Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Sofie Rutsaert"'
Autor:
Marion Pardons, Basiel Cole, Laurens Lambrechts, Willem van Snippenberg, Sofie Rutsaert, Ytse Noppe, Nele De Langhe, Annemieke Dhondt, Jerel Vega, Filmon Eyassu, Erik Nijs, Ellen Van Gulck, Daniel Boden, Linos Vandekerckhove
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The development of latency reversing agents that potently reactivate HIV without inducing global T cell activation would benefit the field of HIV reservoir research and could pave the way to a functional cure. Here, we explore the reactivati
Externí odkaz:
https://doaj.org/article/3f371f7550f64091855de84f1077f564
Autor:
Zhenhua Zhang, Wim Trypsteen, Marc Blaauw, Xiaojing Chu, Sofie Rutsaert, Linos Vandekerckhove, Wouter van der Heijden, Jéssica Cristina dos Santos, Cheng-Jian Xu, Morris A. Swertz, Andre van der Ven, Yang Li
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-17 (2021)
Abstract Background Combination antiretroviral treatment (cART) cannot eradicate HIV-1 from the body due to the establishment of persisting viral reservoirs which are not affected by therapy and reinitiate new rounds of HIV-1 replication after treatm
Externí odkaz:
https://doaj.org/article/9d335b9fadb540eeb1f023c64679c30e
Autor:
Clarissa Van Hecke, Wim Trypsteen, Eva Malatinkova, Ward De Spiegelaere, Karen Vervisch, Sofie Rutsaert, Sabine Kinloch-de Loes, Magdalena Sips, Linos Vandekerckhove
Publikováno v:
EBioMedicine, Vol 41, Iss , Pp 443-454 (2019)
Background: A wide range of host restriction factors (RF) become upregulated upon HIV-1 infection to suppress viral infectivity and may aid viremic control in vivo. This cross-sectional study evaluated HIV-1 RFs and dependency factors in HIV infected
Externí odkaz:
https://doaj.org/article/1136f58e76a74e148cdf17df17ae635c
Autor:
Sofie Rutsaert, Jean-Marc Steens, Paul Gineste, Basiel Cole, Sam Kint, P. Noel Barrett, Jamal Tazi, Didier Scherrer, Hartmut J. Ehrlich, Linos Vandekerckhove
Publikováno v:
Journal of Virus Eradication, Vol 5, Iss 1, Pp 10-22 (2019)
Objectives: To assess the safety and tolerability as well as antiretroviral impact of ABX464, an oral investigational drug with a novel mechanism of HIV-1 inhibition (ClinicalTrials.gov NCT02735863). Methods: Randomised, double-blind, placebo-control
Externí odkaz:
https://doaj.org/article/3ef3f0db63364cc288365e8f7330998c
Autor:
Lisa Van de Wijer, Wouter A. van der Heijden, Rob ter Horst, Martin Jaeger, Wim Trypsteen, Sofie Rutsaert, Bram van Cranenbroek, Esther van Rijssen, Irma Joosten, Leo Joosten, Linos Vandekerckhove, Till Schoofs, Jan van Lunzen, Mihai G. Netea, Hans J.P.M. Koenen, André J.A.M. van der Ven, Quirijn de Mast
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Long-term changes in the immune system of successfully treated people living with HIV (PLHIV) remain incompletely understood. In this study, we assessed 108 white blood cell (WBC) populations in a cohort of 211 PLHIV on stable antiretroviral therapy
Externí odkaz:
https://doaj.org/article/e9c41e13fb5e4b64bc9b68de40eb9eb4
Autor:
Wouter A. van der Heijden, Lisa Van de Wijer, Farid Keramati, Wim Trypsteen, Sofie Rutsaert, Rob ter Horst, Martin Jaeger, Hans J.P.M. Koenen, Hendrik G. Stunnenberg, Irma Joosten, Paul E. Verweij, Jan van Lunzen, Charles A. Dinarello, Leo A.B. Joosten, Linos Vandekerckhove, Mihai G. Netea, André J.A.M. van der Ven, Quirijn de Mast
Publikováno v:
JCI Insight, Vol 6, Iss 7 (2021)
Chronic inflammation and immune dysfunction play a key role in the development of non-AIDS–related comorbidities. The aim of our study was to characterize the functional phenotype of immune cells in people living with HIV (PLHIV). We enrolled a cro
Externí odkaz:
https://doaj.org/article/b2994f3dd9f54fcfa5fbfca638fec075
Autor:
Philipp Adams, Virginie Fievez, Rafaëla Schober, Mathieu Amand, Gilles Iserentant, Sofie Rutsaert, Géraldine Dessilly, Guido Vanham, Fanny Hedin, Antonio Cosma, Michel Moutschen, Linos Vandekerckhove, Carole Seguin-Devaux
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101881- (2021)
Summary: CD32 has raised conflicting results as a putative marker of the HIV-1 reservoir. We measured CD32 expression in tissues from viremic and virally suppressed humanized mice treated relatively early or late after HIV-1 infection with combined a
Externí odkaz:
https://doaj.org/article/e6ce61d258c04fa48a82f332ec87df33
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-8 (2018)
Abstract Although antiretroviral therapy is able to suppress HIV replication in infected patients, the virus persists and rebounds when treatment is stopped. In order to find a cure that can eradicate the latent reservoir, one must be able to quantif
Externí odkaz:
https://doaj.org/article/cafddd08815343ae9e3bd0ef5c1b5f0d
Autor:
Eva Malatinkova, Jordan Thomas, Ward De Spiegelaere, Sofie Rutsaert, Anna Maria Geretti, Georgios Pollakis, William A. Paxton, Linos Vandekerckhove, Alessandra Ruggiero
Publikováno v:
Life, Vol 11, Iss 12, p 1410 (2021)
Integrated HIV-1 DNA persists despite antiretroviral therapy and can fuel viral rebound following treatment interruption. Hence, methods to specifically measure the integrated HIV-1 DNA portion only are important to monitor the reservoir in eradicati
Externí odkaz:
https://doaj.org/article/c3f58432f3b94a82bcd453585c9710d9
Publikováno v:
Journal of Virus Eradication, Vol 3, Iss 4, Pp 242-249 (2017)
Externí odkaz:
https://doaj.org/article/271208ae0d9d450e8b647139fadce754