Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors.

Autor: Andrew A Sproul, Samson Jacob, Deborah Pre, Soong Ho Kim, Michael W Nestor, Miriam Navarro-Sobrino, Ismael Santa-Maria, Matthew Zimmer, Soline Aubry, John W Steele, David J Kahler, Alex Dranovsky, Ottavio Arancio, John F Crary, Sam Gandy, Scott A Noggle

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e84547 (2014)

Presenilin 1 (PSEN1) encodes the catalytic subunit of γ-secretase, and PSEN1 mutations are the most common cause of early onset familial Alzheimer's disease (FAD). In order to elucidate pathways downstream of PSEN1, we characterized neural progenito

Externí odkaz: https://doaj.org/article/044e69604c744103bad968cd9a9fb4bc

Design of cell-penetrating peptides

Autor: Gérard Chassaing, Sandrine Sagan, Baptiste Aussedat, Saskia A. Bode, Marion Thevenin, Chen-Yu Jiao, Soline Aubry, Solange Lavielle, Fabienne Burlina

Publikováno v: Collection Symposium Series.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04556986b641a39b451ef3b8d0e749d4
https://doi.org/10.1135/css201113004

Membrane interaction and perturbation mechanisms induced by two cationic cell penetrating peptides with distinct charge distribution

Autor: Isabel D. Alves, Sandrine Sagan, Nicole Goasdoué, Solange Lavielle, Gérard Chassaing, Soline Aubry, Isabelle Correia, Cécile Galanth

Publikováno v: BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2010, 1780 ((7-8)), pp.948-59. ⟨10.1016/j.bbagen.2008.04.004⟩
Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2008, 1780 (7-8), pp.948-59. ⟨10.1016/j.bbagen.2008.04.004⟩
Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2008, 1780 (7-8), pp.948-959. ⟨10.1016/j.bbagen.2008.04.004⟩
BBA-Biochimica et Biophysica Acta, 2010, 1780 ((7-8)), pp.948-59. ⟨10.1016/j.bbagen.2008.04.004⟩
Biochimica et Biophysica Acta (BBA)-General Subjects, 2008, 1780 (7-8), pp.948-959. ⟨10.1016/j.bbagen.2008.04.004⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2008, 1780 (7-8), pp.948-59. ⟨10.1016/j.bbagen.2008.04.004⟩

International audience; Independently from the cell penetrating peptide uptake mechanism (endocytic or not), the interaction of the peptide with the lipid bilayer remains a common issue that needs further investigation. The cell penetrating or antimi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0841a02313e558fca12f91b54a996e
https://hal.archives-ouvertes.fr/hal-00407766

[Tracking Trojan peptides in cells]

Autor: Sandrine, Sagan, Fabienne, Burlina, Diane, Delaroche, Baptiste, Aussedat, Soline, Aubry, Gérard, Bolbach, Solange, Lavielle, Gérard, Chassaing

Publikováno v: Journal de la Societe de biologie. 200(3)

Trojan peptides or cell-penetrating peptides (CPP) are natural or designed peptides identified as cellular membrane-crossing molecules, in particular through their potency to vehiculate various kinds of compounds to the cytoplasm and nucleus of livin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c19a535ebc42290b03b2f765b1c5b83d
https://pubmed.ncbi.nlm.nih.gov/17417135

Assembly and Interrogation of Alzheimer’s Disease Genetic Networks Reveal Novel Regulators of Progression

Autor: John F. Crary, Roger Lefort, William Shin, Soline Aubry, Yasir H. Qureshi, Andrea Califano, Michael L. Shelanski, Celine Lefebvre

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 3, p e0120352 (2015)

Alzheimer's disease (AD) is a complex multifactorial disorder with poorly characterized pathogenesis. Our understanding of this disease would thus benefit from an approach that addresses this complexity by elucidating the regulatory networks that are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863352c526af580b23db59665d28bbcc
https://doi.org/10.1371/journal.pone.0120352