Zobrazeno 1 - 10 of 53 pro vyhledávání: '"Solubilitat"'
1
Assessing the Solubility of Baricitinib and Drug Uptake in Different Tissues Using Absorption and Fluorescence Spectroscopies
Autor: Roya Mohammadi-Meyabadi, Negar Beirampour, Núria Garrós, Helen Lissette Alvarado, David Limón, Marcelle Silva-Abreu, Ana Cristina Calpena, Mireia Mallandrich
Publikováno v: Pharmaceutics; Volume 14; Issue 12; Pages: 2714
The low water solubility of baricitinib (BCT) limits the development of new formulations for the topical delivery of the drug. The aims of this study were to assess the solubility of BCT in different solvents, including Transcutol, a biocompatible pe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710c2086592b380de0cfcb81fe8be976
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2
The solubility of helium in lead–lithium eutectic alloy
Autor: Sedano, Luis Angel, Esteban Alcalá, Gustavo Adolfo, Cavaro, Matthieu, Iraola de Acevedo, Eduardo, AL AWAD, Abdulrahman, Batet, Lluís, Guasch, M.
Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
instname
Digital.CSIC. Repositorio Institucional del CSIC
The helium production rates in liquid metals (Pb-Li eutectic alloy, LLE and others) Blanket Breeders (BB) are nearly mol-to-mol linked to tritium and intimately associated with the compulsory requirement of high tritium self-sufficiency of next fusio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8087d7cf91b6a63cde59d7cb06bc11
https://hdl.handle.net/2117/375212
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3
Synthesis and characterization of a new norfloxacin/resorcinol cocrystal with enhanced solubility and dissolution profile
Autor: Hanan Fael, Rafael Barbas, Rafel Prohens, Clara Ràfols, Elisabet Fuguet
Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Pharmaceutics
Pharmaceutics, Vol 14, Iss 49, p 49 (2022)
Pharmaceutics; Volume 14; Issue 1; Pages: 49
A new cocrystal of Norfloxacin, a poorly soluble fluoroquinolone antibiotic, has been synthetized by a solvent-mediated transformation experiment in toluene, using resorcinol as a coformer. The new cocrystal exists in both anhydrous and monohydrate f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a11af3690a6f0f7a0655579d1fd9db1
http://hdl.handle.net/2445/184757
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4
Edible films and coatings formulated with arrowroot starch as a non-conventional starch source for plums packaging
Autor: Gislaine Ferreira Nogueira, Gabriela Ragazzi Santana dos Santos, Juliana Viegas da Silva, Cyntia Trevisan Soares, Farayde Matta Fakhouri, Bianca de Oliveira Leme, Patricia Barbosa Nascimento, Rafael Augustus de Oliveira
Publikováno v: Polysaccharides
Volume 2
Issue 2
Pages 24-386
Polysaccharides, Vol 2, Iss 24, Pp 373-386 (2021)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Increasing environmental awareness has promoted an interest in alternative strategies to common plastics obtained from fossil sources, stimulating research on the use of biodegradable and edible films/coatings obtained from renewable sources such as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fef428e3fcd41d133e497868cdcdfe
https://hdl.handle.net/2117/358856
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5
Equations for the Correlation and Prediction of Partition Coefcients of Neutral Molecules and Ionic Species in the Water-Isopropanol Solvent System
Autor: Clara Ràfols, Martí Rosés, William E. Acree, Michael H. Abraham
Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
We use literature data on solubilities of 46 compounds in the water-isopropanol (IPA) system to obtain the corresponding partition coefficients, P, for transfer from water to water- IPA mixtures. We have then used our previously constructed linear fr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25baf6cd1cc285cc214f64fddad9f58
http://hdl.handle.net/2445/184953
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6
Ionizable drug self-associations and the solubility dependence on pH: detection of aggregates in saturated solutions using mass spectrometry (ESI-Q-TOF-MS/MS)
Autor: Alex Avdeef, Xavier Subirats, Clara Ràfols, Elisabeth Bosch, Elisabet Fuguet
Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
It is widely accepted that solubility-pH profiles of ionizable compounds follow the Henderson-Hasselbalch equation. However, several studies point out that compounds often undergo additional processes in saturated solutions, such as sub-micellar olig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ad9a522ed578617d6ab4b83a55cadf
http://hdl.handle.net/2445/178187
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8
Solubility and Dissolution Rate of Active Pharmaceutical Ingredients: Dissolution Media and Effect of Enhancers
Autor: Lucero Borja, Diego Sebastián
Publikováno v: TDX (Tesis Doctorals en Xarxa)
TDR: Tesis Doctorales en Red
CBUC, CESCA
TDR. Tesis Doctorales en Red
Consejo Superior de Investigaciones Científicas (CSIC)
Dipòsit Digital de la UB
Universidad de Barcelona
[eng] The present doctoral thesis is focused on the effect of pH, enhancers and biorelevant media in the Solubility and the Dissolution Rates of some selected acidic active pharmaceutical ingredients (API). Because of the effect of these physicochemi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1fc890ef579cc30a68f9a154cbcd78b5
http://hdl.handle.net/10803/671762
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9
Determination of the aqueous pKa of very insoluble drugs by capillary electrophoresis: Internal standards for methanol-water extrapolation
Autor: Albishri, Abdulkarim, Cabot, Joan M., Fuguet i Jordà, Elisabet, Rosés Pascual, Martí
Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
A fast determination of acidity constants (pKa) of very insoluble drugs has become a necessity in drug discovery process because it often produces molecules that are highly lipophilic and sparingly soluble in water. In this work the high throughput i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b1d5eea0e415acf410cc05e2e58186
https://doi.org/10.1016/j.chroma.2021.462795
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10
Improved understanding of aqueous solubility modeling through topological data analysis
Autor: Mahesan Niranjan, Jacek Brodzki, Jeremy G. Frey, Francisco Belchi Guillamon, Lee Steinberg, Mariam Pirashvili
Publikováno v: Journal of Cheminformatics, Vol 10, Iss 1, Pp 1-14 (2018)
Digital.CSIC. Repositorio Institucional del CSIC
instname
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
Journal of Cheminformatics
Topological data analysis is a family of recent mathematical techniques seeking to understand the ‘shape’ of data, and has been used to understand the structure of the descriptor space produced from a standard chemical informatics software from t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202108bfd04911b88052f1753743d9f3
http://link.springer.com/article/10.1186/s13321-018-0308-5
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