Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sol M. Reyna"'
Autor:
Matteo D'Antonio, Grace Woodruff, Jason L. Nathanson, Agnieszka D'Antonio-Chronowska, Angelo Arias, Hiroko Matsui, Roy Williams, Cheryl Herrera, Sol M. Reyna, Gene W. Yeo, Lawrence S.B. Goldstein, Athanasia D. Panopoulos, Kelly A. Frazer
Publikováno v:
Stem Cell Reports, Vol 8, Iss 4, Pp 1101-1111 (2017)
Summary: Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) offers the possibility of studying the molecular mechanisms underlying human diseases in cell types difficult to extract from living patients, such as neurons and cardiomy
Externí odkaz:
https://doaj.org/article/d69ba0728ffa406fb5c715d23e40fe06
Autor:
Grace Woodruff, Sol M. Reyna, Mariah Dunlap, Rik Van Der Kant, Julia A. Callender, Jessica E. Young, Elizabeth A. Roberts, Lawrence S.B. Goldstein
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 759-773 (2016)
We investigated early phenotypes caused by familial Alzheimer’s disease (fAD) mutations in isogenic human iPSC-derived neurons. Analysis of neurons carrying fAD PS1 or APP mutations introduced using genome editing technology at the endogenous loci
Externí odkaz:
https://doaj.org/article/abdcdd1273584ec69a3390b5c16d4b3b
Autor:
April M Weissmiller, Orlangie Natera-Naranjo, Sol M Reyna, Matthew L Pearn, Xiaobei Zhao, Phuong Nguyen, Soan Cheng, Lawrence S B Goldstein, Rudolph E Tanzi, Steven L Wagner, William C Mobley, Chengbiao Wu
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118379 (2015)
Clues to Alzheimer disease (AD) pathogenesis come from a variety of different sources including studies of clinical and neuropathological features, biomarkers, genomics and animal and cellular models. An important role for amyloid precursor protein (
Externí odkaz:
https://doaj.org/article/67d94cb4c74847f09dd63eb7f1a20f27
Autor:
Elizabeth A. Roberts, Rodrigo S. Chaves, Sol M. Reyna, Vanessa F. Langness, Lauren K. Fong, Grace Woodruff, Lawrence S.B. Goldstein, Jessica E. Young, Max M. Yang
Publikováno v:
Journal of Biological Chemistry. 293:11341-11357
Mounting evidence suggests that alterations in cholesterol homeostasis are involved in Alzheimer's disease (AD) pathogenesis. Amyloid precursor protein (APP) or multiple fragments generated by proteolytic processing of APP have previously been implic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdedfda66154cfcf5cafcd50829f33bc
https://doi.org/10.1074/jbc.ra117.000441
https://doi.org/10.1074/jbc.ra117.000441
Autor:
Angelo Arias, Agnieszka D'Antonio-Chronowska, Cheryl Herrera, Jason L. Nathanson, Hiroko Matsui, Grace Woodruff, Matteo D’Antonio, Kelly A. Frazer, Lawrence S.B. Goldstein, Athanasia D. Panopoulos, Gene W. Yeo, Sol M. Reyna, Roy Williams
Publikováno v:
Stem cell reports, vol 8, iss 4
Stem Cell Reports, Vol 8, Iss 4, Pp 1101-1111 (2017)
Stem Cell Reports
Stem Cell Reports, Vol 8, Iss 4, Pp 1101-1111 (2017)
Stem Cell Reports
Summary Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) offers the possibility of studying the molecular mechanisms underlying human diseases in cell types difficult to extract from living patients, such as neurons and cardiomyo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6434726e12de09b3097b00815783d7b
https://doi.org/10.1016/j.stemcr.2017.03.011
https://doi.org/10.1016/j.stemcr.2017.03.011
Publikováno v:
Neurotherapeutics
Our understanding of Alzheimer’s disease (AD) is still incomplete and, as a result, we lack effective therapies. Reprogramming to generate human-induced pluripotent stem cells provides a new approach to the generation of human neurons that carry th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb21d2ac348d7f950ecd7c3573ac63c2
http://europepmc.org/articles/PMC4322074
http://europepmc.org/articles/PMC4322074
Autor:
Elizabeth A. Roberts, Jessica E. Young, Mariah Dunlap, Lawrence S.B. Goldstein, Sol M. Reyna, Rik van der Kant, Grace Woodruff, Julia A. Callender
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 759-773 (2016)
We investigated early phenotypes caused by familial Alzheimer’s Disease (fAD) mutations in isogenic human iPSC-derived neurons. Analysis of neurons carrying fAD PS1 or APP mutations introduced using genome editing technology at the endogenous loci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895ced638bc54630b5f43dd30c9d963d
https://europepmc.org/articles/PMC5796664/
https://europepmc.org/articles/PMC5796664/
Autor:
Sol M. Reyna, Francesca S. Boscolo, Louise C. Laurent, Anne M. Remes, Sebastiaan van Gorp, Edward H. Koo, Shauna H. Yuan, Lawrence S.B. Goldstein, Michael P. Hefferan, Fred H. Gage, Yangling Mu, Kristopher L. Nazor, Christian T. Carson, Cheryl Herrera, Martin Marsala, Mason A. Israel, Cedric Bardy
Publikováno v:
Nature, vol 482, iss 7384
Nature
Nature, 482(7384), 216-U107. Nature Publishing Group
Nature
Nature, 482(7384), 216-U107. Nature Publishing Group
Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease. It may be possible to overcome these challenges by reprogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a3617eda8a5a98af794ec45819b01e
https://cris.maastrichtuniversity.nl/en/publications/e4430046-ba7d-4be8-8f05-4f841ba7f10a
https://cris.maastrichtuniversity.nl/en/publications/e4430046-ba7d-4be8-8f05-4f841ba7f10a
Publikováno v:
Molecular biology of the cell, vol 26, iss 2
Molecular Biology of the Cell
Molecular Biology of the Cell
In mouse and human neurons, axonally secreted amyloid precursor protein (APP) fragments are processed in the cell body before being sorted into the axon in a process that requires endocytosis for the processing, but not axonal delivery, of APP.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd3f366378771ec04d3829ec6c5b69c
https://escholarship.org/uc/item/1jm0923r
https://escholarship.org/uc/item/1jm0923r
Autor:
William C. Mobley, April M. Weissmiller, Soan Cheng, Lawrence S.B. Goldstein, Xiaobei Zhao, Phuong Nguyen, Rudolph E. Tanzi, Matthew L. Pearn, Steven L. Wagner, Orlangie Natera-Naranjo, Sol M. Reyna, Chengbiao Wu
Publikováno v:
PLoS ONE
PloS one, vol 10, iss 2
PLoS ONE, Vol 10, Iss 2, p e0118379 (2015)
PloS one, vol 10, iss 2
PLoS ONE, Vol 10, Iss 2, p e0118379 (2015)
Clues to Alzheimer disease (AD) pathogenesis come from a variety of different sources including studies of clinical and neuropathological features, biomarkers, genomics and animal and cellular models. An important role for amyloid precursor protein (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26d80aa35cc36ade013d965cbb84b66
https://pubmed.ncbi.nlm.nih.gov/25710492
https://pubmed.ncbi.nlm.nih.gov/25710492