Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Sofya V, Lushchekina"'
Autor:
Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Sofya V. Lushchekina, Tatiana Yu Astakhova, Elena N. Timokhina, Olga G. Serebryakova, Alexander V. Shchepochkin, Maxim A. Averkov, Irina A. Utepova, Nadezhda S. Demina, Eugene V. Radchenko, Vladimir A. Palyulin, Vladimir P. Fisenko, Sergey O. Bachurin, Oleg N. Chupakhin, Valery N. Charushin, Rudy J. Richardson
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
We investigated the inhibitory activities of novel 9-phosphoryl-9,10-dihydroacridines and 9-phosphorylacridines against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carboxylesterase (CES). We also studied the abilities of the new co
Externí odkaz:
https://doaj.org/article/19995bc7cc79494d8334518aebc4070e
Autor:
Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Sofya V. Lushchekina, Tatiana Y. Astakhova, Elena N. Timokhina, Igor V. Serkov, Alexey N. Proshin, Yuliya V. Soldatova, Darya A. Poletaeva, Irina I. Faingold, Viktoriya A. Mumyatova, Alexey A. Terentiev, Eugene V. Radchenko, Vladimir A. Palyulin, Sergey O. Bachurin, Rudy J. Richardson
Publikováno v:
Molecules, Vol 29, Iss 2, p 321 (2024)
Effective therapeutics for Alzheimer’s disease (AD) are in great demand worldwide. In our previous work, we responded to this need by synthesizing novel drug candidates consisting of 4-amino-2,3-polymethylenequinolines conjugated with butylated hyd
Externí odkaz:
https://doaj.org/article/9dc8029bd61a4fcb9dc34956137feaf5
Autor:
Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Maria V. Grishchenko, Sofya V. Lushchekina, Tatiana Y. Astakhova, Olga G. Serebryakova, Elena N. Timokhina, Ekaterina F. Zhilina, Evgeny V. Shchegolkov, Mariya V. Ulitko, Eugene V. Radchenko, Vladimir A. Palyulin, Yanina V. Burgart, Victor I. Saloutin, Sergey O. Bachurin, Rudy J. Richardson
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2285 (2023)
A series of previously synthesized conjugates of tacrine and salicylamide was extended by varying the structure of the salicylamide fragment and using salicylic aldehyde to synthesize salicylimine derivatives. The hybrids exhibited broad-spectrum bio
Externí odkaz:
https://doaj.org/article/7e0b27a3aeb244eeb22116b3b545edc1
Autor:
Sergey O. Bachurin, Elena F. Shevtsova, Galina F. Makhaeva, Alexey Yu. Aksinenko, Vladimir V. Grigoriev, Tatiana V. Goreva, Tatiana A. Epishina, Nadezhda V. Kovaleva, Natalia P. Boltneva, Sofya V. Lushchekina, Elena V. Rudakova, Darya V. Vinogradova, Pavel N. Shevtsov, Elena A. Pushkareva, Ludmila G. Dubova, Tatiana P. Serkova, Ivan M. Veselov, Vladimir P. Fisenko, Rudy J. Richardson
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13925 (2022)
The development of multi-target-directed ligands (MTDLs) would provide effective therapy of neurodegenerative diseases (ND) with complex and nonclear pathogenesis. A promising method to create such potential drugs is combining neuroactive pharmacopho
Externí odkaz:
https://doaj.org/article/bed9b9696c514d1caf241d2b10e8865d
Autor:
Vyacheslav E. Semenov, Irina V. Zueva, Sofya V. Lushchekina, Eduard G. Suleimanov, Liliya M. Gubaidullina, Marina M. Shulaeva, Oksana A. Lenina, Konstantin A. Petrov
Publikováno v:
Molecules, Vol 27, Iss 22, p 7855 (2022)
Novel derivatives based on 6-methyluracil and condensed uracil, 2,4-quinazoline-2,4-dione, were synthesized with terminal meta- and para-benzoate moieties in polymethylene chains at the N atoms of the pyrimidine ring. In the synthesized compounds, th
Externí odkaz:
https://doaj.org/article/76c4a99ab68949beb4f66f6db588bdb1
Autor:
Natalia A. Elkina, Maria V. Grishchenko, Evgeny V. Shchegolkov, Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Sofya V. Lushchekina, Tatiana Y. Astakhova, Eugene V. Radchenko, Vladimir A. Palyulin, Ekaterina F. Zhilina, Anastasiya N. Perminova, Luka S. Lapshin, Yanina V. Burgart, Victor I. Saloutin, Rudy J. Richardson
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1551 (2022)
Alzheimer’s disease (AD) is considered a modern epidemic because of its increasing prevalence worldwide and serious medico-social consequences, including the economic burden of treatment and patient care. The development of new effective therapeuti
Externí odkaz:
https://doaj.org/article/407988391fe84cfd910efe4df0c33cf1
Autor:
Galina F. Makhaeva, Nadezhda V. Kovaleva, Natalia P. Boltneva, Elena V. Rudakova, Sofya V. Lushchekina, Tatiana Yu. Astakhova, Igor V. Serkov, Alexey N. Proshin, Eugene V. Radchenko, Vladimir A. Palyulin, Jan Korabecny, Ondrej Soukup, Sergey O. Bachurin, Rudy J. Richardson
Publikováno v:
Molecules, Vol 27, Iss 3, p 1060 (2022)
Using two ways of functionalizing amiridine—acylation with chloroacetic acid chloride and reaction with thiophosgene—we have synthesized new homobivalent bis-amiridines joined by two different spacers—bis-N-acyl-alkylene (3) and bis-N-thiourea-
Externí odkaz:
https://doaj.org/article/90ae90fd4e9f4057a738309e4978db2b
Autor:
Sergey O. Bachurin, Galina F. Makhaeva, Elena F. Shevtsova, Alexey Yu. Aksinenko, Vladimir V. Grigoriev, Pavel N. Shevtsov, Tatiana V. Goreva, Tatiana A. Epishina, Nadezhda V. Kovaleva, Elena A. Pushkareva, Natalia P. Boltneva, Sofya V. Lushchekina, Alexey V. Gabrelyan, Vladimir L. Zamoyski, Lyudmila G. Dubova, Elena V. Rudakova, Vladimir P. Fisenko, Elena V. Bovina, Rudy J. Richardson
Publikováno v:
Molecules, Vol 26, Iss 18, p 5527 (2021)
A new series of conjugates of aminoadamantane and γ-carboline, which are basic scaffolds of the known neuroactive agents, memantine and dimebon (Latrepirdine) was synthesized and characterized. Conjugates act simultaneously on several biological str
Externí odkaz:
https://doaj.org/article/b4963a08afd643abb60d9c73f498c6f7
Autor:
Konstantin M. Boyko, Timur N. Baymukhametov, Yury M. Chesnokov, Michael Hons, Sofya V. Lushchekina, Alexey V. Lipkin, Vladimir O. Popov, Michail V. Kovalchuk
Publikováno v:
International Journal of Biomedicine, Vol 9, Iss Suppl_1, Pp S14-S15 (2019)
Background: Human plasma butyrylcholinesterase (hBChE, EC 3.1.1.8) is an endogenous bioscavenger that hydrolyzes numerous medicamentous and poisonous esters and scavenges potent organophosphorus nerve agents. Thus, the hBChE can be used to protect ac
Externí odkaz:
https://doaj.org/article/1a510888dc1f4c52882f5f7e2cca0975
Autor:
Sofya V. Lushchekina, Gaetan Inidjel, Nicolas Martinez, Patrick Masson, Marie Trovaslet-Leroy, Florian Nachon, Michael Marek Koza, Tilo Seydel, Judith Peters
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1664 (2020)
The enzyme model, mouse acetylcholinesterase, which exhibits its active site at the bottom of a narrow gorge, was investigated in the presence of different concentrations of sucrose to shed light on the protein and water dynamics in cholinesterases.
Externí odkaz:
https://doaj.org/article/b4e57c4c55a346208e146917c7f97629