Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Solveig G. Schmidt"'
Autor:
Solveig G. Schmidt, Mette Galsgaard Malle, Anne Kathrine Nielsen, Søren S.-R. Bohr, Ciara F. Pugh, Jeppe C. Nielsen, Ida H. Poulsen, Kasper D. Rand, Nikos S. Hatzakis, Claus J. Loland
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The dopamine transporter, DAT, controls dopamine signaling by facilitating its reuptake using the Na+ gradient as driving force. Here, the authors uncover that an antiport of K+ ions also contributes to setting the rate of DAT-mediated dopamine clear
Externí odkaz:
https://doaj.org/article/639e6c6d3fb94ff895a426dc699efbb4
Autor:
Christian B. Billesbølle, Jonas S. Mortensen, Azmat Sohail, Solveig G. Schmidt, Lei Shi, Harald H. Sitte, Ulrik Gether, Claus J. Loland
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The neurotransmitter transporter SERT counter transport K+ to transport serotonin. Here the authors show that the activity of the prokaryotic orthologue LeuT is also modulated by this cation, suggesting a general regulatory role for K+on neutrotrasmi
Externí odkaz:
https://doaj.org/article/5c07a915d81b45039bdbbb7f2201b43f
Publikováno v:
eLife, Vol 12 (2024)
The neurotransmitter:sodium symporters (NSSs) are secondary active transporters that couple the reuptake of substrate to the symport of one or two sodium ions. One bound Na+ (Na1) contributes to the substrate binding, while the other Na+ (Na2) is tho
Externí odkaz:
https://doaj.org/article/b541b07cee2b4b2bb93fdbec258eadb3
The neurotransmitter:sodium symporters (NSSs) are secondary active transporters that couple the reuptake of substrate to the symport of one or two sodium ions. One bound Na+(Na1) contributes to the substrate binding, while the other Na+(Na2) is thoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ab728592e8f419f710cc2826819185c
https://doi.org/10.1101/2023.04.04.535525
https://doi.org/10.1101/2023.04.04.535525
Publikováno v:
Neurochemical Research. 47:127-137
Sodium-coupled neurotransmitter transporters play a fundamental role in the termination of synaptic neurotransmission, which makes them a major drug target. The reconstitution of these secondary active transporters into liposomes has shed light on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3cfcb740270d4d335d2bea837a1f01b
https://doi.org/10.1007/s11064-021-03413-y
https://doi.org/10.1007/s11064-021-03413-y
Publikováno v:
Calugareanu, D, Möller, I R, Schmidt, S G, Loland, C J & Rand, K D 2022, ' Probing the impact of temperature and substrates on the conformational dynamics of the Neurotransmitter:Sodium symporter LeuT ', Journal of Molecular Biology, vol. 434, no. 2, 167356 . https://doi.org/10.1016/j.jmb.2021.167356
The crucial function of neurotransmitter:sodium symporters (NSS) in facilitating the reuptake of neurotransmitters into neuronal cells makes them attractive drug targets for treating multiple mental diseases. Due to the challenges in working with euk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c57a9c41be580f09ef6c7b34f3337c7
https://curis.ku.dk/ws/files/285945982/Probing_the_Impact_of_Temperature_and_Substrates_on_the_Conformational_Dynamics_of_the_Neurotransmitter.pdf
https://curis.ku.dk/ws/files/285945982/Probing_the_Impact_of_Temperature_and_Substrates_on_the_Conformational_Dynamics_of_the_Neurotransmitter.pdf
Autor:
Solveig G. Schmidt, Ciara Pugh, Claus J. Loland, Ida Poulsen, Søren S.-R. Bohr, Nikos S. Hatzakis, Mette Galsgaard Malle, Anne K. Nielsen, Kasper D. Rand, Jeppe Nielsen
The dopamine transporter (DAT) facilitates dopamine reuptake from the extracellular space, and thereby terminates neurotransmission and refills cellular stores of dopamine. DAT belongs to the neurotransmitter:sodium symporter (NSS) family, which incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17fafff9b629483e6599949072798626
https://doi.org/10.21203/rs.3.rs-1043992/v1
https://doi.org/10.21203/rs.3.rs-1043992/v1
Publikováno v:
Neurochemical research. 47(1)
Sodium-coupled neurotransmitter transporters play a fundamental role in the termination of synaptic neurotransmission, which makes them a major drug target. The reconstitution of these secondary active transporters into liposomes has shed light on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::511c62b37b165e4781a273fedfd5817e
https://pubmed.ncbi.nlm.nih.gov/34347265
https://pubmed.ncbi.nlm.nih.gov/34347265
Autor:
Kasper D. Rand, Claus J. Loland, Ingvar R. Möller, Patrick S. Merkle, Solveig G. Schmidt, Dionisie Calugareanu, Gerard Comamala
Publikováno v:
Journal of Proteomics. 225:103845
Neurotransmitter:sodium symporters (NSS) are integral membrane proteins (IMP), responsible for reuptake of neurotransmitters from the synaptic cleft. Due to challenges in production of mammalian NSS in their active form, the prokaryotic hydrophobic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5278cfb70e55e3edaa9342eb758068b
https://doi.org/10.1016/j.jprot.2020.103845
https://doi.org/10.1016/j.jprot.2020.103845