Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Sofiya, Milman"'
Autor:
Kejun Ying, José P. Castro, Anastasia V. Shindyapina, Alexander Tyshkovskiy, Mahdi Moqri, Ludger J. E. Goeminne, Sofiya Milman, Zhengdong D. Zhang, Nir Barzilai, Vadim N. Gladyshev
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract While previous studies identified common genetic variants associated with longevity in centenarians, the role of the rare loss-of-function (LOF) mutation burden remains largely unexplored. Here, we investigated the burden of rare LOF mutatio
Externí odkaz:
https://doaj.org/article/5caa0089e32b4109a566c31b600051c0
Autor:
M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Sanish Sathyan, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract The highly polygenic nature of human longevity renders pleiotropy an indispensable feature of its genetic architecture. Leveraging the genetic correlation between aging-related traits (ARTs), we aimed to model the additive variance in lifesp
Externí odkaz:
https://doaj.org/article/e7089311efc14bf3834f43d096b8f9b4
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
Advancing the new field of translational science and developing innovative solutions to overcome translational roadblocks are key priorities of the Clinical and Translational Science Awards (CTSA) Program of the National Center for Advancing Translat
Externí odkaz:
https://doaj.org/article/2660db0dcb6a4c2f91a77a3fec335a54
Autor:
Gabriela T. Gomez, Sanish Sathyan, Jingsha Chen, Myriam Fornage, Pascal Schlosser, Zhongsheng Peng, Jenifer Cordon, Priya Palta, Kevin J. Sullivan, Adrienne Tin, B. Gwen Windham, Rebecca F. Gottesman, Josef Coresh, Nir Barzilai, Sofiya Milman, Joe Verghese, Keenan A. Walker
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 10-10 (2023)
OBJECTIVES/GOALS: Motoric cognitive risk (MCR) is a pre-dementia syndrome characterized by slow gait and subjective cognitive complaints. In the Atherosclerosis Risk in Communities (ARIC) study, we aim to (1) identify plasma proteins and protein modu
Externí odkaz:
https://doaj.org/article/fbdc928e85a849eb9ef49be079ad8157
Autor:
Tobias Fehlmann, Benoit Lehallier, Nicholas Schaum, Oliver Hahn, Mustafa Kahraman, Yongping Li, Nadja Grammes, Lars Geffers, Christina Backes, Rudi Balling, Fabian Kern, Rejko Krüger, Frank Lammert, Nicole Ludwig, Benjamin Meder, Bastian Fromm, Walter Maetzler, Daniela Berg, Kathrin Brockmann, Christian Deuschle, Anna-Katharina von Thaler, Gerhard W. Eschweiler, Sofiya Milman, Nir Barziliai, Matthias Reichert, Tony Wyss-Coray, Eckart Meese, Andreas Keller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Aging is a key risk factor for chronic diseases of the elderly. Here the authors perform large-scale miRNA profiling of blood from individuals of a range of ages and show that common diseases alter the physiological age-related blood microRNA profile
Externí odkaz:
https://doaj.org/article/132c3d783c2f4f77b4984be2f3b3481b
Autor:
Justina L Groeger, Emmeline Ayers, Nir Barzilai, Olivier Beauchet, Michele Callisaya, Maral R. Torossian, Carol Derby, Takehiko Doi, Richard B. Lipton, Sofiya Milman, Sho Nakakubo, Hiroyuki Shimada, Velandai Srikanth, Cuiling Wang, Joe Verghese
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 3, Iss , Pp 100151- (2022)
Background: Inflammation may play a role in Motoric Cognitive Risk (MCR) syndrome, a pre-dementia syndrome comprised of slow gait and cognitive complaints. Our objective was to examine associations of inflammatory biomarkers with MCR. Methods: We exa
Externí odkaz:
https://doaj.org/article/285024fadd2b47cb890ba19597ca9503
Autor:
Seung-Soo Kim, Adam D. Hudgins, Brenda Gonzalez, Sofiya Milman, Nir Barzilai, Jan Vijg, Zhidong Tu, Yousin Suh
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
The rich data from the genome-wide association studies (GWAS) and phenome-wide association studies (PheWAS) offer an unprecedented opportunity to identify the biological underpinnings of age-related disease (ARD) risk and multimorbidity. Surprisingly
Externí odkaz:
https://doaj.org/article/71779d6d6cbd45c3a57de888aa9d604f
Autor:
Sanish Sathyan, Emmeline Ayers, Dristi Adhikari, Tina Gao, Sofiya Milman, Nir Barzilai, Joe Verghese
Publikováno v:
Annals of Neurology. 93:1187-1197
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81bee11c49df6b210327a2f7edf9bcd6
https://doi.org/10.1002/ana.26624
https://doi.org/10.1002/ana.26624
Autor:
Joe Verghese, Emmeline Ayers, Sanish Sathyan, Richard B Lipton, Sofiya Milman, Nir Barzilai, Cuiling Wang
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0253976 (2021)
BackgroundEmerging evidence suggests that there is significant variability in the progression of frailty in aging. We aimed to identify latent subpopulations of frailty trajectories, and examine their clinical and biological correlates.MethodsWe char
Externí odkaz:
https://doaj.org/article/dca223f3ec124f8e8a390f85dd999682
Autor:
Oshadi, Jayakody, Monique, Breslin, Emmeline, Ayers, Joe, Verghese, Nir, Barzilai, Erica, Weiss, Sofiya, Milman, Helena M, Blumen
Publikováno v:
Gait & Posture. 100:8-13
Impairment in gait domains such as pace, rhythm, and variability are associated with falls, cognitive decline, and dementia. However, the longitudinal changes in these gait domains are poorly understood. The aim of this study was to examine age-relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee9084f9db19dc0094918e5444464b8
https://doi.org/10.1016/j.gaitpost.2022.11.009
https://doi.org/10.1016/j.gaitpost.2022.11.009