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Regulation of myosin light chain phosphorylation by RhoB in neuronal cells

Autor: Brian J. Morris, Ann-Marie Conway, Soma Rakhit, E.M. O’Kane, Allan James

Publikováno v: Experimental Cell Research. 300:35-42

The phosphorylation of myosin light chain (MLC) is a key regulatory point in the control of cellular morphology. Evidence suggests that RhoA-a member of the Rho GTPase family-regulates MLC phosphorylation via Rho kinase (ROK). Neurones display subtle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c1b1b486a99f52680f0173df6b6221
https://doi.org/10.1016/j.yexcr.2004.06.022

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Tethering of the Platelet-derived Growth Factor β Receptor to G-protein-coupled Receptors

Autor: Forbes Alderton, Kok Choi Kong, Timothy M. Palmer, Soma Rakhit, Balwinder Sambi, Susan Pyne, Nigel J. Pyne

Publikováno v: Journal of Biological Chemistry. 276:28578-28585

Here we provide evidence to show that the platelet-derived growth factor β receptor is tethered to endogenous G-protein-coupled receptor(s) in human embryonic kidney 293 cells. The tethered receptor complex provides a platform on which receptor tyro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60c4741d5f864ac1a1ad87128077c2a3
https://doi.org/10.1074/jbc.m102771200

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Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase

Autor: Ann-Marie CONWAY, Soma RAKHIT, Susan PYNE, Nigel J. PYNE

Publikováno v: Biochemical Journal. 337:171-177

The mechanism used by the platelet-derived growth factor receptor (PDGFR) to activate the mitogen-activated- protein-kinase (p42/p44 MAPK) pathway was investigated in cultured airway smooth muscle (ASM) cells. We have found that pertussis toxin (PTX,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bb3ca5ccdd494de7e8d7618e305197c
https://doi.org/10.1042/bj3370171

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Calcium-dependent regulation of membrane ion permeability in a cell line derived from the equine sweat gland epithelium

Autor: Douglas L. Bovell, John D. Pediani, Soma Rakhit, Wing-Hung Ko, S M Wilson, James A. Nichol

Publikováno v: Comparative Biochemistry and Physiology Part A: Physiology. 111:215-221

We measured the rates of 125 I − and 86 Rb + efflux from preloaded, cultured equine sweat gland cells. The calcium ionophore ionomycin increased the efflux of both isotopes. Anion efflux was unaffected by Ba 2+ , but this cation inhibited 86 Rb + -

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15abe93986bc25c847f43c9fee2e4244
https://doi.org/10.1016/0300-9629(95)00011-u

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N-methyl-D-aspartate and brain-derived neurotrophic factor induce distinct profiles of extracellular signal-regulated kinase, mitogen- and stress-activated kinase, and ribosomal s6 kinase phosphorylation in cortical neurons

Autor: Soma Rakhit, Celestine T. O'Shaughnessy, Brian J. Morris, Catherine J Clark

Publikováno v: Molecular pharmacology. 67(4)

Stimulation of N -methyl-d-aspartate (NMDA) receptors is believed to underlie long-term memory formation, and excessive NMDA receptor activation has been linked to several neuropathological conditions. Phosphorylation and activation of p42/44 mitogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd737b0b5482fa303186aa2cdad5ac0
https://pubmed.ncbi.nlm.nih.gov/15625280

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Extracellular actions of sphingosine I-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis

Autor: Ann-Marie Conway, Soma Rakhit, Nigel J. Pyne, Susan Pyne, Peter I. Darroch, Rothwelle J. Tate, Amanda E. McKie

Publikováno v: Biochemical Society transactions. 27(4)

Sphingosine 1-phosphate (SIP) belongs to a group of platelet-derived lipid mediators that regulate cell differentiation, survival and proliferation. It is released from platelets after their activation with agents such as thrombin [l]. In addition, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c53cc7e7b57bdcb1cc98d415b1fec9d
https://pubmed.ncbi.nlm.nih.gov/10917611

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The platelet-derived growth factor receptor stimulation of p42/p44 mitogen-activated protein kinase in airway smooth muscle involves a G-protein-mediated tyrosine phosphorylation of Gab1

Autor: Nigel J. Pyne, Soma Rakhit, Susan Pyne

Publikováno v: Molecular pharmacology. 58(2)

Using cultured airway smooth muscle cells, we showed previously that the platelet-derived growth factor (PDGF) receptor uses the G-protein, G(i), to stimulate Grb-2-associated phosphoinositide 3-kinase (PI3K) activity. We also showed that this was an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babe7711ffd9eaff9af10b636eca87b5
https://pubmed.ncbi.nlm.nih.gov/10908310

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Pyrimidine nucleotide-evoked inhibition of cyclic AMP accumulation in equine epithelial cells

Autor: Anna L. Remsbury, Marie Gallagher, Soma Rakhit, S M Wilson, Wing-Hung Ko

Publikováno v: Experimental physiology. 84(4)

Uridine triphosphate (UTP) evoked inhibition of adrenaline-evoked cAMP accumulation in cultured equine epithelial cells (EC50, 1.8 +/- 0.2 microM) and this effect was mimicked by 5-Br-UTP (EC50, 6.6 +/- 1.8 microM) and uridine diphosphate (UDP; EC50,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3346d66a3abb1864a9f9ad57bd0cbbda
https://pubmed.ncbi.nlm.nih.gov/10481222

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