, Philippe A. Parone, Hristelina Ilieva, Seiya Tokunaga, Christopher Shaw, Sandrine Da Cruz, Oleksandr Platoshyn, Kenneth Lim, Somasish Ghosh Dastidar, Don W. Cleveland, Clotilde Lagier-Tourenne, Debbie Swing, Joo Seok Han, Albert R. La Spada, Anh Bui, Wan Yun Ho, Lino Tessarollo, Jer-Cherng Chang, Melissa McAlonis-Downes, Sheue-Houy Tyan, Anne P. Vetto, Katannya Kapeli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6336cbcf1decdbc907883e7a0b14a4f7
https://doi.org/10.7554/elife.40811.039
https://doi.org/10.7554/elife.40811.039
Autor:
Lizbeth Leon Martinez, Somasish Ghosh Dastidar, Christian Michael Viray, Albert R. La Spada, Elizabeth Del Greco, Emmeline C. Academia, Travis D. Ashe, Joanna M. Sitzmann, Kaili Lia Carr, Ariana A. Rodriguez, Brian K. Kennedy, Brian Kaplowitz, Shih-Yin Tsai
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1903-1914 (2016)
SummaryObesity is a major risk factor driving the global type II diabetes pandemic. However, the molecular factors linking obesity to disease remain to be elucidated. Gender differences are apparent in humans and are also observed in murine models. H
Autor:
Kenneth Lim, Shuying Sun, Sandrine Da Cruz, Debbie Swing, Wan Yun Ho, Philippe A. Parone, Ngoc B. Bui, Jer Cherng Chang, Clotilde Lagier-Tourenne, Joo Seok Han, Albert R. La Spada, Hristelina Ilieva, Anh Bui, Melissa McAlonis-Downes, Katannya Kapeli, Don W. Cleveland, Seiya Tokunaga, Greg Tucker-Kellogg, Martin Marsala, Christopher Shaw, Oleksandr Platoshyn, Somasish Ghosh Dastidar, Tsemay M. Tse, Shuo-Chien Ling, Gene W. Yeo, Sheue Houy Tyan, Lino Tessarollo, Anne P. Vetto
Publikováno v:
Autophagy
eLife, Vol 8 (2019)
eLife
eLife, Vol 8 (2019)
eLife
Coding or non-coding mutations in FUS (fused in sarcoma) cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In addition to familial ALS, abnormal aggregates of FUS are present in a portion of FTD and other neurodegenerative
Autor:
Luís Pereira de Almeida, Somasish Ghosh Dastidar, Christine Esau, Brian Spencer, Albert R. La Spada, Sónia Duarte, Kimberlee M. Fischer, B. Nelson Chau, Eliezer Masliah, Stevan Djakovic, Bradley E. Morrison, Amy N. Dubinsky, Deidre Mackenna, Bryce L. Sopher, Terry Gaasterland, Cynthia Hsu, Rabaab Zahra, Travis D. Ashe
Publikováno v:
Cell Metabolism. 20:626-638
SummaryMacroautophagy (hereafter autophagy) is the major pathway by which macromolecules and organelles are degraded. Autophagy is regulated by the mTOR signaling pathway—the focal point for integration of metabolic information, with mTORC1 playing