Crystal structure of the anti-(carcinoembryonic antigen) single-chain Fv antibody MFE-23 and a model for antigen binding based on intermolecular contacts

Autor: Boehm, M K, Corper, A L, Wan, T, Sohi, M K, Sutton, B J, Thornton, J D, Keep, P A, Chester, K A, Begent, R H, Perkins, S J

MFE-23 is the first single-chain Fv antibody molecule to be used in patients and is used to target colorectal cancer through its high affinity for carcinoembryonic antigen (CEA), a cell-surface member of the immunoglobulin superfamily. MFE-23 contain

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https://europepmc.org/articles/PMC1220881/

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Crystal structure of the anti-(carcinoembryonic antigen) single-chain Fv antibody MFE-23 and a model for antigen binding based on intermolecular contacts.

Autor: Boehm MK; Department of Biochemistry and Molecular Biology, Royal Free Campus, Royal Free and University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK., Corper AL, Wan T, Sohi MK, Sutton BJ, Thornton JD, Keep PA, Chester KA, Begent RH, Perkins SJ

Publikováno v: The Biochemical journal [Biochem J] 2000 Mar 01; Vol. 346 Pt 2, pp. 519-28.

Crystal structure of the zinc-dependent beta-lactamase from Bacillus cereus at 1.9 A resolution: binuclear active site with features of a mononuclear enzyme.

Autor: Fabiane SM; The Randall Institute, King's College London, U.K., Sohi MK, Wan T, Payne DJ, Bateson JH, Mitchell T, Sutton BJ

Publikováno v: Biochemistry [Biochemistry] 1998 Sep 08; Vol. 37 (36), pp. 12404-11.

Purification and crystallisation of the autoantigen thyroid peroxidase from human Graves' thyroid tissue.

Autor: Gardas A; Medical Centre of Postgraduate Education, Warsaw, Poland., Sohi MK, Sutton BJ, McGregor AM, Banga JP

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1997 May 19; Vol. 234 (2), pp. 366-70.