Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Solomon B. Margolin"'
Autor:
Ken J. Grattendick, Amy E Poulin Braim, Melinda H. MacDonald, M. L. Bruss, Solomon B. Margolin, Shri N. Giri
Publikováno v:
American Journal of Veterinary Research. 70:1031-1042
Objective—To characterize effects of IV administration of pirfenidone on clinical, biochemical, and hematologic variables and circulating tumor necrosis factor (TNF)-α concentrations in horses after infusion of a low dose of endotoxin. Animals—1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4643231896f99d4e3b5bcd459fe8168f
https://doi.org/10.2460/ajvr.70.8.1031
https://doi.org/10.2460/ajvr.70.8.1031
Autor:
Kendra C. Decile, Shri N. Giri, Edward S. Schelegle, Kent E. Pinkerton, Jim K. Mansoor, Jennifer M. Bratt, William F. Walby, Harinder Grewal, Solomon B. Margolin
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 20:660-668
Pirfenidone was administered to sensitized Brown Norway rats prior to a series of ovalbumin challenges. Airway hyperresponsiveness, inflammatory cell infiltration, mucin and collagen content, and the degree of epithelium and smooth muscle staining fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08297f341ce8289fc751f62760703b3d
https://doi.org/10.1016/j.pupt.2006.07.005
https://doi.org/10.1016/j.pupt.2006.07.005
Publikováno v:
The Journal of Heart and Lung Transplantation. 24:1577-1585
Background Obliterative bronchiolitis (OB) is the histologic correlate of chronic airway rejection, which remains the most significant cause of death in long-term survivors of lung transplantation. Using an established murine heterotopic tracheal tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6818328ca5f43d16c1937e0a0b9a69a1
https://doi.org/10.1016/j.healun.2004.11.002
https://doi.org/10.1016/j.healun.2004.11.002
Publikováno v:
Multiple Sclerosis Journal. 11:149-158
Currently, there are no approved treatments for secondary progressive multiple sclerosis (MS) that stabilize or reverse the neurological disabilities associated with this disease. Oral pirfenidone was found to stabilize and overcome the disabilities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3668c2095a36b31cab48b0639f3075b1
https://doi.org/10.1191/1352458505ms1134oa
https://doi.org/10.1191/1352458505ms1134oa
Publikováno v:
Nephrology Dialysis Transplantation. 20:71-82
The antifibrotic substance pirfenidone and the angiotensin II type I receptor antagonist candesartan cilexetil, given alone and in combination, were tested in rats with chronic anti-glomerular basement membrane glomerulonephritis (anti-GBM GN).Male W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61aeca533844315c4a32c9eaffb001bf
https://doi.org/10.1093/ndt/gfh562
https://doi.org/10.1093/ndt/gfh562
Autor:
Shawn Marshbank, Solomon B. Margolin, T. Mohanakumar, Martin D. Jendrisak, Felix G. Fernandez, Kishore Narayanan, Brice W. McKane
Publikováno v:
Transplantation. 77:664-669
Background. Chronic lung allograft rejection in the form of bronchiolitis obliterans syndrome and its histopathologic correlate, obliterative bronchiolitis (OB), are a major source of morbidity and mortality after lung transplantation. Murine heterot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35472d0624786fd26e260494ec1439da
https://doi.org/10.1097/01.tp.0000113162.48048.aa
https://doi.org/10.1097/01.tp.0000113162.48048.aa
Publikováno v:
Toxicological Sciences. 75:169-180
Pulmonary toxicity, including fibrosis, is a serious adverse effect associated with the antidysrhythmic drug amiodarone (AM). We tested the potential usefulness of pirfenidone against AM-induced pulmonary toxicity in the hamster model. Intratracheal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d153977c35654357f59bf35d4fc4b4
https://doi.org/10.1093/toxsci/kfg167
https://doi.org/10.1093/toxsci/kfg167
Publikováno v:
Multiple Sclerosis Journal. 9:280-283
Background: Pirfenidone is an oral medicatio n with a number of actions affecting the immune system. It has been proposed as a possible treatment for multiple sclerosis (MS). Methods: An early-phase study of progressive forms of MS was conducted. Pir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d352d5d204aef5edcd8a2160b26de3
https://doi.org/10.1191/1352458503ms907oa
https://doi.org/10.1191/1352458503ms907oa
Publikováno v:
Biochemical Pharmacology. 64:517-525
Renal fibrosis is a complication of kidney injury and can contribute to organ failure. Currently, there are no drugs for the treatment of renal fibrosis. Pirfenidone (PD) has been proven to have antifibrotic effects in animal models of fibrosis. We t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cff3a1f1c428d45c207154ab4c8bf4
https://doi.org/10.1016/s0006-2952(02)01213-3
https://doi.org/10.1016/s0006-2952(02)01213-3
Autor:
Andrew Fenning, Stevo Mirkovic, Solomon B Margolin, Anna J. Strachan, Stephen M. Taylor, Lindsay Brown, Anne-Marie L. Seymour
Publikováno v:
British Journal of Pharmacology. 135:961-968
1 This study has administered pirfenidone (5-methyl-l-phenyl-2-[1H]-pyridone) or amiloride to attenuate the remodelling and associated functional changes, especially an increased cardiac stiffness, in DOCA-salt hypertensive rats. 2 In control rats, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f111e7af5cffb1b9a8e7b1cb58d82a6d
https://doi.org/10.1038/sj.bjp.0704539
https://doi.org/10.1038/sj.bjp.0704539