Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Solange Gouin D'ambrieres"'
Autor:
Véronique Loyau, Alain Bonnefoy, Solange Gouin D'ambrieres, A Dussarat, Nicole Tessot, C. Fromentin, Sylvette Lachaud, Patrick Laurin, Jean-Michel Auger, Yannick Benedetti, Francois Bretin, J. F. Chantot, C. Agouridas, A. Denis, Le Martret Odile
Publikováno v:
Journal of Medicinal Chemistry. 41:4080-4100
In the search for new antibiotics active against macrolide-resistant pneumococci and Haemophilus influenzae, we synthesized a new class of 3-oxo-6-O-methylerythromycin derivatives, so-called "ketolides". A keto function was introduced in position 3 a
Publikováno v:
The Journal of Antibiotics. 44:313-330
The discovery of roxithromycin is the result of a rational and scientific process, based on the fact that at least one reason for erythromycin A's resorption variability after oral administration was its instability in the gastric juice. This instabi