Safety and Efficacy of Ruxolitinib in Patients with Myelofibrosis and Low Platelet Counts (50 – 100 × 109/L): Final Analysis of an Open-Label Phase 2 Study

Autor: Deanna Kornacki, Moshe Talpaz, Josef T. Prchal, Jason Clark, Srdan Verstovsek, Solomon I. Hamburg, Philomena Colucci, Murat O. Arcasoy, Lawrence B. Afrin

Publikováno v: Clinical lymphoma, myeloma & leukemia, vol 22, iss 5

Introduction : Treatment options in patients with myelofibrosis (MF) presenting with thrombocytopenia are limited. Final results of the phase 2 study (NCT01348490) of ruxolitinib in patients with MF and low baseline platelet counts (50–100 × 109/L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94046ef5631ff28960cc9d2663ea757
https://doi.org/10.1016/j.clml.2021.10.016

Splenic Infarction Associated with Anti-Car diolipin Antibody: A Report of Two Cases

Autor: Carie L. Mcvay, Yibin Zhang, Albert Ko, Leslie Memsic, Solomon I. Hamburg, Leon Morgenstern, Allan W. Silberman

Publikováno v: The American Surgeon. 70:71-74

There are few cases of splenic infarction associated with antiphospholipid antibody reported in the literature. We present two cases of splenic infarction associated with anticardiolipin antibody, one complicated by the development of a splenic pseud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8f3b4a1cea721589c431635a411a947
https://doi.org/10.1177/000313480407000117

Interim analysis of safety and efficacy of ruxolitinib in patients with myelofibrosis and low platelet counts

Autor: Gregory L. Ortega, Ronald Paquette, Wei Peng, Moshe Talpaz, Peter O'Neill, Srdan Verstovsek, Kavita Natrajan, Josef T. Prchal, Lawrence B. Afrin, Lance Leopold, Roger M. Lyons, Elliott F. Winton, Solomon I. Hamburg, Susan Erickson-Viitanen, Victor Sandor, Howard R. Terebelo, David F. Claxton, Ramon V. Tiu, Richard S. Levy, Olatoyosi Odenike, Katarzyna Jamieson, Hagop M. Kantarjian

Publikováno v: Journal of Hematology & Oncology
Talpaz, Moshe; Paquette, Ronald; Afrin, Lawrence; Hamburg, Solomon I; Prchal, Josef T; Jamieson, Katarzyna; et al.(2013). Interim analysis of safety and efficacy of ruxolitinib in patients with myelofibrosis and low platelet counts. Journal of Hematology & Oncology, 6(1), 81. doi: http://dx.doi.org/10.1186/1756-8722-6-81. Retrieved from: http://www.escholarship.org/uc/item/99h7n6j4

Background Ruxolitinib, a Janus kinase 1 and 2 inhibitor, demonstrated improvements in spleen volume, symptoms, and survival over placebo and best available therapy in intermediate-2 or high-risk myelofibrosis patients with baseline platelet counts �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8875371d13d13819de59c3343e0ccb
https://pubmed.ncbi.nlm.nih.gov/24283202

Laparoscopic Splenectomy for Hairy Cell Leukemia in Pregnancy

Autor: Moses Fallas, Marc H. Incerpi, Solomon I. Hamburg, Beni A. Adeniji, Dotun Ogunyemi, Robert Katz

Publikováno v: Case Reports in Medicine, Vol 2010 (2010)
Case Reports in Medicine

Objective. We present a successful case of laparoscopic splenectomy for a massively enlarged spleen at 25 weeks of gestation for hairy cell leukemia in pregnancy in a woman with initial hemoglobin of 4.3 gm/dl and platelet count of 18,000/mm3.Study D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed2b4c6556a3aaac8a124e52b981504
https://doaj.org/article/a85a235f3523474583bafa5921ee94cc

Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial

Autor: James B. Bussel, Vinod Pullarkat, Carlos Grande, Solomon I. Hamburg, Jeffrey S. Wasser, Robert L. Redner, Francis M. Senecal, Troy H. Guthrie, Terry Gernsheimer, J. Th. M. de Wolf, Emmanuelle Bourgeois, Lawrence Rice, Alan E. Lichtin, Janet L. Nichol, Miguel A. Sanz, Roger M. Lyons, Louis M. Aledort, Howard A. Liebman, Martin R. Schipperus, D. Matthew Guo, Francis J. Cuevas, David H. Henry, Craig M. Kessler, Michael D. Tarantino, Frank T. Slovick, James N. George, Howard R. Terebelo, David J. Kuter, François Lefrère, Ronald S. Go, Adrian C. Newland, Jean François Viallard

Publikováno v: LANCET, 371(9610), 395-403. ELSEVIER SCIENCE INC

Chronic immune thrombocytopenic purpura (ITP) is characterised by accelerated platelet destruction and decreased platelet production. Short-term administration of the thrombopoiesis-stimulating protein, romiplostim, has been shown to increase platele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7242ba239f9ec8b6d463654d6b2c19c
https://research.rug.nl/en/publications/2c07cd47-bc01-4461-96f4-7e7dc6ee9685