Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Solomon F. Ofori-Acquah"'
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Activation of Nrf2, a major transcription factor that drives the antioxidant defense system, is an emerging therapeutic strategy in Sickle Cell Disease (SCD). In this study, transgenic Sickle Cell Anemia mice (SS mice) treated with CDDO-Methyl (CDDO-
Externí odkaz:
https://doaj.org/article/4ad84528c53e42fab1956aea515b9f2e
Autor:
Katherine C. Wood, Brittany G. Durgin, Heidi M. Schmidt, Scott A. Hahn, Jeffrey J. Baust, Tim Bachman, Dario A. Vitturi, Samit Ghosh, Solomon F. Ofori-Acquah, Ana L. Mora, Mark T. Gladwin, Adam C. Straub
Publikováno v:
Blood Advances, Vol 3, Iss 23, Pp 4104-4116 (2019)
Abstract: Pulmonary and systemic vasculopathies are significant risk factors for early morbidity and death in patients with sickle cell disease (SCD). An underlying mechanism of SCD vasculopathy is vascular smooth muscle (VSM) nitric oxide (NO) resis
Externí odkaz:
https://doaj.org/article/b7619e205b9f4bd3ad6bf82a6e4b93ab
Autor:
Oluwabukola T. Gbotosho, Maria G. Kapetanaki, Samit Ghosh, Flordeliza S. Villanueva, Solomon F. Ofori-Acquah, Gregory J. Kato
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Emerging data indicate that free heme promotes inflammation in many different disease settings, including in sickle cell disease (SCD). Although free heme, proinflammatory cytokines, and cardiac hypertrophy are co-existing features of SCD, no mechani
Externí odkaz:
https://doaj.org/article/caf049baf99649c0b35ac33ae4a508ce
Autor:
Solomon F. Ofori-Acquah, Iris D. Buchanan, Ifeyinwa Osunkwo, Jerry Manlove-Simmons, Feyisayo Lawal, Alexander Quarshie, Arshed A. Quyyumi, Gary H. Gibbons, Beatrice E. Gee
Publikováno v:
Anemia, Vol 2012 (2012)
We studied the number and function of angiogenic progenitor cells and growth factors in children aged 5–18 years without acute illness, 43 with Hemoglobin SS and 68 with normal hemoglobin. Hemoglobin SS subjects had at least twice as many mononucle
Externí odkaz:
https://doaj.org/article/592bf53b9b7e43279d38cec6aa106e19
Publikováno v:
Anemia, Vol 2012 (2012)
Externí odkaz:
https://doaj.org/article/78d00e30061e4a08960bd0e56f7422cc
Publikováno v:
Anemia, Vol 2012 (2012)
Sickle cell disease (SCD) is characterized by chronic intravascular hemolysis that generates excess cell-free hemoglobin in the blood circulation. Hemoglobin causes multiple endothelial dysfunctions including increased vascular permeability, impaired
Externí odkaz:
https://doaj.org/article/85f9cde8d39a4d838661245d6c3d49e7
Autor:
Rimi Hazra, Hongjian Pu, Lesley M Foley, Lynda Little-Ihrig, T Kevin Hitchens, Samit Ghosh, Solomon F Ofori-Acquah, Xiaoming Hu, Enrico M Novelli
Publikováno v:
PNAS Nexus. 2
White-matter injury in sickle-cell disease (SCD) includes silent cerebral infarction diagnosed by diffusion tensor imaging (DTI), a complication associated with cognitive dysfunction in children with SCD. The link between white-matter injury and cogn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5360e0d101bd78e7b527d40292bb13b
https://doi.org/10.1093/pnasnexus/pgad149
https://doi.org/10.1093/pnasnexus/pgad149
Autor:
Mara Carreño, Maria F. Pires, Steven R. Woodcock, Tomasz Brzoska, Samit Ghosh, Sonia R. Salvatore, Fei Chang, Nicholas K. H. Khoo, Matthew Dunn, Nora Connors, Shuai Yuan, Adam C. Straub, Stacy G. Wendell, Gregory J. Kato, Bruce A. Freeman, Solomon F. Ofori-Acquah, Prithu Sundd, Francisco J. Schopfer, Dario A. Vitturi
Publikováno v:
Science advances. 8(26)
The up-regulation of kynurenine metabolism induces immunomodulatory responses via incompletely understood mechanisms. We report that increases in cellular and systemic kynurenine levels yield the electrophilic derivative kynurenine-carboxyketoalkene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc53acefca0e360f5b880e46faee37a0
https://pubmed.ncbi.nlm.nih.gov/35767602
https://pubmed.ncbi.nlm.nih.gov/35767602
Autor:
Adam C. Straub, Jianhai Du, Samit Ghosh, Heidi M Schmidt, Brenda McMahon, Jeffrey D. Lebensburger, Solomon F. Ofori-Acquah, Scott A. Hahn, Yekai Wang, Joo-Yeun Oh, Shuai Yuan, Katherine C. Wood, Jeffrey J. Baust, Sara E. Lewis, Dario A. Vitturi, Eric E. Kelley, Timothy N. Bachman, Rakesh P. Patel, Xena M. Williams
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Chronic hemolysis is a hallmark of sickle cell disease (SCD) and a driver of vasculopathy; however, the mechanisms contributing to hemolysis remain incompletely understood. Although XO (xanthine oxidase) activity has been shown to be eleva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfd0069750c45a3714c08181f7f9527
https://doi.org/10.1161/atvbaha.120.315081
https://doi.org/10.1161/atvbaha.120.315081
Autor:
Clement A. Adebamowo, Adebowale Adeyemo, Adeyinka Ashaye, Onoja M. Akpa, Tinashe Chikowore, Ananyo Choudhury, Yasmina J. Fakim, Segun Fatumo, Neil Hanchard, Michael Hauser, Braxton Mitchell, Nicola Mulder, Solomon F. Ofori-Acquah, Mayowa Owolabi, Michèle Ramsay, Bamidele Tayo, Archana Bhavani VasanthKumar, Yuji Zhang, Sally N. Adebamowo
Publikováno v:
Nat Genet
The Cardiometabolic Disorders in African-Ancestry Populations (CARDINAL) study site is a well-powered, first-of-its-kind resource for developing, refining and validating methods for research into polygenic risk scores that accounts for local ancestry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebb04568170b900c1197c9c1087ec41
https://europepmc.org/articles/PMC9907721/
https://europepmc.org/articles/PMC9907721/
