Structural basis of RNA polymerase inhibition by viral and host factors

Autor: Simona Pilotto, Thomas Fouqueau, Natalya Lukoyanova, Carol Sheppard, Soizick Lucas-Staat, Luis Miguel Díaz-Santín, Dorota Matelska, David Prangishvili, Alan C. M. Cheung, Finn Werner

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Understanding the structural basis for the inhibition of archaeal eukaryotic-like RNA polymerases (RNAPs) during virus infection is of interest for drug design. Here, the authors present the cryo-EM structures of apo Sulfolobus acidocaldarius RNAP an

Externí odkaz: https://doaj.org/article/3d39de805d944392bdd55093bfcb0759

Model for a novel membrane envelope in a filamentous hyperthermophilic virus

Autor: Peter Kasson, Frank DiMaio, Xiong Yu, Soizick Lucas-Staat, Mart Krupovic, Stefan Schouten, David Prangishvili, Edward H Egelman

Publikováno v: eLife, Vol 6 (2017)

Biological membranes create compartments, and are usually formed by lipid bilayers. However, in hyperthermophilic archaea that live optimally at temperatures above 80°C the membranes are monolayers which resemble fused bilayers. Many double-stranded

Externí odkaz: https://doaj.org/article/180a770761fb4ee38f8c359bc9b3cc25

Novel haloarchaeal viruses from Lake Retba infecting Haloferax and Halorubrum species

Autor: Bina Prajapati, Mart Krupovic, Télesphore Sime-Ngando, Carolina Megumi Mizuno, Patrik Forterre, Hanna M. Oksanen, David Prangishvili, Soizick Lucas-Staat, Dennis H. Bamford

Publikováno v: Environmental Microbiology
Environmental Microbiology, 2019, Environmental viruses and their role in shaping ecosystems, 21 (6), pp.2129-2147. ⟨10.1111/1462-2920.14604⟩
Environmental Microbiology, Society for Applied Microbiology and Wiley-Blackwell, 2019, Environmental viruses and their role in shaping ecosystems, 21 (6), pp.2129-2147. ⟨10.1111/1462-2920.14604⟩

International audience; The diversity of archaeal viruses is severely undersampled compared with that of viruses infecting bacteria and eukaryotes, limiting our understanding on their evolution and environmental impacts. Here, we describe the isolati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b16042354e040c249ee7b181dfedd02
https://hal.science/hal-02362650/document

Author response: Model for a novel membrane envelope in a filamentous hyperthermophilic virus

Autor: Mart Krupovic, Soizick Lucas-Staat, Frank DiMaio, Edward H. Egelman, David Prangishvili, Peter M. Kasson, Xiong Yu, Stefan Schouten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47d89f2229586b6e58a693e9385742dc
https://doi.org/10.7554/elife.26268.020

Simple and elegant design of a virion egress structure in Archaea

Autor: Patrick Forterre, Sonja-Verena Albers, Soizick Lucas, Julia Reimann, David Prangishvili, Marie-Christine Prévost, Gérard Pehau-Arnaudet, Tessa E. F. Quax

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (8), pp.3354-9. ⟨10.1073/pnas.1018052108⟩
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (8), pp.3354-9. ⟨10.1073/pnas.1018052108⟩

Some viruses of Archaea use an unusual egress mechanism that involves the formation of virus-associated pyramids (VAPs) on the host cell surface. At the end of the infection cycle, these structures open outward and create apertures through which matu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6fd52f496f3364522e933575297b6b
https://doi.org/10.1073/pnas.1018052108