Poly(2-oxazoline) nanoparticle delivery enhances the therapeutic potential of vismodegib for medulloblastoma by improving CNS pharmacokinetics and reducing systemic toxicity.

Autor: Hwang D; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, USA., Dismuke T; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA., Tikunov A; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA., Rosen EP; Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States., Kagel JR; Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States., Ramsey JD; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, USA., Lim C; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, USA., Zamboni W; Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States., Kabanov AV; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, USA; Laboratory of Chemical Design of Bionanomaterials, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russia., Gershon TR; Department of Neurology, UNC School of Medicine, University of North Carolina, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC, USA. Electronic address: gershont@neurology.unc.edu., Sokolsky-Papkov PhD M; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, USA. Electronic address: msokolsk@email.unc.edu.

Publikováno v: Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2021 Feb; Vol. 32, pp. 102345. Date of Electronic Publication: 2020 Nov 28.