Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trial.

Autor: Porter JC; UCL Respiratory, University College London, London, United Kingdom.; University College London Hospitals NHS Trust, London, United Kingdom., Inshaw J; Exploristics, Belfast, Ireland., Solis VJ; University College London Hospitals NHS Trust, London, United Kingdom., Denneny E; UCL Respiratory, University College London, London, United Kingdom.; University College London Hospitals NHS Trust, London, United Kingdom., Evans R; University College London Hospitals NHS Trust, London, United Kingdom., Temkin MI; Antimicrobial Defence Lab, The Francis Crick Institute, London, United Kingdom., De Vasconcelos N; Antimicrobial Defence Lab, The Francis Crick Institute, London, United Kingdom., Aramburu IV; Antimicrobial Defence Lab, The Francis Crick Institute, London, United Kingdom., Hoving D; Antimicrobial Defence Lab, The Francis Crick Institute, London, United Kingdom., Basire D; UCL Respiratory, University College London, London, United Kingdom., Crissell T; University College London Hospitals NHS Trust, London, United Kingdom., Guinto J; University College London Hospitals NHS Trust, London, United Kingdom., Webb A; University College London Hospitals NHS Trust, London, United Kingdom., Esmail H; University College London Hospitals NHS Trust, London, United Kingdom.; National Institute for Health Research, University College London Hospital Biomedical Research Centre, London, United Kingdom., Johnston V; University College London Hospitals NHS Trust, London, United Kingdom.; National Institute for Health Research, University College London Hospital Biomedical Research Centre, London, United Kingdom., Last A; University College London Hospitals NHS Trust, London, United Kingdom.; Clinical Research Department, London School of Hygiene and Tropical Medicine, London, United Kingdom., Rampling T; University College London Hospitals NHS Trust, London, United Kingdom.; National Institute for Health Research, University College London Hospital Biomedical Research Centre, London, United Kingdom., Lippert L; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany., Helbig ET; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany., Kurth F; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany., Williams B; University College London Hospitals NHS Trust, London, United Kingdom.; National Institute for Health Research, University College London Hospital Biomedical Research Centre, London, United Kingdom., Flynn A; Exploristics, Belfast, Ireland., Lukey PT; Target to Treatment Consulting Ltd, Stevenage, United Kingdom., Birault V; Translation, The Francis Crick Institute, London, United Kingdom., Papayannopoulos V; Antimicrobial Defence Lab, The Francis Crick Institute, London, United Kingdom.

Publikováno v: ELife [Elife] 2024 Jul 16; Vol. 12. Date of Electronic Publication: 2024 Jul 16.