Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease

Autor: Velez, J I, Chandrasekharappa, S C, Henao, E, Martinez, A F, Harper, U, Jones, M, Solomon, B D, Lopez, L, Garcia, G, Aguirre-Acevedo, D C, Acosta-Baena, N, Correa, J C, Lopera-Gomez, C M, Jaramillo-Elorza, M C, Rivera, D, Kosik, K S, Schork, N J, Swanson, J M, Lopera, F, Arcos-Burgos, M

Publikováno v: Velez, J I; Chandrasekharappa, S C; Henao, E; Martinez, A F; Harper, U; Jones, M; et al.(2012). Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease. Molecular Psychiatry, 18(5), 568-575. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/5fh7v0wm

The literature on GWAS (genome-wide association studies) data suggests that very large sample sizes (for example, 50,000 cases and 50,000 controls) may be required to detect significant associations of genomic regions for complex disorders such as Al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::779d461cc245b6056f08bb75eaaa892f
http://www.escholarship.org/uc/item/5fh7v0wm

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Exome Sequencing and High-Density Microarray Testing in Monozygotic Twin Pairs Discordant for Features of VACTERL Association.

Autor: Solomon, B. D., Pineda-Alvarez, D. E., Hadley, D. W., Hansen, N. F., Kamat, A., Donov, F. X., Chandrasekharappa, S. C., Hong, S. -K., Roessler, E., Mullikin, J. C.

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High Intellectual Function in Individuals with Mutation-Positive Microform Holoprosencephaly.

Autor: Solomon, B. D., Pineda-Alvarez, D. E., Gropman, A. L., Willis, M. J., Hadley, D. W., Muenke, M.

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