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pro vyhledávání: '"Soledad Alzina"'
Autor:
Laura Vidal, Sonia Sentellas, Gema Tarrasón, Soledad Alzina, Silvia Gual, Bernat Vidal, Cristina Esteve, Irene Jover, Jacob González, Jorge De Alba, Montserrat Miralpeix, Raquel Horrillo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1217-1222
Synthesis and SAR of a series of 7-azaindoles as Orai channel inhibitors showing good potency inhibiting IL-2 production in Jurkat cells is described. Compound 14d displaying best pharmacokinetic properties was further characterized in a model of all