The GnRH receptor and the response of gonadotrope cells to GnRH pulse frequency code. A story of an atypical adaptation of cell function relying on a lack of receptor homologous desensitization.

Autor: Christian Bleux, Violaine Simon, Jean-NoĂŤl Laverriere, Ghislaine Garrel, Raymond Counis, Solange Magre, JoĂŤlle Cohen-Tannoudji

Publikováno v: Folia Histochemica et Cytobiologica, Vol 47, Iss 5, Pp 81-87 (2010)

Brain control of the reproductive system is mediated through hypothalamic gonadotropin-releasing hormone (GnRH) which activates specific receptors (GnRHR) present at the surface of the pituitary gonadotropes to trigger secretion of the two gonadotrop

Externí odkaz: https://doaj.org/article/16476c15cb854fd8a888f59d71b021c6

Age-dependent vulnerability of the ovary to AhR-mediated TCDD action before puberty: Evidence from mouse models

Autor: Marie M Devillers, Florence Petit, Solange Magre, Charlotte M. François, Xavier Coumoul, Ludmila Juricek, Celine J. Guigon, Frank Giton, Joëlle Cohen-Tannoudji

Publikováno v: Chemosphere
Chemosphere, Elsevier, 2020, 258, ⟨10.1016/j.chemosphere.2020.127361⟩
Chemosphere, 2020, 258, ⟨10.1016/j.chemosphere.2020.127361⟩

International audience; In female mammals, puberty and fertility are regulated by the synthesis of estradiol (E2) by the ovaries at the infantile stage and at the approach of puberty, a process which may be affected by endocrine disrupting chemicals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e35be83ad82c8f80ea9de8c396984b
https://hal-cnrs.archives-ouvertes.fr/hal-03300411

A novel action of follicle-stimulating hormone in the ovary promotes estradiol production without inducing excessive follicular growth before puberty

Autor: Charlotte M. François, Florence Petit, Frank Giton, Alain Gougeon, Célia Ravel, Solange Magre, Joëlle Cohen-Tannoudji, Céline J. Guigon

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.46222. ⟨10.1038/srep46222⟩
Scientific Reports, 2017, 7 (1), pp.46222. ⟨10.1038/srep46222⟩

International audience; In cyclic females, FSH stimulates ovarian estradiol (E2) production and follicular growth up to the terminal stage. A transient elevation in circulating FSH and E2 levels occurs shortly after birth. But what could be the actio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f3eed8d4527bf1f0dc574e3745432c64
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01516023

What is the role of PACAP in gonadotrope function?

Autor: Solange Magre, Sigolène Larivière, Jean-Noël Laverrière, Christian Bleux, Joëlle Cohen-Tannoudji, Ghislaine Garrel-Lazayres, Raymond Counis

Publikováno v: Peptides. 28:1797-1804

Strong evidence in favor of a direct action of hypothalamic PACAP at the pituitary to modulate gonadotrope function has been acquired mainly by in vitro studies using cultured pituitary cells or gonadotrope cell lines. In particular, PACAP has been s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ab1eca187f2162ffa5bf476c5d625a
https://doi.org/10.1016/j.peptides.2007.05.011

Follicular Cells Acquire Sertoli Cell Characteristics after Oocyte Loss

Autor: Solange Magre, Maguelone G. Forest, Noëlline Coudouel, Séverine Mazaud-Guittot, Celine J. Guigon

Publikováno v: Endocrinology. 146:2992-3004

Although it has been suggested that in mammals the loss of female germ cells may induce the masculinization of the ovarian compartment, there has been as yet no conclusive demonstration. To directly address that question, the present study has been d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9bbff66cd7242654aeb392d93fbcf04
https://doi.org/10.1210/en.2005-0045