Zobrazeno 1 - 10
of 3 299
pro vyhledávání: '"Solid-phase peptide synthesis"'
Autor:
Giovanni Vivenzio, Maria Carmina Scala, Giulia Auriemma, Carla Sardo, Pietro Campiglia, Marina Sala
Publikováno v:
Green Chemistry Letters and Reviews, Vol 17, Iss 1 (2024)
Solid Phase Peptide Synthesis (SPPS) is the preferred technique for synthesizing bioactive peptides. However, traditional SPPS generates significant waste and employs hazardous solvents like DMF and DCM. The aim of this research is to investigate sol
Externí odkaz:
https://doaj.org/article/b215698705f24df3805aec89eb1865af
Autor:
Hlobisile Nzama, Srinivas Rao Manne, Oleg Marder, Gyorgy Orosz, Beatriz G. de la Torre, Fernando Albericio
Publikováno v:
Green Chemistry Letters and Reviews, Vol 17, Iss 1 (2024)
Although N-ethyl-N’-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) is a common reagent in peptide synthesis, it presents two drawbacks. First of all, it is in a tautomerism equilibrium with cyclic form that it is not productive. Secon
Externí odkaz:
https://doaj.org/article/adbd819b867e4545bd2fff0c77dbc9ea
Autor:
Marie Prochiner, Benedikt Judmann, Alina Ruder, Björn Wängler, Ralf Schirrmacher, Carmen Wängler
Publikováno v:
Pharmaceuticals, Vol 17, Iss 10, p 1280 (2024)
Background: Affibody molecules represent a class of highly specific binders of particular interest for the development of highly affine target-specific radiopharmaceuticals. Their chemical synthesis is, however, intricate due to their considerable le
Externí odkaz:
https://doaj.org/article/99280944783a41a89c6e96d3c0c160c9
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 17, Pp 1247-1274 (2023)
Sebastian Vaas,1 Markus O Zimmermann,1 Theresa Klett,1 Frank M Boeckler1,2 1Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, Laboratory for Molecular Design and Pharmaceutical Biophysics, Institute of Pharmaceutical Sci
Externí odkaz:
https://doaj.org/article/482bcab4572a4d03ae3cdcd2f5006481
Publikováno v:
SLAS Technology, Vol 28, Iss 2, Pp 89-97 (2023)
The development of peptide-based pharmaceutics is a hot topic in the pharmaceutical industry and in basic research. However, from the research and development perspective there is an unmet need for new, alternative, solid-phase peptide synthesizers t
Externí odkaz:
https://doaj.org/article/2e9a9c1ea30747f2ae680cf7ccb4efeb
Autor:
Dilyana Dimitrova, Veronica Nemska, Tsvetelina Foteva, Ivan Iliev, Nelly Georgieva, Dancho Danalev
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 716 (2024)
(1) Background: Antimicrobial resistance is growing at an extreme pace and has proven to be an urgent topic, for research into alternative treatments. Such a prospective possibility is hidden in antimicrobial peptides because of their low to no toxic
Externí odkaz:
https://doaj.org/article/e1bd56d786014457bbb4a744f631b3c0
Publikováno v:
Results in Chemistry, Vol 6, Iss , Pp 101076- (2023)
A method for the introduction of bifunctionalized 1,4,7,10-tetraazacyclododecane-N,N’,N’’,N’’’-tetraacetic acid (DOTA) into the bridging unit of peptide-based radiopharmaceuticals has been developed. The method is executed in the context
Externí odkaz:
https://doaj.org/article/14bbec5ebe624e79b8bdbc8d04dc33b5
Autor:
Bo Ma, Jinyuan Gong, Xin Li, Wenqiang Liu, Baoquan Chen, Zijian Lai, Shiying Shang, Yaohao Li, Jian Yin, Zhongping Tan
Publikováno v:
Results in Chemistry, Vol 6, Iss , Pp 101017- (2023)
Chemical synthesis has become an increasing popular approach for the production of proteins because of its flexibility and convenience in changing protein sequence and/or structure. However, at present, the efficiency of protein chemical synthesis is
Externí odkaz:
https://doaj.org/article/6d9e73af45ca47a6ad5037be19e87099
Publikováno v:
Shipin gongye ke-ji, Vol 43, Iss 23, Pp 26-34 (2022)
In this study, using angiotensin converting enzyme (ACE) inhibitory peptides PHP1 and PHP2 as the parent peptides, the hydrophobicity and electrical properties of target polypeptides were altered by substituting amino acid residues. In addition, the
Externí odkaz:
https://doaj.org/article/af58d89c0084465da158cdc5b078165b
Autor:
Sinazo Z.Z. Cobongela, Maya M. Makatini, Zikhona Njengele-Tetyana, Lucky M. Sikhwivhilu, Nicole R.S. Sibuyi
Publikováno v:
Arabian Journal of Chemistry, Vol 16, Iss 8, Pp 105000- (2023)
Acyldepsipeptides (ADEPs) are receiving more attention as prospective antimicrobial agents due to their unique mode of action and chemical properties. However, their therapeutic potential is limited by their poor pharmacokinetic properties. Chemical
Externí odkaz:
https://doaj.org/article/1537182a5ba14c83a1de6a96a5718598