Výsledky vyhledávání - "Soininen, P. (Pasi)"

Total liver phosphatidylcholine content associates with non-alcoholic steatohepatitis and glycine N-methyltransferase expression

Autor: Männistö, V. (Ville), Kaminska, D. (Dorota), Kärjä, V. (Vesa), Tiainen, M. (Mika), de Mello, V. D. (Vanessa D.), Hanhineva, K. (Kati), Soininen, P. (Pasi), Ala‐Korpela, M. (Mika), Pihlajamäki, J. (Jussi)

Background & Aims: Alterations in liver phosphatidylcholine (PC) metabolism have been implicated in the pathogenesis of non‐alcoholic fatty liver disease (NAFLD). Although genetic variation in the phosphatidylethanolamine N‐methyltransferase (PEM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::681d41d4229f0000cb99159560d51199
http://urn.fi/urn:nbn:fi-fe2019111943209

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Nuclear magnetic resonance‐based metabolomics identifies phenylalanine as a novel predictor of incident heart failure hospitalisation:results from PROSPER and FINRISK 1997

Autor: Delles, C. (Christian), Rankin, N. J. (Naomi J.), Boachie, C. (Charles), McConnachie, A. (Alex), Ford, I. (Ian), Kangas, A. (Antti), Soininen, P. (Pasi), Trompet, S. (Stella), Mooijaart, S. P. (Simon P.), Jukema, J. W. (J. Wouter), Zannad, F. (Faiez), Ala‐Korpela, M. (Mika), Salomaa, V. (Veikko), Havulinna, A. S. (Aki S.), Welsh, P. (Paul), Würtz, P. (Peter), Sattar, N. (Naveed)

Aims: We investigated the association between quantified metabolite, lipid and lipoprotein measures and incident heart failure hospitalisation (HFH) in the elderly, and examined whether circulating metabolic measures improve HFH prediction. Methods a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::fd93bf02475497edb7bf4a0e085d8124
http://urn.fi/urn:nbn:fi-fe2018082333986

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Association of circulating metabolites with healthy diet and risk of cardiovascular disease:analysis of two cohort studies

Autor: Akbaraly, T. (Tasnime), Würtz, P. (Peter), Singh-Manoux, A. (Archana), Shipley, M. J. (Martin J.), Haapakoski, R. (Rita), Lehto, M. (Maili), Desrumaux, C. (Catherine), Kähönen, M. (Mika), Lehtimäki, T. (Terho), Mikkilä, V. (Vera), Hingorani, A. (Aroon), Humphries, S. E. (Steve E.), Kangas, A. J. (Antti J.), Soininen, P. (Pasi), Raitakari, O. (Olli), Ala-Korpela, M. (Mika), Kivimäki, M. (MIka)

Diet may modify metabolomic profiles towards higher or lower cardiovascular disease (CVD) risk. We aimed to identify metabolite profiles associated with high adherence to dietary recommendations — the Alternative Healthy Eating Index (AHEI) — and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::2adc3d5cdce529c66928e35ad57f87d2
http://urn.fi/urn:nbn:fi-fe2018081633724

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Metabolic proﬁling of fatty liver in young and middle-aged adults:cross-sectional and prospective analyses of the young Finns study

Autor: Kaikkonen, J. E. (Jari E.), Würtz, P. (Peter), Suomela, E. (Emmi), Lehtovirta, M. (Miia), Kangas, A. J. (Antti J.), Jula, A. (Antti), Mikkilä, V. (Vera), Viikari, J. S. (Jorma S.A.), Juonala, M. (Markus), Rönnemaa, T. (Tapani), Hutri-Kähönen, N. (Nina), Kähönen, M. (Mika), Lehtimäki, T. (Terho), Soininen, P. (Pasi), Ala-Korpela, M. (Mika), Raitakari, O. T. (Olli T.)

Nonalcoholic fatty liver is associated with obesity-related metabolic disturbances, but little is known about the metabolic perturbations preceding fatty liver disease. We performed comprehensive metabolic profiling to assess how circulating metaboli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::18eca64629cdf12a05ade4a6f8fe2f0c
http://urn.fi/urn:nbn:fi-fe201703245835

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Quantitative serum nuclear magnetic resonance metabolomics in large-scale epidemiology:a primer on -omic technologies

Autor: Würtz, P. (Peter), Kangas, A. J. (Antti J.), Soininen, P. (Pasi), Lawlor, D. A. (Debbie A.), Smith, G. D. (George Davey), Ala-Korpela, M. (Mika)

Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel biomarkers for cardiometabolic diseases and clarified the molecular associations of established risk factors. A quantitative metabolomics platform based on nuclear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::91edca84a334d6f248eb3d34659e65e6
http://urn.fi/urn:nbn:fi-fe201801182109

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Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

Autor: Davis, J. P. (James P.), Huyghe, J. R. (Jeroen R.), Locke, A. E. (Adam E.), Jackson, A. U. (Anne U.), Sim, X. (Xueling), Stringham, H. M. (Heather M.), Teslovich, T. M. (Tanya M.), Welch, R. P. (Ryan P.), Fuchsberger, C. (Christian), Narisu, N. (Narisu), Chines, P. S. (Peter S.), Kangas, A. J. (Antti J.), Soininen, P. (Pasi), Ala-Korpela, M. (Mika), Kuusisto, J. (Johanna), Collins, F. S. (Francis S.), Laakso, M. (Markku), Boehnke, M. (Michael), Mohlke, K. L. (Karen L.)

Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based association tests between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::00b14723286c72d03653187a8ebb6bd5
http://urn.fi/urn:nbn:fi-fe2017120555338

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The biomarker and causal roles of homoarginine in the development of cardiometabolic diseases:an observational and Mendelian randomization analysis

Autor: I. S. (Ilkka Seppälä), Oksala, N. (Niku), Jula, A. (Antti), Kangas, A. J. (Antti J.), Soininen, P. (Pasi), Hutri-Kähönen, N. (Nina), März, W. (Winfried), Meinitzer, A. (Andreas), Juonala, M. (Markus), Kähönen, M. (Mika), Raitakari, O. T. (Olli T.), Lehtimäki, T. (Terho)

High L-homoarginine (hArg) levels are directly associated with several risk factors for cardiometabolic diseases whereas low levels predict increased mortality in prospective studies. The biomarker role of hArg in young adults remains unknown. To stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::1593eb5d434d9e931247112dc4c4530b
http://urn.fi/urn:nbn:fi-fe201706287550

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Epidemiological applications of quantitative serum NMR metabolomics:causal inference from observational studies

Autor: Wang, Q. (Qin)

Cardiovascular diseases are the leading cause of death worldwide and type 2 diabetes is reaching a global epidemic. Epidemiological studies have identified numerous risk factors and pharmacotherapies in relation to these cardiometabolic diseases. How

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::78f6c3dd17bef4f3dc1c76ca34591bc9
http://urn.fi/urn:isbn:9789526215082

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