Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit

Autor: Thomas Bertero, Katherine A. Cottrill, Yu Lu, Christina M. Haeger, Paul Dieffenbach, Sofia Annis, Andrew Hale, Balkrishen Bhat, Vivek Kaimal, Ying-Yi Zhang, Brian B. Graham, Rahul Kumar, Rajan Saggar, Rajeev Saggar, W. Dean Wallace, David J. Ross, Stephen M. Black, Sohrab Fratz, Jeffrey R. Fineman, Sara O. Vargas, Kathleen J. Haley, Aaron B. Waxman, B. Nelson Chau, Laura E. Fredenburgh, Stephen Y. Chan

Publikováno v: Cell Reports, Vol 13, Iss 5, Pp 1016-1032 (2015)

Pulmonary hypertension (PH) is a deadly vascular disease with enigmatic molecular origins. We found that vascular extracellular matrix (ECM) remodeling and stiffening are early and pervasive processes that promote PH. In multiple pulmonary vascular c

Externí odkaz: https://doaj.org/article/f5da7c8f7754420ab4de6ee73b9f1bf3

Evolution of right ventricular size over time after tetralogy of Fallot repair: a longitudinal cardiac magnetic resonance study

Autor: P. Ewert, Sohrab Fratz, Susanne Naumann, Heiko Stern, Stefan Martinoff, T. Rutz, Rüdiger Lange, Fransis Ghandour, Christian Meierhofer

Publikováno v: European Heart Journal - Cardiovascular Imaging. 18:364-370

Aims It is commonly believed that pulmonary regurgitation (PR) after surgical repair of tetralogy of Fallot (TOF) leads to progressive right ventricular (RV) enlargement. However, progressive RV dilatation has never clearly been documented in this pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f53b7fafa41fe08a1c4330f5517fb8c
https://doi.org/10.1093/ehjci/jew273

VIEWING ONLY POSTERS1323Evaluation of right ventricular transverse strain and strain rate in patients with acute ST-segment elevation myocardial infarction: a cardiac magnetic resonance feature tracking study1333Cardiac resynchronization in ischemic heart failure patients: a comparison between therapy guided by cardiac magnetic resonance imaging and 2D-speckle tracking echocardiography1338Cardiac magnetic resonance versus bisphosphonate scintigraphy for diagnosis of cardiac amyloidosis1341Strain relaxation index, a novel tagged MRI-derived diastolic function parameter, is impaired in metabolic syndrome1349Global Longitudinal Strain Predicts Chronic Myocardial Infarction in Patients with Normal Ejection Fraction1352Optimal Dose Of Dobutamine During Low-Dose Dobutamine Stress Echocardiography In Correctly Identify Viable Segments On Cardiovascular Magnetic Resonance1368Absolute wall thickening and left ventricular ejection fraction–a unifying theory of myocardial contraction and heart failure?1376Transient St Elevation in Acs Like Myocarditis1379Patients after Fontan with a 'total cavopulmonary connection' Fontan modification develop more collateral flow compared to 'old-fashioned' Fontan modifications1387A MRI–derived 3D patient specific model for fibrosis quantification in atrial fibrillation1391Scar burden and survival in patients with ischemic cardiomyopathy and poor LV ejection fraction1392Relation of inflammatory markers with myocardial and microvascular injury in patients with reperfused ST- elevation myocardial infarction1406Equivalence of segmented conventional and fast single-shot late gadolinium enhancement (LGE) techniques for1410Cardiac Mri Appearances of Tuberculosis - A Review of Varied Presentations in India1415Atheroma burden, cardiac remodelling and epicardial fat: A comparison between healthy South Asian and European adults using Whole Body Cardiovascular MR1418Symptomatic Ventricular Arrhythmias: Diagnostic Yield of Cardiac Magnetic Resonance1421CMR assessment of aortic stiffness in asymptomatic low risk patients with type 2 diabetes mellitus1436Shock index as a predictor of myocardial damage and clinical outcome in ST-elevation myocardial infarction1451Combined biomarker testing for the prediction of microvascular obstruction after primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction1452A novel oscillometric technique compared with cardiac magnetic resonance for the assessment of aortic pulse wave velocity in ST-segment elevation myocardial infarction1456Aorto-pulmonary collaterals evaluated by CMR is associated to reduced 'effective' cardiac index late after Fontan palliation1458Evaluation of pulmonary transit time and Pulmonary Blood Volume with first-pass perfusion CMR imaging in adult with repaired Congenital Heart disease1459Prognostic value of the cardiac magnetic resonance as a predictor of improvement in ventricular function after TakoTsubo syndrome1462Diagnostic performance of ECG detection of left atrial enlargement in patients with arterial hypertension relative to the cardiac magnetic resonance gold-standard: impact of obesity1463Utility of cardiac magnetic resonance imaging for diagnosis of cardiac sarcoidosis and prediction of therapeutic effects in patients with complete heart block and implanted magnetic resonance-conditional pacemaker: A multicenter study1467Cardiac magnetic resonance late gadolinium enhancement in patients with genetic dilated cardiomyopathy14712.Left ventricular hypertrophy in hypertensive patients–comparison of Cardiac Magnetic Resonance and Echocardiographic analysis of morphological and functional LV-parameters1472Is Angiographic Perfusion Score assessed in patients with acute myocardial infarction correlated with Cardiac Magnetic Resonance infarct size and N-terminal pro-brain natriuretic peptide in 6-month follow-up1476Cardiac Magnetic Resonance Patterns of Left Ventricular Diastolic Function In Hypertrophic Cardiomyopathy1477Impact of platelet volume on thrombus burden and tissue reperfusion in patients with STEMI treated with primary angioplasty: MRI study1479Right ventricle systolic function assessment and its prognostic implications in cardiac amyloidosis1484Cardiac MRI - an important tool in the evaluation of multsystemic inflamatory diseases. An Erdheim-Chester Disease case report1485Predictive value of cardiac magnetic resonance for future adverse cardiac events in patients with ST-segment elevation myocardial infarction1486Time-to-treatment but not thrombectomy influence infarct size and microvascular obstruction in patients with acute ST-segment elevation myocardial infarction treated with primary coronary intervention1489Primary PCI versus Early Routine Post Fibrinolysis PCI for ST Elevation Myocardial Infarction1490Evaluation of ventricular function in Fontan patients undergoing feature tracking magnetic resonance strain1491Impacts of atrialized right ventricle and left ventricular displacement in Ebstein's anomaly on left ventricular function assessed by cardiovascular MRI1494Final diagnosis for patients presenting with chest pain, electrocardiographic changes or troponin rise and normal coronary arteries: insights from Cardiovascular MRI in our population1495Early Predictive Factors of LV Remodeling after STEMI; Assessment by Coronary Angiogram and Cadiovascular Magnetic Resonance1497The Pathobiologic Mechanisms and the Prognostic Meaning of t wave Inversion in Acute Myocarditis. a Study Performed by Cardiac Magnetic Resonance1501The Influence of Left Atrial Function on Exercise Tolerance in Patients with Heart Failure and Preserved Ejection Fraction: A Cardiac Magnetic Resonance Feature Tracking Study1504Microvascular Obstruction in Patients with Anterior ST-Elevation Myocardial Infarction who Underwent Primary Percutaneous Coronary Intervention: Predictors and Impact on the Left Ventricular Function1508Histological Validation of ECV Quantification by Cardiac Magnetic Resonance T1 Mapping in Cardiac Amyloidosis1513Comparative Evaluation of Flow Quantification Across the Atrioventricular Valve in Patients with Functional Univentricular Heart After Fontan's Surgery and Healthy Controls: Measurement by 4D Flow Magnetic Resonance Imaging and Streamline Visualization1515Does arterial switch for d-transposition of the great arteries alter myocardial deformation of the ventricles?1527Accuracy of T1 Mapping by multi-professional CMR operators to predict myocardial infarct1531Detecting hypertensive heart disease: the additive value of cardiovascular magnetic resonance imaging1534Diagnostic Performance of Cardiac Magnetic Resonance Strain Parameters in Assesment of Myocardial Ischemia1535Relationships between left ventricular filling pressures and longitudinal dysfunction with myocardial fibrosis in uncomplicated hypertensive patients1539Predictive Clinical Factors of Tissue Damage Severity in Reperfused Acute Myocardial Infarction as Visualized by Cardiac Magnetic Resonance1541Which CMR derived parameter predicts better the need of invasive treatment in aortic coarctation?1543Contrast-enhanced magnetic resonance tomography in patients with supraventricular tachyarrhythmias1546Prognostic Value of CMR Imaging Biomarkers on Outcome in Peripheral Arterial Disease: a 6-year Follow-up Pilot Study1549Dobutamine-Stress-CMR in Young Adults after Arterial Switch Operation as Neonates1553Impact of posteromedial papillary muscle infarction on mitral regurgitation after ST-segment elevation myocardial infarction1556Role of cardiac magnetic resonance imaging in assessment of left ventricular hypertrophy1569Using intrinsic Cardiac Shear Waves to measure Myocardial Stiffness: Preliminary results from Patients with Heart failure with preserved Ejection Fraction1571Relationship of cerebrovascular reactivity and MRI pattern of carotid atherosclerotic plaque1577Feasibility study of an MR conditional pedal ergometer for cardiac stress MRI–preliminary results in healthy volunteers and patients with suspected coronary artery disease1581Pulmonary valve replacement for severe pulmonary stenosis has a positive effect on left ventricular remodeling1582The RV after cardiac surgery, more resilient than thought: multiparametric quantification shows altered rather than reduced function1584Usefulness of cardiovascular magnetic resonance to differentate coronary artery disease from non ischemic cardiomyoptathy in patients with heart failure1593What does CMR add to the ESC Risk Prediction Model to Assess the Occurrence of Sudden Cardiac Death in Patients with HCM?1597Detecting Progression of Diffuse Interstitial Fibrosis in Alstrom Syndrome1612Diffuse fibrosis in the ventricles of patients with transposition of great arteries late after atrial switch1631Utility of Cardiac Magnetic Resonance in the diagnosis and stratification of arrhythmic risk in patients with confirmed or suspected ventricular arrhythmias1635Size matters: pulmonary veins geometry by cardiac magnetic resonance imaging in atrial fibrillation patients1642How do the differences in Left Ventricular wall measurements from Echocardiography and CMR in patients with Hypertrophic Cardiomyopathy affect current Sudden Cardiac Death Risk Scores?1651Noninvasive assessment of intracardiac viscous energy loss in Fontan patients from 4D Flow CMR1653Behcet and Myocardial Infarction: A Rare Combination1328Impact of New Cerebral Ischemic Lesions On the Occurrence of Delirium after Transcatheter Aortic Valve Implantation1329Heart T2* assessment to measure iron overload using different software tools in patients with Thalassemia Major1332Hypertrabeculated Left Ventricle at Cardiac Magnetic Resonance Imaging: β-Thalassemia Major vs. Left Ventricular Non -Compaction Disease1335Aortic Regurgitation following Transcatheter Aortic Valve Implantation (TAVI): a CMR Study of two prosthesis designs1336Incremental value of semi-quantitative evaluation of myocardium perfusion with 3T stress cardiac MRI1343Left ventricular morphological quantification with single shot and free-breathing SSFP cine imaging compared with standard breath-hold SSFP cine imaging1344Changes of cardiac iron and function during pregnancy in transfusion-dependent thalassemia patients1346Significant improvement of survival by T2* MRI in thalassemia major1350The impact of trans-catheter aortic valve implantation induced left-bundle branch block on cardiac reverse remodelling1351Value of magnetic resonance myocardial perfusion imaging in patients with indeterminate coronary computed tomography angiography results1353Gender differences in response to Transcatheter Aortic Valve implantation in patients with severe aortic stenosis assessed by feature tracking1354A qualitative assessment of first-pass perfusion bolus timings in the assessment of myocardial ischemia: A magnetic resonance study1355MRI prospective survey on cardiac iron and function and on hepatic iron in non transfusion-dependent thalassemia intermedia patients treated with desferrioxamine or non chelated1358Coronary Calcification Compromises Myocardial Perfusion Irrespective of Luminal Stenosis1359Non–contrast three–dimensional magnetic resonance imaging for pre–procedural assessment of aortic annulus dimensions in patients undergoing transcatheter aortic valve implantation1360'Systolic ventricularization' of the left atrium with bileaflet mitral valve prolapse: impact on quantification of mitral regurgitation1361CMR assessment of left ventricular remodeling 6 months after percutaneous edge-to-edge repair using Mitraclip1363Accuracy of Transthoracic Echocardiography (TTE) in comparison with Cardiac Magnetic Resonance (CMR)1374CMR for myocardial iron overload assessment: a new calibration curve from the MIOT project1381Can Speckle Tracking Imaging Reveal Myocardial Iron Overload in Thalassemia Major? A Combined Echocardiography and Cardiac Magnetic Resonance Study1382Native myocardial T1 mapping in patients with pulmonary hypertension and age matched volunteers1384A Insidious Line Between Thalassemia Intermedia And Left Ventricular Non-Compaction Disease: The Role Of Cardiac Magnetic Resonance1388Pulmonary Artery : Ascending Aorta Diameter - An Important and Easily Measureable Prognostic Parameter1394Novel carotid artery ultrasound index–Extra-media thickness and a well-established cardiac magnetic resonance fat quantification method1403Validation of CMR-derived LVOT diameters against direct in-vivo measurements1409Early myocardial perfusion measured by CMR in acute myocardial infarction treated by primary PCI–a postconditioning study1420Assessment of paravalvular aortic regurgitation after transcatheter aortic valve implantation using cardiac magnetic resonance imaging: a comparative study with echocardiography and angiography1422Left atrial strain measured by feature tracking predicts left ventricular end diastolic filling pressure1426Validation of extracellular volume equation by serial cardiac magnetic resonance imaging measurements in patients with varying hematocrit1427Assessing diastolic function applying Cardiovascular Magnetic Resonance - comparison with the gold standard1475Role of Adenosine Stress Cardiac Mri in the Setting of Chronic Total Occlusion of Coronary Arteries1520Aortic Elasticity Indexes by Magnetic Resonance Predict Progression of Ascending Aorta Dilation1522Combined atrioventricular assessment of diastolic function by cardiac magnetic resonance1537Safety, image quality and clinical utility of cardiac magnetic resonance in patients with antiarrhythmic devices1538Usefulness of cardiac magnetic resonance to predict the need for surgical procedures in patients with mitral regurgitation1550Normal T1, T2, T2* and extracellular volume reference values in healthy volunteers at 3 Tesla cardiac magnetic resonance1551Comprehensive intra-ventricular myocardial deformation strain analysis in healthy volunteers: implications for regional myocardial disease processes1557Elastic properties changes of aorta in patients with dilatation of the ascending aorta evaluated by Magnetic Resonance1558The prevalence of active myocarditis assessed by cardiovascular magnetic resonance in patients with clinically suspected myocarditis1563Quantitative assessment of myocardial scar heterogeneity using texture analysis to risk stratify post–MI patients for ICD insertion1564Gender differences in exercise capacity and LV remodeling in response to pressure overload in aortic stenosis1572Myocardial wall stress as a novel CMR measure to assess cardiac function1573Feature tracking cardiac magnetic resonance to assess LV mechanics in pressure and volume overload1574Safety, feasibility and clinical impact of Cardiovascular Magnetic Resonance in patients with MR-conditional devices1576T1 Mapping at 1-Year Following Aortic Valve Replacement: Baseline Geometry Defines Magnitude of Fibrosis Regression1583Normal values of LV global myocardial mechanics using two and three-dimensional cardiovascular magnetic resonance1585Prediction of infarct transmurality in acute myocardial infarction based on cardiac magnetic resonance deformation analysis1595Measuring invasive blood pressure by catheters guided solely by Cardiovascular Magnetic Resonance by using a new guidewire without the need of a hybrid CMR-fluoroscopy suite1599Influence of active and passive cardiac implants on CMR image quality: results from a consecutive patient series1600Reproducibility of aortic 4D flow measurements in healthy volunteers1601An automatic approach to extract 4D flow hemodynamic markers: application in BAV-affected patients1602Global myocardial mechanics with 2 and 3-Dimensional cardiovascular magnetic resonance feature tracking in patients with myocarditis1603A CMR-based clinician-friendly assessment of in vivo left ventricle hemodynamics1604Reproducibility of left atrial strain using cardiovascular magnetic resonance myocardial feature tracking1605The severity of myocardial infarction in STEMI, determined by transmurality of infarct and infarct characteristics, impacts on myocardial T2 values1606MicroRNA as potential biomarkers of acute myocardial damage following STEMI1607Myocardial blush grade is associated with microvascular obstruction on CMR following STEMI16084D Flow CMR imaging: Comparison of conventional parallel imaging and variable density k-t acceleration1609In-vitro comparison of segmented-gradient-echo versus non-segmented echo planar imaging 4D Flow CMR: validation of flow volume and 3D vortex ring assessment1614Not just 2D but also 4D flow measurements in pulsatile phantom are accurate and reproducible1615Diffusion Tensor Imaging: Comparison of Hypertrophic Cardiomyopathy, Hypertension and Healthy Cohorts1624Impact of myocardial fibrosis measured by cardiac magnetic resonance imaging on reverse left ventricular remodelling after transcatheter aortic valve implantation1625Prosthetic valve regurgitation after transcatheter aortic valve implantation with new-generation devices compared to surgical aortic valve replacement–a cardiac magnetic resonance imaging flow measurement analysis1637Assessment of Aortic and Pulmonary Artery stiffness in Patients with COPD using Cardiac Magnetic Resonance1638Myocardial Mechanics implications using 2D Cardiovascular Magnetic Resonance in Aortic Regurgitation1639Delineation of myocardial infarction & viability by 12 lead ECG vs cardiac magnetic resonance1641Regional variation in native T1 values in normal healthy volunteers?1645Feasibility of myocardial strain assessment using tissue tracking at 3.0T CMR following ST-segment elevation myocardial infarction1648Diagnostic Impact of Cardiac Magnetic Resonance in patients with acute chest pain, troponin elevation and no significant angiographic coronary artery disease

Autor: João Pais, Sheraz A. Nazir, Amardeep Ghosh Dastidar, GL. Alonso Salinas, Estefania De Garate, Constanze Merten, Laura-Ann McGill, Ana Beatriz Solana, Mohammed S.M. Elbaz, Kaoru Tanaka, Elisa McAlindon, R. Hinojar, Chiara Baggi, B. Berlot, Filippo Piatti, RLF. van der Palen, Sebastian Hilbert, Sohrab Fratz, F. Valente, TA. Treibel, A. Baritussio, Alessandra Scatteia, Thu-Thao Le, Anvesha Singh, TGJ Gibbs, Tomasz Brzostowicz, Katarzyna Katulska, Clotilde Roy, Begoña Igual, Begoña Igual-Muñoz, G.D. Aquaro, Giovanni Donato Aquaro, Giovanni Malanchini, J. Kermer, Siri Lagethon Heck, JRJ. Foley, Najime Bouhzam, Anne Bethke, Sajid Aslam, Maciej Haberka, Andreas A. Kammerlander, F. Macaione, Laura Saunders, F. Pizzino, A. Meloni, D. Leone, Bernard P. Paelinck, Gabriella Vincenti, Marco Barbanti, Michael Y. Henein, S. Matthew, C. Schneeweis, LE. Dobson, Antonella Meloni, C. Richmond, Chun-Ho Yun, TA. Musa, Chiodi Elisabetta, Masieh Abawi, M. Bensaoud, Vivian P. Kamphuis, Jessica Webb, Giulia Vinco, N. Shehu, S. Baig, Theano Papavassiliu, Juan Sztajzel, Menacho Katia, M.M. Winter, Agnes Mayr, A.S. Maksimova, aSara E. Fawal, Klug Gert, M. Frick, Harrie CM. van den Bosch, O.V. Mochula, B. Igual Muñoz, Begoña Igual Muñoz, Carla Contaldi, Max Charalambos, G. Bainbridge, B.E.U. Burkhardt, Hoi Lam She, Franz Duca, Ahmad A. Mahmoud, M. von Roeder, Alberto Cipriani, Arthur Cescau, Albert TEIS, Akio Inage, Sameh Mohamed Shaheen, J. Rajewska-Tabor, R. Bica, Luís Almeida-Morais, Nazario Carrabba, P. Agudo-Quílez, Agata Brzozowska-Czarnek, Alexandra Sousa, Makoto Orii, Tamas Erdei, A. Tercero Martínez, L. Ait Ali, P. Festa, Hans-Josef Feistritzer, Sebastian J. Reinstadler, Rachel Kan, Claudia Camaioni, Jonathan Weir-McCall, Zeeshan S. A. Lakhani, K. Arnhold, Martin Reindl, E. Nyktari, Maddalena Valinoti, Naira Mkrtchyan, Giuseppe Gibelli, Jonathan Rodrigues, E. Abdul Rahman, GJ. Fent, Ricardo Ladeiras-Lopes, Chrysanthos Grigoratos, Tomas Lapinskas, Paulius Bucius, Augustinas P. Fedaravicius, Laura Urbonaite, Agnieta Stabinskaite, Remigijus Zaliunas, Cannizzaro Maria Teresa, De Falco Alfano Daniele, Riccardo Righi, Michela Zerbini, Positano Vincenzo, Corrado Cittanti, Melchiore Giganti, Benea Giorgio, Dario Genovesi, Assuero Giorgetti, Sara Chiappino, Andrea Barison, Giuseppe Vergaro, Giancarlo Todiere, Michele Emdin, Paolo Marzullo, Henrique Turin-Moreira, Nuno Bettencourt, Ricardo Fontes-Carvalho, Francisco Sampaio, Bharath Ambale-Venkatesh, Colin Wu, Kiang Liu, Alain Bertoni, Pamela Ouyang, David Bluemke, João Lima, P. Garg, JF. Foley, P. Haaf, JP. Greenwood, S. Plein, PP. Swoboda, JR. Ismail, R. Najme Khir, CW. Lim, N. Chua, ZO. Ibrahim, HA. Zainal Abidin, MK. Mohd Arshad, SS. Kasim, Ben Rooms, Katie Hyde, Stephen Rohan, Mark Hamilton, Chiara Bucciarelli‐Ducci, Angus Nightingale, Julian Paton, Nathan Manghat, David MacIver, Walter Demolli, Alessandra Russo, Chiara Minoia, Salvatore Biasi, Christin Eltschkner, Meierhofer Christian, Peter Ewert, Stefan Martinoff, Heiko Stern, Claudio Fabbri, Roberto Mantovan, Stefano Severi, Cristiana Corsi, V. Vassiliou, M. Arzanauskaite, C. Izgi, W. Lam, S. Prasad, Sebastian Johannes Reinstadler, Gert Klug, Johannes Mair, Werner Jaschke, Wolfgang-Michael Franz, Bernhard Metzler, F. Muehlberg, S. Fritschi, S. Funk, M. Prothmann, F. von Knobelsdorff-Brenkenhoff, J. Schulz-Menger, B. Mohan, G A. karthik, Vimal Raj, Deirdre B Cassidy, Jill JF Belch, Stephen J Gandy, Graeme Houston, Matthew A Lambert, Roberta Littleford, Janice Rowland, Allan D Struthers, Faisel Khan, Marjorie Salel, Alexia Hennig, Olivier Corneloup, Michel Montaudon, François Laurent, Hubert Cochet, Bara Erhayiem, Adam K. McDiarmid, Pankaj Garg, Laura E. Dobson, Tarique A. Musa, David Ripley, Ramzi Ajjan, John P. Greenwood, Sven Plein, Peter P. Swoboda, Georg Fuernau, Charlotte Eitel, Suzanne de Waha, Steffen Desch, Gerhard Schuler, Holger Thiele, Ingo Eitel, A. Cadoni, C. D'andrea, S. Costa, P. Keilberg, A. Lunardini, GD. Aquaro, G. Peritore, F. Ricci, D. De Marchi, C. Passino, J. Navarro Cuartero, J.G. Córdoba Soriano, S. Calero Núñez, T. Cros Ruiz de Galarreta, M. Villar García, J.C. Gallego Page, J.C. García López, M. Barambio Ruiz, Jonathan C. Rodrigues, Bethannie McIntyre, Amy E. Burchell, Laura Ratcliffe, Emma C. Hart, Julian F. Paton, Angus K. Nightingale, Nathan E. Manghat, Takashi Tanimoto, Shingo Ota, Tsuyoshi Nishiguchi, Hiroto Tsujioka, Akio Kuroi, Takashi Yamano, Yoshiki Matsuo, Yasushi Ino, Hironori Kitabata, Takashi Kubo, Atsushi Tanaka, Takeshi Hozumi, Takashi Akasaka, Teresa Pinho, Paulo Canedo, Luís Lopes, Olga Azevedo, António Madureira, Adriana Belo, José Silva Cardoso, José Carlos Machado, Elisabete Martins, Andrzej Urbanik, Tomasz Rakowski, E. Pozo-Osinalde, D. Viliani, MJ. Olivera, P. Caballero, LJ. Jiménez-Borreguero, F. Alfonso, Giulia Angeloni, Angela Migliorini, Renato Valenti, Guido Parodi, David Antoniucci, Ana Galrinho, Luísa Moura-Branco, Nuno Tavares-Jalles, Marta António, João Abreu, Ana Teresa Timóteo, Pedro Pinto-Teixeira, Sílvia Aguiar-Rosa, Inês Rodrigues, Pedro Modas-Daniel, Rui Cruz-Ferreira, D. Dobre, S. Stanciu, E. Acatrinei, A. Nour, L. Stefan, P. Calistru, M. Pyda, M. Janus, A. Siniawski, Walid Abdel-Azim Elhammady, Mohamed Ismail Ahmed, Ahmed Samir Abdel-Hakim, Lamyaa Elsayed Allam, Ayman Mohamed Helal, Naokazu Mizuno, Gladys JUNCÀ, Javier ARCE, David ARMARIO, Damien Logeart, Barnabas Gelen, Genevie`ve Derumeaux, Eric Vicaut, Jean-Jacques Mercadier, Marc Sirol, Manuel De Lazzari, Angela Susana, Alessandro Zorzi, Anna Baritussio, Mariachiara Siciliano, Martina Marinato, Francesca Prevedello, Benedetta Giorgi, Roberto Vezzaro, Domenico Corrado, Martina Perazzolo Marra, K.-P. Rommel, J.T. Kowallick, S. Blazek, K. Fengler, J. Lotz, G. Hasenfuß, Ch. Lücke, M. Gutberlet, G. Schuler, A. Schuster, Ph. Lurz, Osama Rifaie, Ahmed Samir, Lamyaa Allam, Caroline Zotter-Tufaro, Stefan Aschauer, Diana Bonderman, Julia Mascherbauer, Arno A.W. Roest, Pieter J. van den Boogaard, Emmeline E. Calkoen, Rob J. van der Geest, Mark G. Hazekamp, Albert de Roos, Jos J.M. Westenberg, C.J. Kellenberger, J. Geiger, B. Ruecker, E.R. Valsangiacomo Buechel, J.R.J. Foley, G. Fent, T.A. Musa, L. Dobson, P.P. Swoboda, J.P. Greenwood, Amy Burchell, Laura Ratcliffe BSc(Hons), Emma Hart, Adrian Monserrat, Alicia Maceira gonzalez, Luis Tuset, Vicente Miro, Amparo Hernandiz, Rubén Fernandez, Asunción Sauri, Pilar Sepúlveda, Jose Luis Diez, Anastasio Montero, Massimo Imbriaco, Gianmarco Alcidi, Andrea Ponsiglione, Ciro Santoro, Marta Puglia, Luigi Barbuto, Alberto Cuocolo, Bruno Trimarco, Maurizio Galderisi, Elena Sanchez, Diego Plaza, Pilar Sepúlveda sanchis, Alicia Maceira Gonzalez, Alex vazquez, Luis Martinez, Hernandez Caballero Alfredo, Domingo Valero Diana, Maceira Gonzalez Alicia, Estornell Erill Jordi, Valera martinez Francisco Jose, Vazquez Sanchez Alejandro, Montero Argudo Anastasio, T.A. Shelkovnikova, S.V. Popov, P.I. Lukyanenok, A.A. Shelupanov, A.I. Oferkin, T.A. Bakhmet'eva, W.Yu. Ussov, Jos JM. Westenberg, Wikke Setz-Pels, Erik Kersten, Alexander Tielbeek, Lucien EM. Duijm, Johannes Post, Joep A.W. Teijink, A. Kirschfink, E. Mühler, N. Marx, H. Hövels-Gürich, Feistritzer Hans-Josef, Reinstadler Sebastian, Reindl Martin, Seidner Benjamin, Mayr Agnes, Müller Sylvana, Metzler Bernhard, aMamdouh Zidan, Ondrej Holub, Rachel Clough, Gerald Carr-White, Reza Razavi, Ralph Sinkus, E.E. Bobrikova, I.L. Bukhovets, M.P. Plotnikov, Yu.V. Rogovskaya, M.S. Rebenkova, W.Yu. Usov, Christian Kremser, Michael Schocke, F.R. Pluchinotta, G. Giusti, F. Secchi, L. Piazza, M. Carminati, M. Chessa, J.P. Bokma, B.J. Bouma, B.J. Mulder, M. Lombardi, Treibel Thomas, Kozor Rebecca, Bulluck Heeraj, Moon James, Manisty Charlotte, Fabienne Bertron, Sueheyla Oezkan, Dirk Lossnitzer, Stefan O. Schoenberg, Martin Borggrefe, Christina Doesch, NC. Edwards, B. Liu, MK. Hayer, CH. Dawson, T. Geberhiwot, RP. Steeds, H. Stern, N. Mkrtchyan, C. Meierhofer, S. Martinoff, P. Ewert, S. Fratz, Bruno Piçarra, Ana Rita Santos, Rui Guerreiro, Kisa Hyde Congo, João Carvalho, David Neves, José Aguiar, Kady Fischer, Chantal Labelle, Sylvie Gelineau, Sandra Farkas, Julie Lebel, Matthias G. Friedrich, Adriana Villa, Imane Bekri, Joy Shome, Tom Teall, Gabriella Di Giovine, Eva Sammut, Khaled Al-Fakih, Amedeo Chiribiri, Arno AW. Roest, Lucia JM. Kroft, Nico A. Blom, Mohammed SM. Elbaz, A. Soufiani, H. Barahioui, A. Bayi, N. Fellat, H. Benjelloun, Z. Tazi, A. Uddin, PP. Swoboa, CJ. Malkin, DJ. Blackman, Hiram G. Bezerra, Maria Rita Gamberini, Maria Giovanna Neri, Liana Cuccia, Domenico Giuseppe D'Ascola, Chiara Tudisca, Valentina Vinci, Vincenzo Positano, Alessia Pepe, Caterina Borgna-Pignatti, Giovanni Carlo Del Vecchio, Maria Antonietta Romeo, Federico Bonetti, Massimiliano Missere, Cristina Salvatori, TA. Fairbairn, OJ. Bebb, J. Foley, J. Eckert, M. Tröbs, A. Magedanz, M. Schmidt, T. Voigtländer, A. Schmermund, S. Achenbach, GF. Fent, J. Weir McCall, S.J. Gandy, W.G. Milne, J.G Houston, P. Ricchi, A. Spasiano, MG. Neri, A. Vallone, MC. Resta, R. Righi, V. Santamaria, V. Positano, A. Pepe, Tarek Bengrid, Rachel Nicoll, Ying Zhao, Bengt Johansson, Axel Schmermund, Irene Cascone, Eligio Miccichè, Sergio Buccheri, Sebastiano Immè, Gerlando Pilato, Claudia Tamburino, Martina Patanè, Simona Gulino, Denise Todaro, Tatiana Salerno, Valeria Garretto, Gianbattista Privitera, Davide Capodanno, Corrado Tamburino, Alessio La Manna, Pier-Giorgio Masci, Tobias Rutz, Jonathan De Blois, Juerg Schwitter, Pierre Monney, Tom Vandendriessche, Dina De Bock, Paul M. Parizel, Inez E. Rodrigus, Marc J. Claeys, F. Tosello, G. Bruno, E. Avenatti, R. Faletti, A Ravera, F. Veglio, A. Milan, A. Maggio, F. Leto, L. Pitrolo, A. Terrizzi, M. Serra, M. Allò, G. Di Bella, C. Zito, Neil J. Stewart, Charlotte Hammerton, David Capener, Valentina O Puntmann, Martin J. Graves, David G. Kiely, Jim M. Wild, Andrew J. Swift, A. Barison, N. Salvatore, P. Assennato, Beatrice A. Marzluf, Klaus Knechtelsdorfer, Matthias Wiesinger, Daniel Dalos, Stefan Pfaffenberger, Maciej Sosnowski, Zbigniew Gąsior, Ismail El-Hamamsy, François-Pierre Mongeon SM, Jan Eritsland, Limalanathan Shanmuganathan, Mikael Abdelnoor, Geir Øystein Andersen, Nils Einar Kløw, Pavel Hoffmann, Jérôme Caudron, Christophe Tron, Carlos Rodriguez Camacho, Alain Cribier, Jean Nicolas Dacher, Hélène Eltchaninoff, Geeta Gulati, Florian Von Knobelsdorff-Brenkenhoff, Tryggve Holck Storås, Jeanette Schulz-Menger, Torbjørn Omland, J. Traber, W. Utz, P. Hennig, M. Menza, B. Jung, A. Greiser, J. Kuijer, P. Barckow, A. Töpper, J Schulz-Menger, Sara Moscatelli, Luca Balzarini, Maria Pia Del Corral, Gabriele Gasparini, Orsola Montini, Lorenzo Monti, Alessandra Briatico, Patrizia Toia, Lamia Ait-Ali, Massimo Midiri, Antonio Raffaele Cotroneo, Pierluigi Festa, G. Todiere, C. 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Casas, Francesca Pluchinotta, Amardeep Dastidar, Ben Littlejohns, Saadeh Suleiman, Andreas Baumbach, Vincenzo Vizzi, Yves Fierens, Jan Nijs, Johan De Mey, Peng Lai, Hubert Raeymaekers, Johannes Toger, Einar Heiberg, Jos J. Westenberg, Fatih Hafalir, Piero Ghedin, A. Shimakawa, C. Anja, Pedro Ferreira, Andrew D Scott, Sonia Nielles-Vallespin, Archontis Giannakidis, Philip J Kilner, Peter D Gatehouse, Ranil de Silva, David N Firmin, Dudley J Pennell, Hans-Wilko Beurich, Dirk Zachow, Mohamed El-Mawardy, Mohamed Abdel-Wahab, Gert Richardt, Ralph Tölg, Giovanni Biglino, Wilson Aileen, James Dodd, A. González Gómez, C. Fernández Golfín, A. Marco del Castillo, J. Monteagudo, M. Pascual Izco, A. Megías, A. García Martín, JJ. Jiménez Nacher, JL Zamorano, Alexander Carpenter, Alberto Palazzuoli, Catherine Wilson, Samantha Kestenbaum, Gergely Szantho, Chris Benny Lawton, Abhishek Shetye, Jamal N. Khan, Prathap Kanagala, Daniel Swarbrick, Gaurav Gulsin, Matthew Graham-Brown, Anthony Gershlick, Gerry P. McCann

Publikováno v: European Heart Journal – Cardiovascular Imaging. 17:i37-i84

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d746826f75966a979f89db16d295d965
https://doi.org/10.1093/ehjci/jew183

Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit

Autor: Christina Mallarino Haeger, Sara O. Vargas, Rajeev Saggar, Stephen M. Black, Thomas Bertero, Sohrab Fratz, Laura E. Fredenburgh, Kathleen J. Haley, Stephen Y. Chan, Paul B. Dieffenbach, Brian B. Graham, David J. Ross, Yu Lu, W. Dean Wallace, Vivek Kaimal, Sofia Annis, Katherine A. Cottrill, B. Nelson Chau, Jeffrey R. Fineman, Rajesh Kumar, Rajan Saggar, Andrew E. Hale, Balkrishen Bhat, Aaron B. Waxman, Ying Yi Zhang

Publikováno v: Cell Reports, Vol 13, Iss 5, Pp 1016-1032 (2015)
Cell reports, vol 13, iss 5

SummaryPulmonary hypertension (PH) is a deadly vascular disease with enigmatic molecular origins. We found that vascular extracellular matrix (ECM) remodeling and stiffening are early and pervasive processes that promote PH. In multiple pulmonary vas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe6176813c190190c9b5852f91ac48c
http://www.sciencedirect.com/science/article/pii/S2211124715010748

Da Silva's cone repair for Ebstein's anomaly: effect on right ventricular size and function

Autor: Andreas Kühn, Melchior Burri, Lena Eschenbach, Sohrab Fratz, Rüdiger Lange, CC Badiu, José Pedro da Silva, Jürgen Hörer, Manfred Vogt, Nicole Nagdyman, Christian Schreiber

Publikováno v: European Journal of Cardio-Thoracic Surgery. 48:316-321

OBJECTIVES Da Silva's cone repair is a novel technique for surgical reconstruction of the tricuspid valve and the right ventricle (RV) in Ebstein's anomaly. The technique consists of extensive leaflet mobilization, longitudinal plication of the atria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a21ffa4b3eb871c7b48e916dc66f982
https://doi.org/10.1093/ejcts/ezu472