Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders.

Autor: Shin D; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA., Kim CN; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA., Ross J; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA., Hennick KM; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA., Wu SR; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA., Paranjape N; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94107, USA., Leonard R; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA., Wang JC; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA., Keefe MG; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA., Pavlovic BJ; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA., Donohue KC; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94158, USA., Moreau C; Sainte Justine Research Center, University of Montréal, 3175 Chemin de la Côte-Sainte-Catherine, Montréal, QC H3T 1C5, Canada; Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Wigdor EM; Institute of Developmental and Regenerative Medicine, University of Oxford, Headington, Oxford OX3 7TY, UK., Larson HH; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA., Allen DE; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA., Cadwell CR; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA., Bhaduri A; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA., Popova G; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA., Bearden CE; Integrative Center for Neurogenetics, Semel Institute for Neuroscience and Human Behavior, Departments of Psychiatry and Biobehavioral Sciences and Psychology, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90095, USA., Pollen AA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA., Jacquemont S; Sainte Justine Research Center, University of Montréal, 3175 Chemin de la Côte-Sainte-Catherine, Montréal, QC H3T 1C5, Canada., Sanders SJ; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94158, USA; Institute of Developmental and Regenerative Medicine, University of Oxford, Headington, Oxford OX3 7TY, UK., Haussler D; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95060, USA; Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Howard Hughes Medical Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA., Wiita AP; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94107, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158., Frost NA; Department of Neurology, University of Utah, Salt Lake City, UT 84108, USA., Sohal VS; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94158, USA., Nowakowski TJ; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: tomasz.nowakowski@ucsf.edu.

Publikováno v: Cell stem cell [Cell Stem Cell] 2024 Mar 07; Vol. 31 (3), pp. 421-432.e8. Date of Electronic Publication: 2024 Feb 20.

Tsc1 Loss in VIP-Lineage Cortical Interneurons Results in More VIP+ Interneurons and Enhanced Excitability.

Autor: Hu JS; Department of Psychiatry, University of California San Francisco, San Francisco, CA 94158, USA., Malik R; Department of Psychiatry, University of California San Francisco, San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA.; Center for Integrative Neuroscience, University of California San Francisco, 1550 4th St., San Francisco, CA 94158, USA.; Sloan-Swartz Center for Theoretical Neurobiology, University of California San Francisco, 1550 4th St., San Francisco, CA 94158, USA., Sohal VS; Department of Psychiatry, University of California San Francisco, San Francisco, CA 94158, USA.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158, USA.; Center for Integrative Neuroscience, University of California San Francisco, 1550 4th St., San Francisco, CA 94158, USA.; Sloan-Swartz Center for Theoretical Neurobiology, University of California San Francisco, 1550 4th St., San Francisco, CA 94158, USA., Rubenstein JL; Department of Psychiatry, University of California San Francisco, San Francisco, CA 94158, USA., Vogt D; Department of Pediatrics and Human Development, Michigan State University, Grand Rapids, MI 49503, USA.; Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA.

Publikováno v: Cells [Cells] 2023 Dec 26; Vol. 13 (1). Date of Electronic Publication: 2023 Dec 26.

Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders.

Autor: Sohal VS; Department of Psychiatry, Weill Institute for Neurosciences, and Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, CA, 94143, USA. vikaas.sohal@ucsf.edu., Rubenstein JLR; Department of Psychiatry, Weill Institute for Neurosciences, and Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, CA, 94143, USA. John.Rubenstein@ucsf.edu.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2019 Sep; Vol. 24 (9), pp. 1248-1257. Date of Electronic Publication: 2019 May 14.

Fate mapping of neural stem cell niches reveals distinct origins of human cortical astrocytes.

Autor: Allen DE; Department of Anatomy, University of California, San Francisco, CA, USA.; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.; Department of Neurological Surgery, University of California, San Francisco, CA, USA.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA., Donohue KC; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.; School of Medicine, University of California, San Francisco, CA, USA.; Center for Integrative Neuroscience, University of California, San Francisco, CA, USA.; Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, CA, USA., Cadwell CR; Department of Pathology, University of California, San Francisco, CA, USA., Shin D; Department of Anatomy, University of California, San Francisco, CA, USA.; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.; Department of Neurological Surgery, University of California, San Francisco, CA, USA.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA., Keefe MG; Department of Anatomy, University of California, San Francisco, CA, USA.; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.; Department of Neurological Surgery, University of California, San Francisco, CA, USA.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA., Sohal VS; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.; Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, CA, USA., Nowakowski TJ; Department of Anatomy, University of California, San Francisco, CA, USA.; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.; Department of Neurological Surgery, University of California, San Francisco, CA, USA.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.; Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2022 Jun 24; Vol. 376 (6600), pp. 1441-1446. Date of Electronic Publication: 2022 May 19.

Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition.

Autor: Malik R; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, CA, USA., Li Y; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, CA, USA., Schamiloglu S; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, CA, USA., Sohal VS; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, CA, USA. Electronic address: vikaas.sohal@ucsf.edu.

Publikováno v: Cell [Cell] 2022 Apr 28; Vol. 185 (9), pp. 1602-1617.e17.