Výsledky vyhledávání - "Solomon S. Klioze"

Efficacy and Safety of CP-945,598, a Selective Cannabinoid CB1 Receptor Antagonist, on Weight Loss and Maintenance

Autor: Nick Finer, John D. Obourn, Richard D. England, Priscilla Hollander, Solomon S. Klioze, Robert J. Fountaine, Louis J. Aronne, Robert Chew, Coralie M. Powell

Publikováno v: Obesity. 19:1404-1414

Three double-blind, placebo-controlled, three-parallel-group, multicenter phase 3 trials were conducted to assess the efficacy and safety of CP-945,598 for weight loss and weight-loss maintenance. Two trials were designed to be 2 years in duration (i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6308da5ae8071be96414dd7839a6be5a
https://doi.org/10.1038/oby.2010.352

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Two-Year Pulmonary Safety and Efficacy of Inhaled Human Insulin (Exubera) in Adult Patients With Type 2 Diabetes

Autor: Julio Rosenstock, William T. Cefalu, Priscilla A. Hollander, Andre Belanger, Freddy G. Eliaschewitz, Jorge L. Gross, Solomon S. Klioze, Lisa B. St. Aubin, Howard Foyt, Masayo Ogawa, William T. Duggan

Publikováno v: Diabetes Care

OBJECTIVE—The purpose of this study was to evaluate the 2-year pulmonary safety of inhaled human insulin (Exubera [EXU]) in 635 nonsmoking adults with type 2 diabetes. RESEARCH DESIGN AND METHODS—Patients were randomly assigned to receive prandia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab49da0a8758cf51d14d52b70a0c05f
http://europepmc.org/articles/PMC2518332

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Two-Year Safety and Efficacy of Inhaled Human Insulin (Exubera) in Adult Patients With Type 1 Diabetes

Autor: Masayo Ogawa, Howard Foyt, Julio Rosenstock, Solomon S. Klioze, Priscilla A. Hollander, Freddy G. Eliaschewitz, Lisa St Aubin, William T. Cefalu, Jorge Luiz Gross, André Bélanger, William T. Duggan

Publikováno v: Diabetes Care. 30:579-585

OBJECTIVE—The purpose of this study was to evaluate the long-term (2-year) safety and efficacy of inhaled human insulin (Exubera [insulin human (rDNA origin)] inhalation powder) (EXU) in adult patients with type 1 diabetes. RESEARCH DESIGN AND METH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51eb05041ddf6ce45a37f35308d339c
https://doi.org/10.2337/dc06-1863

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Tiotropium in patients with moderate COPD naive to maintenance therapy: a randomised placebo-controlled trial

Autor: Frank C. Sciurba, Nikos M Siafakas, Thierry Troosters, Santosh Sutradhar, Marc Decramer, Solomon S. Klioze, Idelle Weisman, Carla Yunis

Publikováno v: NPJ Primary Care Respiratory Medicine

The benefits of pharmacotherapy with tiotropium HandiHaler 18 μg for patients with chronic obstructive pulmonary disease (COPD) have been previously demonstrated. However, few data exist regarding the treatment of moderate disease (Global Initiative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3b5f9946ecf19387f723bc4f160265
https://lirias.kuleuven.be/handle/123456789/455216

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Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 1

Autor: Lawrence L. Martin, Solomon S. Klioze, Victor J. Bauer, David Hoffman, Harry M. Geyer, W Raymond Kosley, Brian J. Duffy, Arthur R. McFadden, Helen H. Ong

Publikováno v: Journal of Medicinal Chemistry. 19:1315-1324

Synthesis of 1'-methyl-3-phenylspiro[isobenzofuran-1(3H),4'-piperidine] (7a, HP 365) and the demethyl analogue 9a (HP 505) was prompted by recognition of an aminoalkyl(aryl)isobenzofuran moiety common to the antidepressants talopram (Lu 3-010) and tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::345228f0781225c59eac1ba03c476690
https://doi.org/10.1021/jm00233a012

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Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 2. Compounds containing a heteroatom attached to nitrogen

Autor: Solomon S. Klioze, Victor J. Bauer, Harry M. Geyer

Publikováno v: Journal of medicinal chemistry. 20(4)

The synthesis and antitetrabenazine activity of a series of N-heteroatom derivatives of 3-phenylspiro[isobenzofuran-1,4'-piperidines] are reported. Optimal antitetrabenazine activity is associated with compounds containing a sterically unhindered, ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81442c760316efb90f2d6a5e5d3868be
https://pubmed.ncbi.nlm.nih.gov/850252

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