Výsledky vyhledávání - "Solar Simulated Radiation"

Akademický článek

Melanin distribution in human epidermis affords localized protection against DNA photodamage and concurs with skin cancer incidence difference in extreme phototypes

Autor: Fajuyigbe, D., Lwin, S.M., Diffey, B.L., Baker, Richard, Tobin, Desmond J., Sarkany, R.P.E., Young, A.R.

Epidermal DNA damage, especially to the basal layer, is an established cause of keratinocyte cancers (KCs). Large differences in KC incidence (20- to 60-fold) between white and black populations are largely attributable to epidermal melanin photoprot

Externí odkaz: http://hdl.handle.net/10454/15611

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Akademický článek

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Dark cyclobutane pyrimidine dimers are formed in the epidermis of Fitzpatrick skin types I/II and VI in vivo after exposure to solar‐simulated radiation

Autor: Thierry Douki, Arjan van Dijk, Antony R. Young, Robert Sarkany, Damilola Fajuyigbe

Publikováno v: Pigment Cell & melanoma research
Pigment Cell & melanoma research, Blackwell Munksgaard, 2020, ⟨10.1111/pcmr.12956⟩
Pigment Cell & melanoma research, 2020, ⟨10.1111/pcmr.12956⟩

International audience; Introduction: Unlike "light" cylobutane pyrimidine dimers (CPD) formed during ultraviolet radiation (UVR) exposure, dark CPD (dCPD) are formed afterwards. Studies have attributed this to delayed melanin sensitization. There ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80848912fe1a60c8d86a69e2ac9f90d
https://doi.org/10.1111/pcmr.12956

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Remodelling of fibrillin-rich microfibrils by solar-simulated radiation: impact of skin ethnicity

Autor: Christopher E.M. Griffiths, Patrick Costello, Poonam Halai, Michael J. Sherratt, Rachel E.B. Watson, Mark Hann, A.K. Langton

Publikováno v: Photochemical & Photobiological Sciences. 19:1160-1167

Fibrillin-rich microfibrils (FRMs) constitute integral components of the dermal elastic fibre network with a distinctive ultrastructural 'beads-on-a-string' appearance that can be visualised using atomic force microscopy and characterised by measurem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f9134a6d827077774547863ea646567
https://doi.org/10.1039/d0pp00188k

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Proteomic fingerprints of damage in extracellular matrix assemblies

Autor: Matiss Ozols, Rachel E.B. Watson, Ronan O’Cualain, April Foster, Suzanne M. Pilkington, Christopher E.M. Griffiths, David Knight, Alexander Eckersley, Emma-Jayne Keevill, Michael J. Sherratt

Publikováno v: Matrix Biology Plus, Vol 5, Iss, Pp-(2020)
Eckersley, A, Ozols, M, O'Cualain, R, Keevill, E-J, Foster, A R, Pilkington, S, Knight, D, Griffiths, CEM, Watson, R & Sherratt, M 2020, ' Proteomic fingerprints of damage in extracellular matrix assemblies ', Matrix Biology Plus . https://doi.org/10.1016/j.mbplus.2020.100027
Matrix Biology Plus

In contrast to the dynamic intracellular environment, structural extracellular matrix (ECM) proteins with half-lives measured in decades, are susceptible to accumulating damage. Whilst conventional approaches such as histology, immunohistochemistry a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d03d583e7557fcc24af267784aa789
http://www.sciencedirect.com/science/article/pii/S2590028520300089

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Oral green tea catechins do not provide photoprotection from direct DNA damage induced by higher dose solar simulated radiation: A randomized controlled trial

Autor: Tristan P. Dew, Sarah Mason, Kayleigh A. Clarke, Rachel E.B. Watson, Gary Williamson, Mark D. Farrar, Raqib Huq, Lesley E. Rhodes, Anna Nicolaou

Publikováno v: Farrar, M, Huq, R, Mason, S, Nicolaou, A, Clarke, K A, Dew, T P, Williamson, G, Watson, R & Rhodes, L 2018, ' Oral green tea catechins do not provide photoprotection from direct DNA damage induced by higher dose solar simulated radiation : A randomized controlled trial ', J Am Acad Dermatol, vol. 78, no. 2, pp. 414-416 . https://doi.org/10.1016/j.jaad.2017.08.021
Journal of the American Academy of Dermatology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b9b1088b10e1c7a64ff6ddbb665955
https://doi.org/10.1016/j.jaad.2017.08.021

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A potential role for endogenous proteins as sacrificial sunscreens and antioxidants in human tissues

Autor: Rachel E.B. Watson, Sarah A. Hibbert, Christopher E.M. Griffiths, Neil K. Gibbs, Anthony S. Weiss, Patrick Costello, Clair Baldock, Michael J. Sherratt

Publikováno v: Redox Biology, Vol 5, Iss, Pp 101-113 (2015)
Redox Biology

Excessive ultraviolet radiation (UVR) exposure of the skin is associated with adverse clinical outcomes. Although both exogenous sunscreens and endogenous tissue components (including melanins and tryptophan-derived compounds) reduce UVR penetration,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e38bb07c886a62426eaebc63968d8c
http://www.sciencedirect.com/science/article/pii/S2213231715000348

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Akademický článek

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Complexity of matrix phenotypes

Autor: Renato V. Iozzo, Achilleas D. Theocharis, Thomas Neill, Nikos K. Karamanos

Publikováno v: Matrix Biology Plus, Vol 6, Iss, Pp 100038-(2020)
Matrix Biology Plus

The extracellular matrix is engaged in an ever-evolving and elegant ballet of dynamic reciprocity that directly and bi-directionally regulates cell behavior. Homeostatic and pathophysiological changes in cell-matrix signaling cascades manifest as com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0706f5167c8f3bf2dfb334f7e3546a
https://doi.org/10.1016/j.mbplus.2020.100038

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