Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Solomon R. Pollack"'
Publikováno v:
Biophysical Journal. 91:3097-3112
Fibroblast growth factor 2 (FGF2) can enhance the proliferative capacity of bone and bone marrow stromal cells; however, the mechanisms behind this effect are not well described. We present a whole-cell kinetic model relating receptor-mediated bindin
Publikováno v:
Proceedings of the National Academy of Sciences. 101:11203-11208
An important issue in tissue engineering concerns the possibility of limited tissue ingrowth in tissue-engineered constructs because of insufficient nutrient transport. We report a dynamic flow culture system using high-aspect-ratio vessel rotating b
Quantitative analysis of three-dimensional fluid flow in rotating bioreactors for tissue engineering
Autor:
Solomon R. Pollack, Edward A. Botchwey, Eric D. Johnston, Elliot M. Levine, Cato T. Laurencin
Publikováno v:
Journal of Biomedical Materials Research. :205-215
Tissue engineering has emerged as a viable alternative to the problem of organ and tissue shortage. Our laboratory has developed matrices for bone tissue engineering based on sintered spherical particles and, using bioreactor technology, has demonstr
Publikováno v:
The Journal of Bone and Joint Surgery-American Volume. 83:1514-1523
Background: Electrical stimulation is used to treat nonunions and to augment spinal fusions. We studied the biochemical pathways that are activated in signal transduction when various types of electrical stimulation are applied to bone cells. Methods
Publikováno v:
Journal of Biomedical Materials Research. 55:242-253
A novel approach was utilized to grow in vitro mineralized bone tissue using lighter-than-water, polymeric scaffolds in a high aspect ratio rotating bioreactor. We have adapted polymer microencapsulation methods for the formation of hollow, lighter-t
Publikováno v:
Journal of Biomechanics. 33:1585-1591
We investigated the effect of newborn bovine serum on the intracellular calcium [Ca(2+)](i) response of primary cultured bone cells stimulated by fluid flow. As it has been previously established that these cells exhibit [Ca(2+)](i) responses to flui
Publikováno v:
Tissue Engineering. 6:519-530
The equations of motion for microcarriers in a rotating bioreactor have been formulated and trajectories obtained using numerical techniques. An imaging system was built to validate the results by direct observation of microcarrier trajectories in th
Publikováno v:
Journal of Biomedical Materials Research. 54:454-461
This study investigated the effect of fibronectin adsorption on surface charge variations and calcium phosphate (Ca-P) layer formation kinetics on the surface of 45S5 bioactive glass (BG). We hypothesize that the adsorption of fibronectin on BG chang
Autor:
Solomon R. Pollack, Kirk A. Reinbold
Publikováno v:
Bioelectromagnetics. 18:203-214
Primary-culture bone cells were exposed to ion-resonance (IR) magnetic fields tuned to Ca{sup 2+}. Cytosolic calcium concentration, [Ca{sup 2+}]{sub c}, was measured by using fura-2 during field exposure. The fields investigated were 20 {micro}T stat
Autor:
Solomon R. Pollack, Robert D. Goldman
Publikováno v:
Bioelectromagnetics. 17:445-449
The dermal equivalent matrix (DEM) is well recognized as an in vitro model of wound healing. To quantify the low-frequency (10-100 Hz) electric fields that cause proliferative effects in this model, determination of conductivity is a prerequisite. Th