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A non-canonical mechanism of GPCR activation.

Autor: Powers AS; Department of Chemistry, Stanford University, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, USA., Khan A; Department of Quantitative Biosciences, Merck & Co., Inc., Rahway, NJ, USA.; Department of Therapeutic Proteins, Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA., Paggi JM; Department of Computer Science, Stanford University, Stanford, CA, USA.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, USA., Latorraca NR; Department of Computer Science, Stanford University, Stanford, CA, USA.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, USA.; Biophysics Program, Stanford University, Stanford, CA, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA., Souza S; Department of Quantitative Biosciences, Merck & Co., Inc., Rahway, NJ, USA., Di Salvo J; Evotec, Princeton, NJ, USA., Lu J; Department of Structural Chemistry, Merck & Co., Inc., West Point, PA, USA.; Small Molecule Discovery, Zai Lab (US) LLC, Cambridge, MA, USA., Soisson SM; Department of Structural Chemistry, Merck & Co., Inc., West Point, PA, USA.; Protein Therapeutics and Structural Biology, Odyssey Therapeutics, Boston, MA, USA., Johnston JM; Department of Modeling and Informatics, Merck & Co., Inc., Rahway, NJ, USA., Weinglass AB; Department of Quantitative Biosciences, Merck & Co., Inc., Rahway, NJ, USA., Dror RO; Department of Computer Science, Stanford University, Stanford, CA, USA. ron.dror@stanford.edu.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. ron.dror@stanford.edu.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. ron.dror@stanford.edu.; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, USA. ron.dror@stanford.edu.; Biophysics Program, Stanford University, Stanford, CA, USA. ron.dror@stanford.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 16; Vol. 15 (1), pp. 9938. Date of Electronic Publication: 2024 Nov 16.