Safety and immunogenicity of the novel plasmodium falciparum blood-stage vaccine RH5.1/AS01B in a phase I/IIA clinical trial

Autor: Minassian, AM, Silk, SE, Poulton, ID, Mitton, CH, Jin, J, Diouf, A, Querol-Rubiera, A, Bisnauthsing, K, Ogrina, T, Payne, RO, Folegatti, P, Silman, D, Batra, R, Brendish, N, Taylor, IJ, Smith, R, Berrie, E, Morelle, D, Lievens, M, Noe, AR, Soisson, LA, Ashfield, R, Long, CA, Goodman, AL, Faust, SN, Nugent, FL, Lawrie, AM, Draper, SJ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::4a29c34ec4a5e45a03d242f20df321cf
https://ora.ox.ac.uk/objects/uuid:2e266e0c-02d9-4c4a-9abc-2c5338750351

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Preclinical development of a stabilized RH5 virus-like particle vaccine that induces improved antimalarial antibodies.

Autor: King LDW; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Pulido D; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Barrett JR; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Davies H; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Quinkert D; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Lias AM; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Silk SE; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Pattinson DJ; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Diouf A; Laboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD 20852, USA., Williams BG; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., McHugh K; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Rodrigues A; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK., Rigby CA; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK., Strazza V; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK., Suurbaar J; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra LG 54, Ghana., Rees-Spear C; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK; London School of Hygiene and Tropical Medicine, WC1E 7HT London, UK., Dabbs RA; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Ishizuka AS; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Zhou Y; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Gupta G; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Jin J; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Li Y; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Carnrot C; Novavax AB, Kungsgatan 109, 753 18 Uppsala, Sweden., Minassian AM; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Campeotto I; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK., Fleishman SJ; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Noe AR; Leidos Life Sciences, Frederick, MD, USA., MacGill RS; Center for Vaccine Innovation and Access, PATH, Washington, DC 20001, USA., King CR; Center for Vaccine Innovation and Access, PATH, Washington, DC 20001, USA., Birkett AJ; Center for Vaccine Innovation and Access, PATH, Washington, DC 20001, USA., Soisson LA; USAID, 1300 Pennsylvania Avenue NW, Washington, DC 20004, USA., Long CA; Laboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD 20852, USA., Miura K; Laboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD 20852, USA., Ashfield R; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Skinner K; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Howarth MR; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK., Biswas S; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK., Draper SJ; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, OX1 3QU Oxford, UK; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, OX1 3QU Oxford, UK; The Jenner Institute, University of Oxford, Old Road Campus Research Building, OX3 7DQ Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address: simon.draper@bioch.ox.ac.uk.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2024 Jul 16; Vol. 5 (7), pp. 101654.

A phase IIa, randomized, double-blind, safety, immunogenicity and efficacy trial of Plasmodium falciparum vaccine antigens merozoite surface protein 1 and RTS,S formulated with AS02 adjuvant in healthy, malaria-naïve adults.

Autor: Cummings JF; Walter Reed Army Institute of Research, Silver Spring, MD, USA., Polhemus ME; Walter Reed Army Institute of Research, Silver Spring, MD, USA., Kester KE; Walter Reed Army Institute of Research, Silver Spring, MD, USA., Ockenhouse CF; Walter Reed Army Institute of Research, Silver Spring, MD, USA., Gasser RA Jr; Walter Reed Army Institute of Research, Silver Spring, MD, USA., Coyne P; Walter Reed Army Institute of Research, Silver Spring, MD, USA., Wortmann G; Walter Reed Army Institute of Research, Silver Spring, MD, USA., Nielsen RK; Walter Reed Army Institute of Research, Silver Spring, MD, USA., Schaecher K; Walter Reed Army Institute of Research, Silver Spring, MD, USA., Holland CA; Walter Reed Army Institute of Research, Silver Spring, MD, USA., Krzych U; Walter Reed Army Institute of Research, Silver Spring, MD, USA., Tornieporth N; GSK, Wavre, Belgium(2)., Soisson LA; Malaria Vaccine Development Program, United States Agency for International Development, Washington, DC, USA., Angov E; Walter Reed Army Institute of Research, Silver Spring, MD, USA. Electronic address: Evelina.angov.civ@health.mil., Heppner DG; Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Publikováno v: Vaccine [Vaccine] 2024 Apr 30; Vol. 42 (12), pp. 3066-3074. Date of Electronic Publication: 2024 Apr 06.

First-in-human assessment of safety and immunogenicity of low and high doses of Plasmodium falciparum malaria protein 013 (FMP013) administered intramuscularly with ALFQ adjuvant in healthy malaria-naïve adults.

Autor: Hutter JN; Walter Reed Army Institute of Research, Silver Spring, MD, United States. Electronic address: jack.n.hutter.mil@health.mil., Robben PM; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Lee C; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Hamer M; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Moon JE; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Merino K; Walter Reed Army Institute of Research, Silver Spring, MD, United States; Current Affiliation: Division of Immunology, Tulane National Primate Research Center Covington, LA, United States., Zhu L; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Galli H; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Quinn X; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Brown DR; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Duncan E; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Bolton J; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Zou X; Navy Medical Research Center, Silver Spring, United States., Angov E; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Lanar DE; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Rao M; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Matyas GR; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Beck Z; Walter Reed Army Institute of Research, Silver Spring, MD, United States; Henry Jackson Foundation for Advancement of Military Medicine, Bethesda, MD. Present Address: Pfizer, Inc., 401 N Middletown Rd, Pearl River, New York 10965, United States., Bergmann-Leitner E; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Soisson LA; United States Agency for International Development Malaria Vaccine Development Program, Washington DC, United States., Waters NC; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Ngauy V; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Regules J; Walter Reed Army Institute of Research, Silver Spring, MD, United States., Dutta S; Walter Reed Army Institute of Research, Silver Spring, MD, United States. Electronic address: sheetij.dutta.civ@health.mil.

Publikováno v: Vaccine [Vaccine] 2022 Sep 22; Vol. 40 (40), pp. 5781-5790. Date of Electronic Publication: 2022 Aug 31.