Výsledky vyhledávání - "Sofija S. Bekić"

Akademický článek

Autor: Sofija S. Bekić, Andrea R. Nikolić, Marija N. Sakač, Edward T. Petri, Anđelka S. Ćelić

Publikováno v: Medical Sciences Forum, Vol 14, Iss 1, p 40 (2022)

The estrogen receptor (ER) is a major therapeutic target in treating estrogen-related diseases, such as breast cancer. There is a need to develop potent ER ligands capable of selectively targeting cancer cells without affecting normal cells. Blocking

Externí odkaz: https://doaj.org/article/40720bb40730441eb6bf1d6580be4a86

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X-ray structure of human aldo–keto reductase 1C3 in complex with a bile acid fused tetrazole inhibitor: experimental validation, molecular docking and structural analysis

Autor: Maja A. Marinović, Sofija S. Bekić, Michael Kugler, Jiří Brynda, Jana Škerlová, Dušan Đ. Škorić, Pavlína Řezáčová, Edward T. Petri, Andjelka S. Ćelić

Publikováno v: RSC Medicinal Chemistry. 14:341-355

Steroid bile acid fused tetrazoles were screened for ability to inhibit aldo–keto reductase 1C3 (AKR1C3), a target for cancer treatment. The X-ray structure of AKR1C3 in complex with a bile acid tetrazole inhibitor is presented.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74b60fe690d2e624282740decf256c7f
https://doi.org/10.1039/d2md00387b

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Antitumor potential of novel 5α,6β-dibromo steroidal D-homo lactone

Autor: Ivana Z. Kuzminac, Sofija S. Bekić, Anđelka S. Ćelić, Dimitar S. Jakimov, Marija N. Sakač

Publikováno v: Steroids. 188

New steroidal D-homo androstane derivative, 5α,6β-dibromo-3β-hydroxy-17-oxa-17a-homoandrostan-16-one was synthesized and its structure was confirmed by NMR spectroscopy. In silico ADME properties of this compound were assessed using the SwissADME

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b427cfe5ffb4ddf022d8dfbcee691b
https://pubmed.ncbi.nlm.nih.gov/36183814

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Hormone receptor binding, selectivity and cytotoxicity of steroid D-homo lactone loaded chitosan nanoparticles for the treatment of breast and prostate cancer cells

Autor: Ivana Z. Kuzminac, Andjelka S. Ćelić, Sofija S. Bekić, Vesna Kojić, Marina P. Savić, Nenad L. Ignjatović

Publikováno v: Colloids and Surfaces B: Biointerfaces

Chemically modified steroids have a long history as anti-neoplastic drugs. Incorporation of a lactone moiety in the steroid nucleus, as in previously obtained 3β-acetoxy-17-oxa-17a-homoandrost-5-en-16-one (A) and 3β-hidroxy-17-oxa-17a-homoandrost-5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8117f79fa2dbce27ac70b4ba78d22847
https://pubmed.ncbi.nlm.nih.gov/35636320

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Investigation of the Potential of Bile Acid Methyl Esters as Inhibitors of Aldo-keto Reductase 1C2: Insight from Molecular Docking, Virtual Screening, Experimental Assays and Molecular Dynamics

Autor: Maja A. Marinović, Edward T. Petri, Ljubica M. Grbović, Bojana R. Vasiljević, Suzana S. Jovanović‐Šanta, Sofija S. Bekić, Andjelka S. Ćelić

Publikováno v: Molecular informaticsReferences. 41(10)

Human aldo-keto reductase 1C isoforms (AKR1C1-C4) catalyze reduction of endogenous and exogenous compounds, including therapeutic drugs, and are associated with chemotherapy resistance. AKR1C2 is involved in metastatic processes and is a target for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89b09966d36d8d571c0caac180efe8f
https://pubmed.ncbi.nlm.nih.gov/35393780

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Microwave-assisted green synthesis of bile acid derivatives and evaluation of glucocorticoid receptor binding

Autor: Sofija S. Bekić, Edward T. Petri, Ljubica Grbović, Bojana Vasiljević, Ksenija Pavlović, Andjelka S. Ćelić

Publikováno v: RSC Med Chem

Herein, we present microwave-assisted AlCl(3) catalyzed oxidation of bile acid hydroxyl groups in the presence of Oxone® in water media. Significant rate enhancements were observed for Wolff–Kishner reduction of synthesized bile acids oxo derivati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a85a3e00ad02ce6fce7b363177eb7257
https://pubmed.ncbi.nlm.nih.gov/34046616

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Evaluation of A-ring fused pyridine d-modified androstane derivatives for antiproliferative and aldo-keto reductase 1C3 inhibitory activity

Autor: Evgenija A. Djurendić, Jovana J. Plavša, Edward T. Petri, Marina P. Savić, Dimitar Jakimov, Olivera R. Klisurić, Andjelka S. Ćelić, Jovana J. Ajduković, Sofija S. Bekić

Publikováno v: RSC Medicinal Chemistry (former MedChemComm). 9(6):969-981

© 2018 The Royal Society of Chemistry. New A-ring pyridine fused androstanes in 17a-homo-17-oxa (d-homo lactone), 17α-picolyl or 17(E)-picolinylidene series were synthesized and validated by X-ray crystallography, HRMS, IR and NMR spectroscopy. Nov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883c368376e45d5c3a13f2aa31232809
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048939069&origin=inward

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Identification of D-seco modified steroid derivatives with affinity for estrogen receptor α and β isoforms using a non-transcriptional fluorescent cell assay in yeast

Autor: Andrea R. Nikolić, Maja A. Marinović, Edward T. Petri, Andjelka S. Ćelić, Vesna Kojić, Sofija S. Bekić, Marija N. Sakač

Publikováno v: Steroids. 130:22-30

Synthesis and biological evaluation of steroidal derivatives with anticancer properties is an active area of drug discovery. Here we measured the relative affinities of d -seco modified steroidal derivatives for estrogen receptor α, estrogen recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f75b3a84da903e4924b09079d1abdf
https://doi.org/10.1016/j.steroids.2017.12.002

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