Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Soichiro Ide"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Opioid addiction and the opioid overdose epidemic are becoming more serious, and the development of therapeutic agents is essential for the pharmacological treatment of substance use disorders. The κ-opioid receptor (KOP) is a member of the
Externí odkaz:
https://doaj.org/article/4f9c9cb4a3394d6bae338d3b6b6bc1f6
Autor:
Yuki Moriya, Yoshiyuki Kasahara, Masafumi Shimada, Yasufumi Sakakibara, Hideaki Fujii, Hiroshi Nagase, Soichiro Ide, Kazutaka Ikeda, F. Scott Hall, George R. Uhl, Ichiro Sora
Publikováno v:
Journal of Pharmacological Sciences, Vol 151, Iss 3, Pp 135-141 (2023)
Previous pharmacological data have shown the possible existence of functional interactions between μ- (MOP), κ- (KOP), and δ-opioid receptors (DOP) in pain and mood disorders. We previously reported that MOP knockout (KO) mice exhibit a lower stre
Externí odkaz:
https://doaj.org/article/09bb7dc779c5447daf3862372f76af88
Autor:
Miho Tanaka, Atsushi Sato, Hiroko Kotajima‐Murakami, Hirofumi Kashii, Yoko Hagino, Soichiro Ide, Kazutaka Ikeda
Publikováno v:
Neuropsychopharmacology Reports, Vol 42, Iss 3, Pp 343-346 (2022)
Abstract Aim Previous studies reported that advanced paternal age (APA) may increase the risk of autism spectrum disorder (ASD) in offspring. However, effects of APA on behaviors have not been investigated in offspring of the same paternal mice. The
Externí odkaz:
https://doaj.org/article/d738b62ce85c40ed84c48da74b6c622b
Autor:
Dae Hee Han, Ilgang Hong, Ja Eun Choi, Pojeong Park, Jun-Yeong Baek, HyoJin Park, Soichiro Ide, Masayoshi Mishina, Kazutaka Ikeda, Bong-Kiun Kaang
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-5 (2021)
Abstract Ketamine, a non-competitive antagonist of the N-methyl-d-aspartate receptor (NMDAR), generates a rapidly-acting antidepressant effect. It exerts psychomimetic effects, yet demands a further investigation of its mechanism. Previous research s
Externí odkaz:
https://doaj.org/article/13ad37c1b36147509b95aace83a1495e
Publikováno v:
Neuropsychopharmacology Reports, Vol 41, Iss 2, Pp 124-133 (2021)
Abstract Addiction has become a major worldwide medical, public health, and social problem. Because the prevalence of addiction varies widely geographically, due to differences in ethnicity, culture, education, social environment, and regulation, eac
Externí odkaz:
https://doaj.org/article/955291ffc3184935a39c6d5b21d892da
Autor:
Kazutaka Ikeda, Soichiro Ide, Hiromi Takahashi-Omoe, Masabumi Minami, Hisatsugu Miyata, Mitsuo Kawato, Hitoshi Okamoto, Tetsuro Kikuchi, Yumiko Saito, Tomoaki Shirao, Yuko Sekino, Toshiya Murai, Toshihiko Matsumoto, Masako Iseki, Yoko Nishitani, Masahiko Sumitani, Hidehiko Takahashi, Shigeto Yamawaki, Tadashi Isa, Yoko Kamio
Publikováno v:
Taiwanese Journal of Psychiatry, Vol 35, Iss 1, Pp 6-11 (2021)
Background: The term “addiction” encompasses both substance dependence and behavioral addiction and is associated with major societal problems. Measures to combat addiction are currently insufficient in Japan, and further research on addiction is
Externí odkaz:
https://doaj.org/article/5a194c2adc36401cb63271102dffb745
Publikováno v:
Neuropsychopharmacology Reports, Vol 40, Iss 4, Pp 324-331 (2020)
Abstract Aims G protein‐activated inwardly rectifying potassium (GIRK) channels are related to rewarding effects of addictive drugs. The GIRK2 subunit is thought to play key roles in the reward system. Weaver mutant mice exhibit abnormal GIRK2 func
Externí odkaz:
https://doaj.org/article/d30ceea3413640798bc95d50dbd40a0a
Caenorhabditis Elegans Exhibits Morphine Addiction-like Behavior via the Opioid-like Receptor NPR-17
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Addiction has become a profound societal problem worldwide, and few effective treatments are available. The nematode Caenorhabditis elegans (C. elegans) is an excellent invertebrate model to study neurobiological disease states. C. elegans reportedly
Externí odkaz:
https://doaj.org/article/d59a2f586e194e9fb3238f5ab2714d03
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2552 (2022)
Substance use disorders (SUDs) are chronic, lifelong disorders that have serious consequences. Repeated substance use alters brain function. G-protein-activated inwardly rectifying potassium (GIRK) channels are expressed widely in the brain, includin
Externí odkaz:
https://doaj.org/article/8194bf1a29484148bc3a5df51980f625
Publikováno v:
Neuropsychopharmacology Reports, Vol 38, Iss 4, Pp 182-188 (2018)
Abstract Aims The bed nucleus of the stria terminalis (BNST) is a limbic structure mediating autonomic and neuroendocrine responses and negative affective states such as anxiety and fear. We previously demonstrated that noradrenergic transmission via
Externí odkaz:
https://doaj.org/article/c8800260d7064e9884a746e60cb55f67