Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Solip Park"'
Autor:
Seulki Song, Youngil Koh, Seokhyeon Kim, Sang Mi Lee, Hyun Uk Kim, Jung Min Ko, Se-Hoon Lee, Sung-Soo Yoon, Solip Park
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background Despite the acceleration of somatic driver gene discovery facilitated by recent large-scale tumor sequencing data, the contribution of inherited variants remains largely unexplored, primarily focusing on previously known cancer pr
Externí odkaz:
https://doaj.org/article/feaa30f96f7c4840884dcfe8a4b7b203
Autor:
Youngil Koh, Hyemin Kim, So Young Joo, Seulki Song, Young Hoon Choi, Hyung Rae Kim, Byul Moon, Jamin Byun, Junshik Hong, Dong-Yeop Shin, Solip Park, Kwang Hyuck Lee, Kyu Taek Lee, Jong Kyun Lee, Daechan Park, Se-Hoon Lee, Jin-Young Jang, Hyunsook Lee, Jung-Ae Kim, Sung-Soo Yoon, Joo Kyung Park
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Lysosomes are closely linked to autophagic activity, which plays a vital role in pancreatic ductal adenocarcinoma (PDAC) biology. The survival of PDAC patients is still poor, and the identification of novel genetic factors for pro
Externí odkaz:
https://doaj.org/article/009bbecbecae404a8ed7c2e23cb50d90
Autor:
Mischan Vali-Pour, Solip Park, Jose Espinosa-Carrasco, Daniel Ortiz-Martínez, Ben Lehner, Fran Supek
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Abstract Somatic mutations are an inevitable component of ageing and the most important cause of cancer. The rates and types of somatic mutation vary across individuals, but relatively few inherited influences on mutation processes are known. We perf
Externí odkaz:
https://doaj.org/article/22847fd38e7c4b5e9fbc949293592c93
Autor:
Mischan Vali-Pour, Solip Park, Jose Espinosa-Carrasco, Daniel Ortiz-Martínez, Ben Lehner, Fran Supek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/5e25404880a54f40bb5df84528ce4de1
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
In the classic two-hit model, both alleles of a tumour suppressor gene need to be inactivated in order to promote cancer. Here, the authors challenge this model, finding that many cancer genes can be either one-hit or two-hit drivers depending on the
Externí odkaz:
https://doaj.org/article/18060ce218734a20a7039fa9bacb0dac
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103273- (2021)
Summary: Prefoldins (PFDNs) are evolutionary conserved co-chaperones, initially discovered in archaea but universally present in eukaryotes. PFDNs are prevalently organized into hetero-hexameric complexes. Although they have been overlooked since the
Externí odkaz:
https://doaj.org/article/3c4ed118909c47a88ceac3d61f2308f7
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Inherited germline variants and somatic mutations contribute to cancer. Here, the authors present the statistical method ALFRED that tests the two-hit hypothesis of tumorigenesis and apply it to ~10,000 tumor exomes to identify rare germline variants
Externí odkaz:
https://doaj.org/article/b2209a275b7640d6a293216d0efe4a65
Autor:
Solip Park, Ben Lehner
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 7, Pp 1-10 (2015)
Abstract Cancers, like many diseases, are normally caused by combinations of genetic alterations rather than by changes affecting single genes. It is well established that the genetic alterations that drive cancer often interact epistatically, having
Externí odkaz:
https://doaj.org/article/261b2557d490427a850c5d708cd15902
Autor:
Solip Park, Ben Lehner
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp 1-7 (2013)
Abstract Reduced activity of two genes in combination often has a more detrimental effect than expected. Such epistatic interactions not only occur when genes are mutated but also due to variation in gene expression, including among isogenic individu
Externí odkaz:
https://doaj.org/article/5f40f7cd008b417398cc082b5d229b4b
Publikováno v:
Molecular Systems Biology, Vol 7, Iss 1, Pp 1-11 (2011)
Abstract Proteins targeting the same subcellular localization tend to participate in mutual protein–protein interactions (PPIs) and are often functionally associated. Here, we investigated the relationship between disease‐associated proteins and
Externí odkaz:
https://doaj.org/article/0dc6277ed9ac46ef84d7c3d84a05f375