Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sofie Vandevyver"'
Autor:
Jolien Souffriau, Steven Timmermans, Tineke Vanderhaeghen, Charlotte Wallaeys, Kelly Van Looveren, Lindsy Aelbrecht, Sylviane Dewaele, Jolien Vandewalle, Evy Goossens, Serge Verbanck, Filip Boyen, Melanie Eggermont, Lindsey De Commer, Riet De Rycke, Michiel De Bruyne, Raul Tito, Marlies Ballegeer, Sofie Vandevyver, Tiago Velho, Luis Ferreira Moita, Tino Hochepied, Karolien De Bosscher, Jeroen Raes, Filip Van Immerseel, Rudi Beyaert, Claude Libert
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 10, Pp n/a-n/a (2020)
Abstract The cytokine TNF drives inflammatory diseases, e.g., Crohn's disease. In a mouse model of TNF‐induced systemic inflammatory response syndrome (SIRS), severe impact on intestinal epithelial cells (IECs) is observed. Zinc confers complete pr
Externí odkaz:
https://doaj.org/article/3e993b5bbeaf4e78b2bc46c529806814
Autor:
Ioanna Petta, Nadia Bougarne, Jolien Vandewalle, Lien Dejager, Sofie Vandevyver, Marlies Ballegeer, Sofie Desmet, Jonathan Thommis, Lode De Cauwer, Sam Lievens, Claude Libert, Jan Tavernier, Karolien De Bosscher
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here identify Striatin-3 (STRN3) as a novel interaction partner of GR that interferes with
Externí odkaz:
https://doaj.org/article/77db01aba2e84ce3beeed9e7bccc5c85
Autor:
Sofie Vandevyver, Steven Timmermans, Jorma J. Palvimo, Karen Dendoncker, Jolien Souffriau, Lise Van Wyngene, Melanie Eggermont, Joanna K. Lempiäinen, Ville Paakinaho, Tineke Vanderhaeghen, Claude Libert, Karolien De Bosscher, Marlies Ballegeer, Marc Van Montagu, Evelien Van Hamme, Sylviane Dewaele, Rudi Beyaert, Kelly Van Looveren, Jolien Vandewalle
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(26)
Glucocorticoid resistance (GCR) is defined as an unresponsiveness to the therapeutic effects, including the antiinflammatory ones of glucocorticoids (GCs) and their receptor, the glucocorticoid receptor (GR). It is a problem in the management of infl
Autor:
Riet De Rycke, Jan Tuckermann, Kelly Van Looveren, Roosmarijn E. Vandenbroucke, Fabien Thery, Karolien De Bosscher, Marlies Ballegeer, Francis Impens, Rudi Beyaert, Claude Libert, Holger M. Reichardt, Peter Vandenabeele, Steven Timmermans, Karen Dendoncker, Nozomi Takahashi, Sofie Vandevyver, Jolien Souffriau, Jolien Vandewalle, Lise Van Wyngene, Melanie Eggermont
Publikováno v:
JOURNAL OF CLINICAL INVESTIGATION
TNF is an important mediator in numerous inflammatory diseases, e.g., in inflammatory bowel diseases (IBDs). In IBD, acute increases in TNF production can lead to disease flares. Glucocorticoids (GCs), which are steroids that bind and activate the gl
Autor:
Hamida Hammad, Sofie Vandevyver, F. Van Hauwermeiren, K. De Bosscher, Karen Dendoncker, Johan Grooten, Lien Dejager, Claude Libert, Thomas Naessens, Jolien Souffriau, E. Van Wonterghem, Mieke Eggermont, Monique Willart, Marlies Ballegeer, Bart N. Lambrecht
Publikováno v:
Mucosal Immunology, 8(6), 1212-1225. Nature Publishing Group
Asthma is a heterogeneous disorder, evidenced by distinct types of inflammation resulting in different responsiveness to therapy with glucocorticoids (GCs). Tumor necrosis factor alpha (TNF alpha) is involved in asthma pathogenesis, but anti-TNF alph
Autor:
Lode De Cauwer, Claude Libert, Sam Lievens, Jonathan Thommis, Nadia Bougarne, Jan Tavernier, Marlies Ballegeer, Sofie Desmet, Ioanna Petta, Lien Dejager, Sofie Vandevyver, Karolien De Bosscher, Jolien Vandewalle
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
SCIENTIFIC REPORTS
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
SCIENTIFIC REPORTS
The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here identify Striatin-3 (STRN3) as a novel interaction partner of GR that interferes with GR’s l
Publikováno v:
Cytokine & Growth Factor Reviews. 25:21-33
Pro-inflammatory cytokines are involved in the pathogenesis of many inflammatory diseases, and the excessive expression of many of them is normally counteracted by glucocorticoids (GCs), which are steroids that bind to the glucocorticoid receptor (GR
Publikováno v:
Traffic. 13:364-374
The glucocorticoid receptor (GR) belongs to the superfamily of steroid receptors and is an important regulator of physiological and metabolic processes. In its inactive state, GR is unbound by ligand and resides in the cytoplasm in a chaperone comple
Autor:
Claude Libert, Sofie Vandevyver, G. Schutz, Anna Kleyman, Lien Dejager, Ioanna Petta, David Engblom, Iris Pinheiro, Jan Tuckermann, Tom Van Bogaert, Filip Van Hauwermeiren
Publikováno v:
Journal of Biological Chemistry. 286:26555-26567
As glucocorticoid resistance (GCR) and the concomitant burden pose a worldwide problem, there is an urgent need for a more effective glucocorticoid therapy, for which insights into the molecular mechanisms of GCR are essential. In this study, we addr
Publikováno v:
ENDOCRINE REVIEWS
Glucocorticoids are among the most prescribed drugs worldwide for the treatment of numerous immune and inflammatory disorders. They exert their actions by binding to the glucocorticoid receptor (GR), a member of the nuclear receptor superfamily. Ther