Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Solvig Diederichs"'
Autor:
Solvig Diederichs, Simon I. Dreher, Sarah Anna Nüesch, Sven Schmidt, Christian Merle, Wiltrud Richter
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background In vitro chondrogenesis of mesenchymal stromal cells (MSCs) driven by the essential chondro-inducer transforming growth factor (TGF)-β is instable and yields undesired hypertrophic cartilage predisposed to bone formation in vivo.
Externí odkaz:
https://doaj.org/article/c05f8ba30a654773992e8de861edb4b3
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151412- (2024)
Mesenchymal stromal cells (MSCs) that are promising for cartilage tissue engineering secrete high amounts of prostaglandin E2 (PGE2), an immunoactive mediator involved in endochondral bone development. This study aimed to identify drivers of PGE2 and
Externí odkaz:
https://doaj.org/article/0b22007cc1e84674bca396163ffb215f
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Background Fully functional regeneration of skeletal defects by multipotent progenitor cells requires that differentiating cells gain the specific mechano-competence needed in the target tissue. Using cartilage neogenesis as an example, we a
Externí odkaz:
https://doaj.org/article/fb24adb1ed744926808a84df4d837739
Publikováno v:
Cells, Vol 12, Iss 12, p 1659 (2023)
Elaborate bioreactor cultivation or expensive growth factor supplementation can enhance extracellular matrix production in engineered neocartilage to provide sufficient mechanical resistance. We here investigated whether raising extracellular calcium
Externí odkaz:
https://doaj.org/article/499d9c5e19d247e687a1885290704c06
Autor:
Felicia A. M. Klampfleuthner, Benedict Lotz, Tobias Renkawitz, Wiltrud Richter, Solvig Diederichs
Publikováno v:
Cells, Vol 11, Iss 19, p 2965 (2022)
Differentiating mesenchymal stromal cells (MSCs) into articular chondrocytes (ACs) for application in clinical cartilage regeneration requires a profound understanding of signaling pathways regulating stem cell chondrogenesis and hypertrophic degener
Externí odkaz:
https://doaj.org/article/b5d7dda19d7d4ead9653a86ce8a6346c
Autor:
Marietta Herrmann, Solvig Diederichs, Svitlana Melnik, Jana Riegger, Drenka Trivanović, Shushan Li, Zsuzsa Jenei-Lanzl, Rolf E. Brenner, Markus Huber-Lang, Frank Zaucke, Frank A. Schildberg, Susanne Grässel
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)
The incidence of musculoskeletal diseases is steadily increasing with aging of the population. In the past years, extracellular vesicles (EVs) have gained attention in musculoskeletal research. EVs have been associated with various musculoskeletal pa
Externí odkaz:
https://doaj.org/article/174cbfd129a943ed8a6564560b186d55
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Mesodermal differentiation of induced pluripotent stem cells (iPSCs) in vitro and subsequent specification into mesodermal derivatives like chondrocytes is currently afflicted with a substantial cell loss that severely limits tissue yield. More knowl
Externí odkaz:
https://doaj.org/article/0294b2d6225b4663a1995843b18ad6d3
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Guiding progenitor cell development between chondral versus endochondral pathways is still an unachieved task of cartilage neogenesis, and human mesenchymal progenitor cell (MPC) chondrogenesis is considered as a valuable model to better understand h
Externí odkaz:
https://doaj.org/article/79ac17833fb94a86b94d6c8288125e03
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
A major problem with chondrocytes derived in vitro from stem cells is undesired hypertrophic degeneration, to which articular chondrocytes (ACs) are resistant. As progenitors of all adult tissues, induced pluripotent stem cells (iPSCs) are in theory
Externí odkaz:
https://doaj.org/article/50f6ef050fb74db0bd72fd92aa6541f4
Publikováno v:
Cellular Physiology and Biochemistry, Vol 33, Iss 6, Pp 1607-1619 (2014)
Aim: Main objective was to investigate whether the synthetic retinoic acid receptor (RAR)-β antagonist LE135 is able to drive in vitro chondrogenesis of human mesenchymal stromal cells (MSCs) or improve differentiation by suppressing hypertrophic ch
Externí odkaz:
https://doaj.org/article/07e0a1aae424440cab02d24a9f6d6fb2