Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Somaia S. Abd El-Karim"'
Autor:
Heba T. Abdel-Mohsen, Manal M. Anwar, Nesreen S. Ahmed, Somaia S. Abd El-Karim, Sameh H. Abdelwahed
Publikováno v:
Molecules, Vol 29, Iss 4, p 875 (2024)
Cancer is a complicated, multifaceted disease that can impact any organ in the body. Various chemotherapeutic agents have a low selectivity and are very toxic when used alone or in combination with others. Resistance is one of the most important hurd
Externí odkaz:
https://doaj.org/article/75a0f2516ad84188bb2f621cfdf97360
Autor:
Somaia S. Abd El-Karim, Ahlam H. Mahmoud, Asmaa K. Al-Mokaddem, Noha E. Ibrahim, Hamad M. Alkahtani, Amer Alhaj Zen, Manal M. Anwar
Publikováno v:
Molecules, Vol 28, Iss 19, p 6814 (2023)
Osteoarthritis is a substantial burden for patients with the disease. The known medications for the disease target the mitigation of the disease’s symptoms. So, drug development for the management of osteoarthritis represents an important challenge
Externí odkaz:
https://doaj.org/article/47b64a550ab3407abfe261a0d20bd602
Autor:
Yasmin M. Syam, Manal M. Anwar, Somaia S. Abd El-Karim, Khaled M. Elokely, Sameh H. Abdelwahed
Publikováno v:
Molecules, Vol 27, Iss 15, p 4924 (2022)
Herein, 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline was used as a bio-isosteric scaffold to the phthalazinone motif of the standard drug Olaparib to design and synthesize new derivatives of potential PARP-1 inhibitory activity using the 6-sulfonohydrazid
Externí odkaz:
https://doaj.org/article/bb43890996e44af8bc37aa2d8e5e274d
Autor:
Mona O. Sarhan, Somaia S. Abd El-Karim, Manal M. Anwar, Raghda H. Gouda, Wafaa A. Zaghary, Mohammed A. Khedr
Publikováno v:
Molecules, Vol 26, Iss 8, p 2273 (2021)
Novel 6-bromo-coumarin-ethylidene-hydrazonyl-thiazolyl and 6-bromo-coumarin-thiazolyl-based derivatives were synthesized. A quantitative structure activity relationship (QSAR) model with high predictive power r2 = 0.92, and RMSE = 0.44 predicted five
Externí odkaz:
https://doaj.org/article/26be2dc592cf4a98a26c8592b0570102
Autor:
Manal M. Anwar, Somaia S. Abd El-Karim, Ahlam H. Mahmoud, Abd El-Galil E. Amr, Mohamed A. Al-Omar
Publikováno v:
Molecules, Vol 24, Iss 13, p 2413 (2019)
Breast cancer is considered the most common and deadly cancer among women worldwide. Nanomedicine has become extremely attractive in the field of cancer treatment. Due to the high surface to volume ratio and other unique properties, nanomaterials can
Externí odkaz:
https://doaj.org/article/7126c3f28d2c4f27bfcb0f804f06914a
Autor:
Eman S. Nossier, Somaia S. Abd El-Karim, Nagy M. Khalifa, Ali S. El-Sayed, Emad S. I. Hassan, Salwa M. El-Hallouty
Publikováno v:
Molecules, Vol 23, Iss 12, p 3074 (2018)
A series of novel 1,3,4-triarylpyrazoles containing different heterocycles has been prepared, characterized and screened for their in vitro antiproliferative activity against HePG-2, MCF-7, PC-3, A-549 and HCT-116 cancer cell lines. The biological re
Externí odkaz:
https://doaj.org/article/28749109074d4d9e9e538561308a3057
Autor:
Nagy M. Khalifa, Aladdin M. Srour, Somaia S. Abd El-Karim, Dalia O. Saleh, Mohamed A. Al-Omar
Publikováno v:
Molecules, Vol 22, Iss 11, p 1820 (2017)
A new series of 2-alkyloxy-pyridine-3-carbonitrile-benzofuran hybrids (4a–x) was synthesized. All the new derivatives were examined via the standard technique for their vasodilation activity. Some of the investigated compounds exhibited a remarkabl
Externí odkaz:
https://doaj.org/article/8de825bf071044b09f641dcd3db3fc87
Autor:
Manal M. Anwar, Somaia S. Abd El-Karim, Basma M. Essa, Samia A. Elseginy, Tamer M. Sakr, Yasmin M. Syam
Publikováno v:
RSC Advances. 11:36989-37010
The current work represents the design and synthetic approaches of a new set of compounds 6–10 bearing the 1,4-dimethyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide scaffold. The biological evaluation revealed that most of the new compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c927cac1007ec3287061db880f609fca
https://doi.org/10.1039/d1ra06799k
https://doi.org/10.1039/d1ra06799k
A new set of thiazolyl-pyrazolines 3a–l was prepared by cyclization of carbothioamides 2a–g with phenacyl bromide and/or 4-bromo phenacyl bromide. The new chemical entities were tested for their antimicrobial properties, while none of the tested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26f1c068c49cb405d837c0a1abd8038
Autor:
Ismail M. M. Othman, Zahra M. Alamshany, Nada Y. Tashkandi, Mohamed A. M. Gad-Elkareem, Somaia S. Abd El-Karim, Eman S. Nossier
Publikováno v:
RSC advances. 12(1)
Deregulation of various protein kinases is considered as one of the important factors resulting in cancer development and metastasis, thus multi-targeting the kinase family is one of the most important strategies in current cancer therapy. This conte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0a0b949fcb1a1fb632d00dd1b85df6
https://pubmed.ncbi.nlm.nih.gov/35424523
https://pubmed.ncbi.nlm.nih.gov/35424523