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pro vyhledávání: '"Solo Andrianomenjanahary"'
Autor:
Sofia Mitaku, Jean-Claude Jacquesy, Jean-Pierre Gesson, Xia Dong, Manfred Gerken, Klaus Bosslet, François Tillequin, Claude Monneret, Brigitte Renoux, Joerg Czech, Jean-Claude Florent, Sylvie Michel, Rainer Straub, Michel Koch, Martine Mondon, Solo Andrianomenjanahary, Gilbert Gaudel
Publikováno v:
Journal of medicinal chemistry. 41(19)
A series of new prodrugs of daunorubicin and doxorubicin which are candidates for antibody-directed enzyme prodrug therapy (ADEPT) is reported. These compounds (25a,b,c and 32a,b,c) have been designed to generate cytotoxic drugs after activation with