Studying the effect of silver nanoparticles synthesized by ulva fasciata aqueous extract against liver toxicity induced by CCl4in rats

Autor: Fawzia A Alshubaily, Ebtihaj J Jambi, Sohair M Khojah, Maha J Balgoon, Maryam H Al-Zahrani, Nuha A Alkhattabi

Publikováno v: Journal of Nature and Science of Medicine, Vol 3, Iss 3, Pp 182-188 (2020)

Background: Researchers in recent years have been increasingly concerned with the production of synthesizing nanoparticles (NPs) applying plant extracts, as these NPs have low environmental risk and low human toxicity. The present study aimed to use

Externí odkaz: https://doaj.org/article/e7e84f118e9a41a3a224c6fb3e716276

Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities

Autor: Maiy Y. Jaballah, Rabah A. T. Serya, Nasser Saad, Sohair M. Khojah, Marawan Ahmed, Khaled Barakat, Khaled A. M. Abouzid

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1573-1589 (2019)

Pyridazine scaffolds are considered privileged structures pertaining to its novelty, chemical stability, and synthetic feasibility. In our quest towards the development of novel scaffolds for effective vascular endothelial growth 2 (VEGFR-2) inhibiti

Externí odkaz: https://doaj.org/article/27813414469e43d5984e073d2be6138d

Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition

Autor: Asmaa M. AboulMagd, Tamer M. Abdelghany, Salwa Elmeligie, Sohair M Khojah, Khaled A.M. Abouzid, Tamer M. Ibrahim, Deena S. Lasheen

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1347-1367 (2019)

In the designed compounds, either a biarylamide or biarylurea moiety or an N-substituted piperazine motif was linked to position 1 of the phthalazine core. The anti-proliferative activity of the synthesised compounds revealed that eight compounds (6b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ca860537b28c27ab5de8ccb33345d9
https://doi.org/10.1080/14756366.2019.1642883

Design and Synthesis of New Quinoxaline Derivatives as Anticancer Agents and Apoptotic Inducers

Autor: Khaled A.M. Abouzid, Sohair M Khojah, Nasser S.M. Ismail, Dalal A. Abou El Ella, Yassin M. Nissan, Aliya M. S. El Newahie

Publikováno v: Molecules
Volume 24
Issue 6
Molecules, Vol 24, Iss 6, p 1175 (2019)

The quinoxaline scaffold is a promising platform for the discovery of active chemotherapeutic agents. Three series of quinoxaline derivatives were synthesized and biologically evaluated against three tumor cell lines (HCT116 human colon carcinoma, He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38f22012d3e84bbb450f61edcf8649e

Design and Synthesis of New Quinoxaline Derivatives as Anticancer Agents and Apoptotic Inducers

Autor: Aliya M. S. El Newahie, Yassin M. Nissan, Nasser S. M. Ismail, Dalal A. Abou El Ella, Sohair M. Khojah, Khaled A.M. Abouzid

Publikováno v: Molecules, Vol 24, Iss 6, p 1175 (2019)

The quinoxaline scaffold is a promising platform for the discovery of active chemotherapeutic agents. Three series of quinoxaline derivatives were synthesized and biologically evaluated against three tumor cell lines (HCT116 human colon carcinoma, He

Externí odkaz: https://doaj.org/article/57a8f786f960428fa7e2ea32e0f87e0f