Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Soh-hyun Lee"'
Autor:
Arevik Ghazaryan, Jared A. Wallace, William W. Tang, Cindy Barba, Soh-Hyun Lee, Kaylyn M. Bauer, Morgan C. Nelson, Carissa N. Kim, Chris Stubben, Warren P. Voth, Dinesh S. Rao, Ryan M. O’Connell
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Acute myeloid leukemia (AML) is a heterogeneous and deadly disease characterized by uncontrolled expansion of malignant blasts. Altered metabolism and dysregulated microRNA (miRNA) expression profiles are both characteristic of AML. However, there is
Externí odkaz:
https://doaj.org/article/7398a18c853e402d9edaebb274d37ba5
Autor:
Kaylyn M. Bauer, Morgan C. Nelson, William W. Tang, Tyson R. Chiaro, D. Garrett Brown, Arevik Ghazaryan, Soh-Hyun Lee, Allison M. Weis, Jennifer H. Hill, Kendra A. Klag, Van B. Tran, Jacob W. Thompson, Andrew G. Ramstead, Josh K. Monts, James E. Marvin, Margaret Alexander, Warren P. Voth, W. Zac Stephens, Diane M. Ward, Aaron C. Petrey, June L. Round, Ryan M. O’Connell
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Intercellular communication is critical for homeostasis in mammalian systems, including the gastrointestinal (GI) tract. Exosomes are nanoscale lipid extracellular vesicles that mediate communication between many cell types. Notably, the roles of imm
Externí odkaz:
https://doaj.org/article/28e27534285f41e8b7743abd9a89a3a7
Autor:
Thomas B. Huffaker, H. Atakan Ekiz, Cindy Barba, Soh-Hyun Lee, Marah C. Runtsch, Morgan C. Nelson, Kaylyn M. Bauer, William W. Tang, Timothy L. Mosbruger, James E. Cox, June L. Round, Warren P. Voth, Ryan M. O’Connell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
IFNy can polarize macrophages in the tumour microenvironment to an inflammatory state and thereby contributes to their anti-tumour function. Here the authors show an underlying mechanism in this process is IFNy-driven STAT1 occupancy and activation o
Externí odkaz:
https://doaj.org/article/b194e57208eb4a39a01b6f84ed5db4cc
Autor:
Andrew G. Ramstead, Jared A. Wallace, Soh-Hyun Lee, Kaylyn M. Bauer, William W. Tang, H. Atakan Ekiz, Thomas E. Lane, Ahmad A. Cluntun, Matthew L. Bettini, June L. Round, Jared Rutter, Ryan M. O’Connell
Publikováno v:
Cell Reports, Vol 30, Iss 9, Pp 2889-2899.e6 (2020)
Summary: Metabolic pathways regulate T cell development and function, but many remain understudied. Recently, the mitochondrial pyruvate carrier (MPC) was identified as the transporter that mediates pyruvate entry into mitochondria, promoting pyruvat
Externí odkaz:
https://doaj.org/article/85eca401df46476092567316c9937106
Autor:
Marah C Runtsch, Morgan C Nelson, Soh-Hyun Lee, Warren Voth, Margaret Alexander, Ruozhen Hu, Jared Wallace, Charisse Petersen, Vanja Panic, Claudio J Villanueva, Kimberley J Evason, Kaylyn M Bauer, Timothy Mosbruger, Sihem Boudina, Mary Bronner, June L Round, Micah J Drummond, Ryan M O'Connell
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007970 (2019)
Identifying regulatory mechanisms that influence inflammation in metabolic tissues is critical for developing novel metabolic disease treatments. Here, we investigated the role of microRNA-146a (miR-146a) during diet-induced obesity in mice. miR-146a
Externí odkaz:
https://doaj.org/article/0b801b0c45b84c1488fd88a3d64a9028
Autor:
Lipika Salaye, Ielizaveta Bychkova, Sandy Sink, Alexander J. Kovalic, Manish S. Bharadwaj, Felipe Lorenzo, Shalini Jain, Alexandria V. Harrison, Ashley T. Davis, Katherine Turnbull, Nuwan T. Meegalla, Soh-hyun Lee, Robert Cooksey, George L. Donati, Kylie Kavanagh, Herbert L. Bonkovsky, Donald A. McClain
Publikováno v:
Nutrients, Vol 11, Iss 9, p 2172 (2019)
High tissue iron levels are a risk factor for multiple chronic diseases including type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD). To investigate causal relationships and underlying mechanisms, we used an established NAF
Externí odkaz:
https://doaj.org/article/14889f3ad3f042879777322d65b454f8
Autor:
Cindy Barba, H. Atakan Ekiz, William Weihao Tang, Arevik Ghazaryan, Mason Hansen, Soh-Hyun Lee, Warren Peter Voth, Ryan Michael O’Connell
Publikováno v:
Cancers
Volume 15
Issue 5
Pages: 1411
Volume 15
Issue 5
Pages: 1411
(1) Background: Immune cells infiltrate the tumor microenvironment and secrete inflammatory cytokines, including interferons (IFNs), to drive antitumor responses and promote tumor clearance. However, recent evidence suggests that sometimes, tumor cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24dc074fa91c9449fa3075a5fba6c1d0
Autor:
Ghazaryan, Arevik, Wallace, Jared A., Tang, William W., Barba, Cindy, Soh-Hyun Lee, Bauer, Kaylyn M., Nelson, Morgan C., Kim, Carissa N., Stubben, Chris, Voth, Warren P., Rao, Dinesh S., O'Connell, Ryan M.
Publikováno v:
Frontiers in Genetics; 2023, p1-12, 12p
Autor:
Jared Wallace, Ryan M. O'Connell, H. Atakan Ekiz, Dinesh S. Rao, Soh-Hyun Lee, Micah J. Drummond, Morgan C. Nelson, June L. Round, Ruozhen Hu, Andrew G. Ramstead, Kaylyn M. Bauer, Jared Rutter
Publikováno v:
J Immunol
Aging-related chronic inflammation is a risk factor for many human disorders through incompletely understood mechanisms. Aged mice deficient in microRNA (miRNA/miR)-146a succumb to life-shortening chronic inflammation. In this study, we report that m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df68690f80804187c37fda9d4cb2410
https://doi.org/10.4049/jimmunol.1901484
https://doi.org/10.4049/jimmunol.1901484
Autor:
Marah C. Runtsch, Soh-Hyun Lee, H. Atakan Ekiz, Ryan M. O'Connell, Thomas B. Huffaker, Timothy L. Mosbruger, Kaylyn M. Bauer, Warren P. Voth, Morgan C. Nelson, June L. Round, Cindy Barba, William W. Tang, James E. Cox
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Tumor associated macrophage responses are regulated by distinct metabolic states that affect their function. However, the ability of specific signals in the local tumor microenvironment to program macrophage metabolism remains under investigation. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefb49672322d5c2aa94107b0824f78c
https://pubmed.ncbi.nlm.nih.gov/33976173
https://pubmed.ncbi.nlm.nih.gov/33976173