Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Sol Misener"'
Autor:
Benjamin R. Thomson, Pan Liu, Tuncer Onay, Jing Du, Stuart W. Tompson, Sol Misener, Raj R. Purohit, Terri L. Young, Jing Jin, Susan E. Quaggin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Primary congenital glaucoma (PCG) is characterised by increased intraocular pressure, and variants in ANGPT1, or SVEP1 have been identified as risk alleles. Here, the authors show that deletion of these genes induces glaucoma in mice, and that activa
Externí odkaz:
https://doaj.org/article/e73581bed66f4521bb3bfb4be3144e09
Autor:
Rajesh Gupta, Lijun Liu, Xiaolu Zhang, Xiaoming Fan, Prasanna Krishnamurthy, Suresh Verma, Jörn Tongers, Sol Misener, Nikita Ashcherkin, Hongliu Sun, Jiang Tian, Raj Kishore
Publikováno v:
JCI Insight, Vol 5, Iss 17 (2020)
Diabetes is a risk factor for myocardial infarction, and outcomes after myocardial infarction are worse among diabetics compared with nondiabetics. Diabetes is associated with impaired Heme clearance. Here, we determined whether heme toxicity and imp
Externí odkaz:
https://doaj.org/article/7b37eb7321e9490b9d8a744d14d4dfbc
Autor:
Jennifer Krcmery, Rajesh Gupta, Rudyard W Sadleir, Molly J Ahrens, Sol Misener, Christine Kamide, Philip Fitchev, Douglas W Losordo, Susan E Crawford, Hans-Georg Simon
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80809 (2013)
The actin-associated protein Pdlim7 is essential for heart and fin development in zebrafish; however, the expression and function of this PDZ-LIM family member in the mammal has remained unclear. Here, we show that Pdlim7 predominantly localizes to a
Externí odkaz:
https://doaj.org/article/34ceea1eba494ea294f5d1f31cb4710e
Autor:
Xiaoming Fan, Suresh K Verma, Hongliu Sun, Lijun Liu, Xiaolu Zhang, Jörn Tongers, Rajesh Gupta, Prasanna Krishnamurthy, Raj Kishore, Jiang Tian, Sol Misener, Nikita Ashcherkin
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 17 (2020)
JCI Insight, Vol 5, Iss 17 (2020)
Diabetes is a risk factor for myocardial infarction, and outcomes after myocardial infarction are worse among diabetics compared with nondiabetics. Diabetes is associated with impaired Heme clearance. Here, we determined whether heme toxicity and imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb01355dc3474bf2472525cdf95fd21
http://europepmc.org/articles/PMC7526458
http://europepmc.org/articles/PMC7526458
Autor:
Jing Jin, Susan E. Quaggin, Terri L. Young, Tuncer Onay, Jing Du, Stuart W. Tompson, Sol Misener, Raj R. Purohit, Pan Liu, Benjamin R. Thomson
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Primary congenital glaucoma (PCG) is a severe disease characterized by developmental defects in the trabecular meshwork (TM) and Schlemm’s canal (SC), comprising the conventional aqueous humor outflow pathway of the eye. Recently, heterozygous loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8f1715e3d62bb02696f07c2dab0ace
https://pubmed.ncbi.nlm.nih.gov/34663817
https://pubmed.ncbi.nlm.nih.gov/34663817
Autor:
Daniele Procissi, Michael Markl, James C. Carr, Nicola Bertolino, Jeremy D. Collins, Frederick H. Epstein, Nivedita K. Naresh, Cynthia Yang, Alexander Ruh, Sol Misener, Zhouli Zhang, Bradley A. Allen
Publikováno v:
NMR in Biomedicine. 33
Background Doxorubicin and doxorubicin-trastuzumab combination chemotherapy have been associated with cardiotoxicity that eventually leads to heart failure and may limit dose-effective cancer treatment. Current diagnostic strategies rely on decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8241ee39d241f2f81bf75def800af5
https://doi.org/10.1002/nbm.4327
https://doi.org/10.1002/nbm.4327
Autor:
Zhuoli Zhang, James C. Carr, Daniele Procissi, Sol Misener, Nivedita K. Naresh, Bradley D. Allen
Publikováno v:
Cardiovascular Toxicology. 19:482-484
An increasing volume of pre-clinical and clinical-translational research is attempting to identify novel biomarkers for improved diagnosis and risk-stratification of chemotherapy-induced cardiotoxicity. Most published animal models have employed week
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fdea40e9dd56ca6a29f567dba66e27f
https://doi.org/10.1007/s12012-019-09521-0
https://doi.org/10.1007/s12012-019-09521-0
Autor:
Sol Misener, C. Shad Thaxton, Kaylin M. McMahon, Richard Longnecker, Osman Cen, Tim Taxter, Leo I. Gordon, Jonathan S. Rink, Amir Behdad, Shuo Yang
Publikováno v:
Molecular Pharmaceutics. 14:4042-4051
Cancer cells have altered metabolism and, in some cases, an increased demand for cholesterol. It is important to identify novel, rational treatments based on biology, and cellular cholesterol metabolism as a potential target for cancer is an innovati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e730664350da5df12d39da24348460
https://doi.org/10.1021/acs.molpharmaceut.7b00710
https://doi.org/10.1021/acs.molpharmaceut.7b00710
Autor:
Sol Misener, Yaxuan Liang, Christine Kamide, Prabhu Mathiyalagan, David Kim, Tina Thorne, Douglas W. Losordo, Ekaterina Klyachko, Susmita Sahoo, Roger J. Hajjar
Publikováno v:
Circulation Research. 120:1466-1476
Rationale: Paracrine secretions seem to mediate therapeutic effects of human CD34 + stem cells locally transplanted in patients with myocardial and critical limb ischemia and in animal models. Earlier, we had discovered that paracrine secretion from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c264b7fc0de6a20fd617f33c2d96df15
https://doi.org/10.1161/circresaha.116.310557
https://doi.org/10.1161/circresaha.116.310557
Autor:
Jiao-Jing Wang, Sol Misener, Wangqiang Sun, Melina R. Kibbe, Vinayak P. Dravid, Jonathan S. Rink, Zheng Jenny Zhang, Subbu S. Venkatraman, C. Shad Thaxton
Publikováno v:
ACS Appl Mater Interfaces
Disorders of blood vessels cause a range of severe health problems. As a powerful vasodilator and cellular second messenger, nitric oxide (NO) is known to have beneficial vascular functions. However, NO typically has a short half-life and is not spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8123e5cc7b8d06c453fc9b0bd8cf4d
https://pubmed.ncbi.nlm.nih.gov/29385802
https://pubmed.ncbi.nlm.nih.gov/29385802