Heterogeneous stock rats: a model to study the genetics of despair-like behavior in adolescence

Autor: Holl, K, He, H, Wedemeyer, M, Clopton, L, Wert, S, Meckes, JK, Cheng, R, Kastner, A, Palmer, AA, Redei, EE, Solberg Woods, LC

Publikováno v: Holl, K; He, H; Wedemeyer, M; Clopton, L; Wert, S; Meckes, JK; et al.(2018). Heterogeneous stock rats: a model to study the genetics of despair-like behavior in adolescence. Genes, Brain and Behavior, 17(2), 139-148. doi: 10.1111/gbb.12410. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/61w4j51r
Genes, brain, and behavior, vol 17, iss 2

© 2017 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society Major depressive disorder (MDD) is a complex illness caused by both genetic and environmental factors. Antidepressant resistance also has a genetic component. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bd82a96d4874acefe8113982c03db70a
https://europepmc.org/articles/PMC5836722/

Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same construct.

Autor: de Guglielmo G; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Carrette L; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Kallupi M; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Brennan M; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Boomhower B; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Maturin L; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Conlisk D; Department of Neuroscience, The Scripps Research Institute, La Jolla, San Diego, United States., Sedighim S; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Tieu L; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Fannon MJ; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Martinez AR; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Velarde N; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Othman D; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Sichel B; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Ramborger J; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Lau J; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Kononoff J; Department of Neuroscience, The Scripps Research Institute, La Jolla, San Diego, United States., Kimbrough A; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Simpson S; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Smith LC; Department of Psychiatry, University of California, San Diego, La Jolla, United States.; Department of Neuroscience, The Scripps Research Institute, La Jolla, San Diego, United States., Shankar K; Department of Psychiatry, University of California, San Diego, La Jolla, United States.; Department of Neuroscience, The Scripps Research Institute, La Jolla, San Diego, United States., Bonnet-Zahedi S; Department of Psychiatry, University of California, San Diego, La Jolla, United States.; Institut de Neurosciences de la Timone, Aix-Marseille Université, Marseille, France., Sneddon EA; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Avelar A; Department of Psychiatry, University of California, San Diego, La Jolla, United States.; Department of Neuroscience, The Scripps Research Institute, La Jolla, San Diego, United States., Plasil SL; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Mosquera J; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Crook C; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Chun L; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Vang A; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Milan KK; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Schweitzer P; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Lin B; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Peng B; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Chitre AS; Department of Psychiatry, University of California, San Diego, La Jolla, United States., Polesskaya O; Department of Psychiatry, University of California, San Diego, La Jolla, United States.; Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States., Solberg Woods LC; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, United States., Palmer AA; Department of Psychiatry, University of California, San Diego, La Jolla, United States.; Institute for Genomic Medicine, University of California, San Diego, La Jolla, United States., George O; Department of Psychiatry, University of California, San Diego, La Jolla, United States.

Publikováno v: ELife [Elife] 2024 Nov 01; Vol. 12. Date of Electronic Publication: 2024 Nov 01.

Genome-wide association study of delay discounting in Heterogeneous Stock rats.

Autor: Lara MK; Department of Psychiatry, University of California San Diego, La Jolla, California, USA., Chitre AS; Department of Psychiatry, University of California San Diego, La Jolla, California, USA., Chen D; Department of Psychiatry, University of California San Diego, La Jolla, California, USA., Johnson BB; Department of Psychiatry, University of California San Diego, La Jolla, California, USA., Nguyen KM; Department of Psychiatry, University of California San Diego, La Jolla, California, USA., Cohen KA; Department of Psychiatry, University of California San Diego, La Jolla, California, USA., Muckadam SA; Department of Psychiatry, University of California San Diego, La Jolla, California, USA., Lin B; Department of Psychiatry, University of California San Diego, La Jolla, California, USA., Ziegler S; Department of Psychiatry, University of California San Diego, La Jolla, California, USA., Beeson A; Department of Internal Medicine, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA., Sanches TM; Department of Psychiatry, University of California San Diego, La Jolla, California, USA., Solberg Woods LC; Department of Internal Medicine, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA., Polesskaya O; Department of Psychiatry, University of California San Diego, La Jolla, California, USA., Palmer AA; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA., Mitchell SH; Department of Behavioral Neuroscience, Psychiatry, the Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, Oregon, USA.

Publikováno v: Genes, brain, and behavior [Genes Brain Behav] 2024 Aug; Vol. 23 (4), pp. e12909.

A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats.

Autor: de Jong TV; Department of Pharmacology, Addiction Science, and Toxicology, University of Tennessee Health Science Center, Memphis, TN, USA., Pan Y; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Rastas P; Institute of Biotechnology, University of Helsinki, Helsinki, Finland., Munro D; Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Department of Integrative Structural and Computational Biology, Scripps Research, San Diego, CA, USA., Tutaj M; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA; Rat Genome Database, Medical College of Wisconsin, Milwaukee, WI, USA., Akil H; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA., Benner C; Department of Medicine, University of California San Diego, San Diego, CA, USA., Chen D; Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Chitre AS; Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Chow W; Tree of Life, Wellcome Sanger Institute, Cambridge, UK., Colonna V; Institute of Genetics and Biophysics, National Research Council, Naples, Italy; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Dalgard CL; Department of Anatomy, Physiology & Genetics, The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Demos WM; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA; Rat Genome Database, Medical College of Wisconsin, Milwaukee, WI, USA., Doris PA; The Brown Foundation Institute of Molecular Medicine, Center for Human Genetics, University of Texas Health Science Center, Houston, TX, USA., Garrison E; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Geurts AM; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA., Gunturkun HM; Department of Pharmacology, Addiction Science, and Toxicology, University of Tennessee Health Science Center, Memphis, TN, USA., Guryev V; Genome Structure and Ageing, University of Groningen, UMC, Groningen, the Netherlands., Hourlier T; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus in Hinxton, Cambridgeshire, UK., Howe K; Tree of Life, Wellcome Sanger Institute, Cambridge, UK., Huang J; Department of Pharmacology, Addiction Science, and Toxicology, University of Tennessee Health Science Center, Memphis, TN, USA., Kalbfleisch T; Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Louisville, KY, USA., Kim P; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Li L; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA., Mahaffey S; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Martin FJ; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus in Hinxton, Cambridgeshire, UK., Mohammadi P; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA., Ozel AB; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Polesskaya O; Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Pravenec M; Institute of Physiology, Czech Academy of Sciences, Prague, Czechia., Prins P; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Sebat J; Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Smith JR; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA; Rat Genome Database, Medical College of Wisconsin, Milwaukee, WI, USA., Solberg Woods LC; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Tabakoff B; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Tracey A; Tree of Life, Wellcome Sanger Institute, Cambridge, UK., Uliano-Silva M; Tree of Life, Wellcome Sanger Institute, Cambridge, UK., Villani F; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Wang H; Department of Animal Sciences, Washington State University, Pullman, WA, USA., Sharp BM; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Telese F; Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Jiang Z; Department of Animal Sciences, Washington State University, Pullman, WA, USA., Saba L; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Wang X; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA., Murphy TD; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA., Palmer AA; Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Kwitek AE; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA; Rat Genome Database, Medical College of Wisconsin, Milwaukee, WI, USA., Dwinell MR; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA; Rat Genome Database, Medical College of Wisconsin, Milwaukee, WI, USA., Williams RW; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Li JZ; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA. Electronic address: junzli@med.umich.edu., Chen H; Department of Pharmacology, Addiction Science, and Toxicology, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address: hchen@uthsc.edu.

Publikováno v: Cell genomics [Cell Genom] 2024 Apr 10; Vol. 4 (4), pp. 100527. Date of Electronic Publication: 2024 Mar 26.

Reversal of biological age in multiple rat organs by young porcine plasma fraction.

Autor: Horvath S; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. shorvath@mednet.ucla.edu.; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA, USA. shorvath@mednet.ucla.edu.; Altos Labs, Cambridge, UK. shorvath@mednet.ucla.edu., Singh K; Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS University, Mumbai, India., Raj K; Altos Labs, Cambridge, UK., Khairnar SI; Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS University, Mumbai, India., Sanghavi A; Yuvan Research Inc., Mountain View, CA, USA., Shrivastava A; Yuvan Research Inc., Mountain View, CA, USA., Zoller JA; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA, USA., Li CZ; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA, USA., Herenu CB; Institute for Experimental Pharmacology of Cordoba (IFEC), School of Chemical Sciences, National University of Cordoba, Cordoba, Argentina., Canatelli-Mallat M; Biochemistry Research Institute of La Plata-Histology B, Pathology B, School of Medicine, University of La Plata, La Plata, Argentina., Lehmann M; Biochemistry Research Institute of La Plata-Histology B, Pathology B, School of Medicine, University of La Plata, La Plata, Argentina., Habazin S; Genos Glycoscience Research Laboratory, Zagreb, Croatia., Novokmet M; Genos Glycoscience Research Laboratory, Zagreb, Croatia., Vučković F; Genos Glycoscience Research Laboratory, Zagreb, Croatia., Solberg Woods LC; Wake Forest University School of Medicine, Medical Center Drive, Winston Salem, NC, USA., Martinez AG; Department of Pharmacology, Addiction Science and Toxicology, The University of Tennessee Health Science Center, Memphis, TN, USA., Wang T; Department of Pharmacology, Addiction Science and Toxicology, The University of Tennessee Health Science Center, Memphis, TN, USA., Chiavellini P; Biochemistry Research Institute of La Plata-Histology B, Pathology B, School of Medicine, University of La Plata, La Plata, Argentina., Levine AJ; Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA., Chen H; Department of Pharmacology, Addiction Science and Toxicology, The University of Tennessee Health Science Center, Memphis, TN, USA., Brooke RT; Epigenetic Clock Development Foundation, Torrance, CA, USA., Gordevicius J; Epigenetic Clock Development Foundation, Torrance, CA, USA., Lauc G; Genos Glycoscience Research Laboratory, Zagreb, Croatia.; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia., Goya RG; Biochemistry Research Institute of La Plata-Histology B, Pathology B, School of Medicine, University of La Plata, La Plata, Argentina., Katcher HL; Yuvan Research Inc., Mountain View, CA, USA. har.kat@yuvanresearch.com.

Publikováno v: GeroScience [Geroscience] 2024 Feb; Vol. 46 (1), pp. 367-394. Date of Electronic Publication: 2023 Oct 24.