Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Sol J. Daum"'
Autor:
Malcolm R. Bell, Eissenstat Ma, E. J. Alexander, Olefirowicz Em, James H. Ackerman, Gruett, Thomas E. D'Ambra, Kumar, Sol J. Daum, Estep Kg
Publikováno v:
Journal of Medicinal Chemistry. 38:3094-3105
Aminoalkylindoles (AAIs) are a novel series of cannabinoid receptor ligands. In this report we disclose the structural features of AAIs which are important for binding to this receptor as measured by inhibition of binding of [ 3 H]Win 55212-2 (5). Fu
Autor:
David M. Sedlock, George Y. Lesher, Manohar Saindane, Sol J. Daum, Philip M. Carabateas, James B. Rake, Dorff Peter H, Michael Reuman, Robert B. Perni, S. A. Coughlin, Patrick O. Pennock, Mark P. Wentland, Baldev Singh, Monte D. Gruett
Publikováno v:
Journal of Medicinal Chemistry. 38:2531-2540
The palladium-catalyzed coupling of 3- and 4-(trialkylstannyl)pyridines with 7-bromo or 7-chloro 1-substituted 1,4-dihydro-4-oxo-3-quinolinecarboxylates has provided access to the corresponding 1-substituted 1,4-dihydro-4-oxo-7-pyridinyl-3-quinolinec
Autor:
J. L. Jun. Herrmann, Sol J. Daum, Margaret M. Wagner, G. M. Pilling, Robert G. Christiansen, Michael E. Krolski, M. A. Alexander, James H. Ackerman, Virendra Kumar, Malcolm R. Bell, Richard C. Winneker
Publikováno v:
ChemInform. 22
Autor:
E. R. Bacon, Sol J. Daum
Publikováno v:
ChemInform. 23
Autor:
Monte D. Gruett, Mark P. Wentland, Michael Reuman, Philip M. Carabateas, Robert B. Perni, Patrick O. Pennock, S. A. Coughlin, Manohar Saindane, David M. Sedlock, James B. Rake, Dorff Peter H, George Y. Lesher, Sol J. Daum, Baldev Singh
Publikováno v:
ChemInform. 26
The palladium-catalyzed coupling of 3- and 4-(trialkylstannyl)pyridines with 7-bromo or 7-chloro 1-substituted 1,4-dihydro-4-oxo-3-quinolinecarboxylates has provided access to the corresponding 1-substituted 1,4-dihydro-4-oxo-7-pyridinyl-3-quinolinec
Autor:
Michael A. Alexander, Virendra Kumar, Richard C. Winneker, Margaret M. Wagner, Robert G. Christiansen, John L. Herrmann, Malcolm R. Bell, Carry M. Pilling, Michael E. Krolski, Sol J. Daum, James H. Ackerman
Publikováno v:
Tetrahedron. 47:5099-5110
Syntheses of the unsubstituted steroidal [3,2-b]furan ( 3a ), thiophene ( 3b ) and [2,3-b]furan ( 24 ) are described. Lithiation of the THP ethers 18a and 18b followed by the reaction with methyl disulfide and deprotection gave the 5′-methylsulfide
Autor:
Sol J. Daum, E. R. Bacon
Publikováno v:
Journal of Heterocyclic Chemistry. 28:1953-1955
7-Ethyl-4,7-dihydro-4-oxo-2-(4-pyridinyl)thieno[2,3-b]pyridine-5-carboxylic acid (4), an analog of nalidixic acid, was synthesized in seven steps starting from commercially available 4-methylpyridine. Bacterial susceptibility to compound 4 was tested
Autor:
David Rosi, Wetzel, Dennis J. Hlasta, Sol J. Daum, John L. Herrmann, Malcolm R. Bell, Kumar, Thomas E. D'Ambra, Eissenstat Ma, Philion Re
Publikováno v:
Journal of medicinal chemistry. 34(3)
The (aminoalkyl)indole (AAI) derivative pravadoline (1a) inhibited prostaglandin (PG) synthesis in mouse brain microsomes in vitro and ex vivo and exhibited antinociceptive activity in several rodent assays. In vitro structure-activity relationship s
Publikováno v:
ChemInform. 21
The kinetically-controlled S-benzoylation of secondary thioformamides in the presence of triethylamine at low temperature provided S-benzoylthioimidates 6 . Without isolation, these unstable intermediates were utilized in the ketene-imine cycloadditi
Publikováno v:
Journal of Medicinal Chemistry. 21:1235-1242
Tropanes 4 bearing an exo aromatic group on carbon-2, an endo-carbomethoxy group on carbon-3, and either a methyl group or a hydrogen on the nitrogen were found to be narcotic antagonists which were devoid of demonstrable analgesic activity. The acti