Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Solida Long"'
Autor:
Mariana C. Almeida, Nikoletta Szemerédi, Fernando Durães, Solida Long, Diana I. S. P. Resende, Paulo Martins da Costa, Madalena Pinto, Gabriella Spengler, Emília Sousa
Publikováno v:
Antibiotics, Vol 12, Iss 5, p 922 (2023)
Drug resistance is rising to alarming levels, constituting one of the major threats to global health. The overexpression of efflux pumps and the formation of biofilms constitute two of the most common resistance mechanisms, favoring the virulence of
Externí odkaz:
https://doaj.org/article/887c16dec5c64af9894bd3da2b4296c3
Autor:
Sandra Barreiro, Bárbara Silva, Solida Long, Madalena Pinto, Fernando Remião, Emília Sousa, Renata Silva
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1456 (2022)
Neurodegenerative diseases (ND) share common molecular/cellular mechanisms that contribute to their progression and pathogenesis. In this sense, we are here proposing new neuroprotection strategies by using marine-derived compounds as fiscalins. This
Externí odkaz:
https://doaj.org/article/60dd8f1a00944955aa35df7932e379be
Autor:
Solida Long, Izadora L. Furlani, Juliana M. de Oliveira, Diana I. S. P. Resende, Artur M. S. Silva, Luís Gales, José A. Pereira, Anake Kijjoa, Quezia B. Cass, Regina V. Oliveira, Emília Sousa, Madalena M. M. Pinto
Publikováno v:
Molecules, Vol 26, Iss 16, p 5070 (2021)
In recent decades, fungi-derived naturally occurring quinazolines have emerged as potential drug candidates. Nevertheless, most studies are conducted for bioactivity assays, and little is known about their absorption, distribution, metabolism, and el
Externí odkaz:
https://doaj.org/article/c02d9b09174f4208890f6eba6f7a3406
Autor:
Solida Long, Joana B. Loureiro, Carla Carvalho, Luís Gales, Lucília Saraiva, Madalena M. M. Pinto, Ploenthip Puthongking, Emília Sousa
Publikováno v:
Molecules, Vol 26, Iss 6, p 1637 (2021)
The tumor suppressor p53 is inactivated by mutation in approximately 50% of human cancers. Small molecules that bind and stabilize those mutants may represent effective anticancer drugs. Herein, we report the tumor cell growth inhibitory activity of
Externí odkaz:
https://doaj.org/article/e4acd70a007b499faa2244492ea32ab3
Autor:
Solida Long, Diana I. S. P. Resende, Anake Kijjoa, Artur M. S. Silva, Ricardo Fernandes, Cristina P. R. Xavier, M. Helena Vasconcelos, Emília Sousa, Madalena M. M. Pinto
Publikováno v:
Molecules, Vol 24, Iss 3, p 534 (2019)
New quinazolinone derivatives of the marine-derived alkaloids fiscalin B (3) and fumiquinazoline G (1), with neuroprotective and antitumor effects, were synthesized. Eleven quinazolinone-containing indole alkaloids were synthesized, proceeding the an
Externí odkaz:
https://doaj.org/article/10fccd8bd1cc431f8e5636865fc77f2d
Autor:
Renata Silva, Fernando Remião, Sandra Barreiro, Barbara Silva, Solida Long, Madalena Pinto, Maria Emília Sousa
Publikováno v:
Pharmaceutics; Volume 14; Issue 7; Pages: 1456
Neurodegenerative diseases (ND) share common molecular/cellular mechanisms that contribute to their progression and pathogenesis. In this sense, we are here proposing new neuroprotection strategies by using marine-derived compounds as fiscalins. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a23c5e2bd1f3b25b27a2fa375860d3
https://pubmed.ncbi.nlm.nih.gov/35890350
https://pubmed.ncbi.nlm.nih.gov/35890350
Autor:
Andreia Palmeira, Joana Freitas-Silva, Fernando Remião, Madalena Pinto, Solida Long, Patrícia Pereira-Terra, Diana I. S. P. Resende, Sandra Barreiro, Renata Silva, Eugénia Pinto, Maria Elizabeth Tiritan, Emília Sousa, Paulo Martins da Costa, Anake Kijjoa, Artur M. S. Silva
Publikováno v:
RSC Advances. 10:31187-31204
Due to the emergence of multidrug-resistant pathogenic microorganisms, the search for novel antimicrobials is urgent. Inspired by marine alkaloids, a series of indolomethyl pyrazino [1,2-b]quinazoline-3,6-diones was prepared using a one-pot microwave
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a444629d5a3bbf8e650c059d7f50ee2
https://doi.org/10.1039/d0ra05319h
https://doi.org/10.1039/d0ra05319h
Autor:
Solida Long, Denise Duarte, Carla Carvalho, Rafael Oliveira, Nuno Santarém, Andreia Palmeira, Diana I. S. P. Resende, Artur M. S. Silva, Rui Moreira, Anake Kijjoa, Anabela Cordeiro da Silva, Fátima Nogueira, Emília Sousa, Madalena M. M. Pinto
The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsmedchemlett.1c00589. Malaria, leishmaniasis, and sleeping sickness are potentially fatal diseases that represent a real health risk for more than 3,5 billio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9641ad35d4fa95ee286cd2ad3f3c5c3b
https://hdl.handle.net/10362/134564
https://hdl.handle.net/10362/134564
Autor:
Solida Long, Diana I. S. P. Resende, Anake Kijjoa, Artur M. S. Silva, André Pina, Tamara Fernández-Marcelo, M. Helena Vasconcelos, Emília Sousa, Madalena M. M. Pinto
Publikováno v:
Marine Drugs, Vol 16, Iss 8, p 261 (2018)
Many fungal quinazolinone metabolites, which contain the methyl-indole pyrazino [1,2-b]quinazoline-3,6-dione core, have been found to possess promising antitumor activity. The purpose of this work was to synthesize the enantiomeric pairs of two membe
Externí odkaz:
https://doaj.org/article/fff3188f455242068df7dd5b511d8012
Autor:
Solida, Long, Denise, Duarte, Carla, Carvalho, Rafael, Oliveira, Nuno, Santarém, Andreia, Palmeira, Diana I S P, Resende, Artur M S, Silva, Rui, Moreira, Anake, Kijjoa, Anabela, Cordeiro da Silva, Fátima, Nogueira, Emília, Sousa, Madalena M M, Pinto
Publikováno v:
ACS Med Chem Lett
[Image: see text] Malaria, leishmaniasis, and sleeping sickness are potentially fatal diseases that represent a real health risk for more than 3,5 billion people. New antiparasitic compounds are urgent leading to a constant search for novel scaffolds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa6dc6914de4f80d5340195821a7154b
https://pubmed.ncbi.nlm.nih.gov/35178179
https://pubmed.ncbi.nlm.nih.gov/35178179