Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Solange Le Blanc"'
Autor:
Ilaria Guccini, Guanghui Tang, Trang Thuy To, Laura Di Rito, Solange Le Blanc, Oliver Strobel, Mariantonietta D’Ambrosio, Emiliano Pasquini, Marco Bolis, Pamuditha Silva, Hasan Ali Kabakci, Svenja Godbersen, Andrea Alimonti, Gerald Schwank, Markus Stoffel
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107368- (2023)
Summary: Although dietary fructose is associated with an elevated risk for pancreatic cancer, the underlying mechanisms remain elusive. Here, we report that ketohexokinase (KHK), the rate-limiting enzyme of fructose metabolism, is a driver of PDAC de
Externí odkaz:
https://doaj.org/article/92e4cfa9282e4da99d2e1ee03163bd9e
Autor:
Sebastian Schuth, Solange Le Blanc, Teresa G. Krieger, Julia Jabs, Miriam Schenk, Nathalia A. Giese, Markus W. Büchler, Roland Eils, Christian Conrad, Oliver Strobel
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-14 (2022)
Abstract Background Cancer-associated fibroblasts (CAFs) are considered to play a fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and chemoresistance. Patient-derived organoids have demonstrated great potential as tumor avatar
Externí odkaz:
https://doaj.org/article/67e84cf093684d099e7a2f8d345931a2
Autor:
Teresa G. Krieger, Solange Le Blanc, Julia Jabs, Foo Wei Ten, Naveed Ishaque, Katharina Jechow, Olivia Debnath, Carl-Stephan Leonhardt, Anamika Giri, Roland Eils, Oliver Strobel, Christian Conrad
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Pancreatic tumors are frequently divided into basal and classical subtypes. Here, the authors use single cell sequencing to investigate organoids derived from pancreatic cancer tissue and find a hierarchy of distinct cell states, and classical and ba
Externí odkaz:
https://doaj.org/article/f77b80eb08eb4c0a93db5169bb083e64
Autor:
Michael Volkmar, Kazufumi Honda, Matthias M. Gaida, Thilo Hackert, Shutaro Hori, Frank Bergmann, Solange Le Blanc, Klaus Felix, Oliver Strobel, Xiaojun Xu, Simon Schimmack, Nami Miura
Publikováno v:
Journal of Cancer
Introduction: For pathological diagnosis of pancreatic neuroendocrine neoplasms (pNENs) the routinely used immunohistochemical markers are chromogranin A (CgA) and synaptophysin (Syn). Their ability as prognostic markers is not well established. A sp
Autor:
Meike, Simann, Solange, Le Blanc, Verena, Schneider, Viola, Zehe, Martin, Lüdemann, Norbert, Schütze, Franz, Jakob, Tatjana, Schilling
Publikováno v:
Journal of cellular biochemistry. 118(2)
Controlling the adipo-osteogenic lineage decision of trabecular human bone marrow stromal cells (hBMSCs) in favor of osteogenesis represents a promising approach for osteoporosis therapy and prevention. Previously, Fibroblast Growth Factor 1 (FGF1) a
Publikováno v:
Biological Trace Element Research. 150:496-501
Iron homeostasis is controlled by hepcidin (Hpc) as well as other ways. Hpc expression is regulated by iron (Fe) storage and by inflammation, but the joint effect of both stimuli remains unclear. We studied the modulatory role of inflammatory agents
Publikováno v:
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Heme-Fe is an important source of dietary iron in humans; however, the mechanism for heme-Fe uptake by enterocytes is poorly understood. Heme carrier protein 1 (HCP1) was originally identified as mediating heme-Fe transport although it later emerged
Epithelial-specific E3 ligase CBLc regulates differentiation and motility of pancreatic cancer cells
Autor:
Rienk Offringa, Nathalia A. Giese, Thilo Hackert, Solange Le Blanc, Thomas Hank, Miriam Schenk, Oliver Strobel, Michael Volkmar, Klaus Felix, Kai Hu
Publikováno v:
Pancreatology. 17:S32-S33
Publikováno v:
Experimental cell research. 338(2)
Multipotent human bone marrow stromal cells (hBMSCs) are the common progenitors of osteoblasts and adipocytes. A shift in hBMSC differentiation in favor of adipogenesis may contribute to the bone loss and marrow fat accumulation observed in aging and
Autor:
Franz Jakob, Tatjana Schilling, Julia Dotterweich, Verena Schneider, Norbert Schütze, Solange Le Blanc, Viola Zehe, Meike Simann, Melanie Krug
Publikováno v:
Bone. 78
Heparins are broadly used for the prevention and treatment of thrombosis and embolism. Yet, osteoporosis is considered to be a severe side effect in up to one third of all patients on long-term treatment. However, the mechanisms underlying this clini